Constraints on the Physical Parameters of TeV Blazars

We consider the constraints on the physical parameters of a homogeneous SSC model that can be derived from the spectral shape and variability of TeV blazars. Assuming that the relativistic electron spectrum is a broken power law, where the break energy $\gamma_b$ is a free parameter, we write the analytical formulae that allow to connect the physical parameters of the model to observable quantities. The constraints can be summarized in a plane where the coordinates are the Doppler factor and the magnetic field. The consistency between the break energy and the balance between cooling and escape and the interpretation of the soft photon lags measured in some sources as radiative cooling times are treated as additional independent constraints. We apply themethod to the case of three well known blazars, PKS 2155-304, Mrk 421 and Mrk 501.Comment: 36 pages, incl. 6 figures in PS format, AAS LaTeX, to be published in ApJ, Dec 199

Finding and counting vertex-colored subtrees

The problems studied in this article originate from the Graph Motif problem introduced by Lacroix et al. in the context of biological networks. The problem is to decide if a vertex-colored graph has a connected subgraph whose colors equal a given multiset of colors $M$. It is a graph pattern-matching problem variant, where the structure of the occurrence of the pattern is not of interest but the only requirement is the connectedness. Using an algebraic framework recently introduced by Koutis et al., we obtain new FPT algorithms for Graph Motif and variants, with improved running times. We also obtain results on the counting versions of this problem, proving that the counting problem is FPT if M is a set, but becomes W[1]-hard if M is a multiset with two colors. Finally, we present an experimental evaluation of this approach on real datasets, showing that its performance compares favorably with existing software.Comment: Conference version in International Symposium on Mathematical Foundations of Computer Science (MFCS), Brno : Czech Republic (2010) Journal Version in Algorithmic

Exact Lattice Supersymmetry: the Two-Dimensional N=2 Wess-Zumino Model

We study the two-dimensional Wess-Zumino model with extended N=2 supersymmetry on the lattice. The lattice prescription we choose has the merit of preserving {\it exactly} a single supersymmetric invariance at finite lattice spacing $a$. Furthermore, we construct three other transformations of the lattice fields under which the variation of the lattice action vanishes to $O(ga^2)$ where $g$ is a typical interaction coupling. These four transformations correspond to the two Majorana supercharges of the continuum theory. We also derive lattice Ward identities corresponding to these exact and approximate symmetries. We use dynamical fermion simulations to check the equality of the massgaps in the boson and fermion sectors and to check the lattice Ward identities. At least for weak coupling we see no problems associated with a lack of reflection positivity in the lattice action and find good agreement with theory. At strong coupling we provide evidence that problems associated with a lack of reflection positivity are evaded for small enough lattice spacing.Comment: 29 pages, 10 figures. New results at strong coupling added. Minor corrections to text and one reference added. Version to appear in Phys. Rev.

Wess-Zumino model with exact supersymmetry on the lattice

A lattice formulation of the four dimensional Wess-Zumino model that uses Ginsparg-Wilson fermions and keeps exact supersymmetry is presented. The supersymmetry transformation that leaves invariant the action at finite lattice spacing is determined by performing an iterative procedure in the coupling constant. The closure of the algebra, generated by this transformation is also showed.Comment: 13 pages. Few references added. New appendix on Ward identity added. Version to be published in JHE

Approximating Clustering of Fingerprint Vectors with Missing Values

The problem of clustering fingerprint vectors is an interesting problem in Computational Biology that has been proposed in (Figureroa et al. 2004). In this paper we show some improvements in closing the gaps between the known lower bounds and upper bounds on the approximability of some variants of the biological problem. Namely we are able to prove that the problem is APX-hard even when each fingerprint contains only two unknown position. Moreover we have studied some variants of the orginal problem, and we give two 2-approximation algorithm for the IECMV and OECMV problems when the number of unknown entries for each vector is at most a constant.Comment: 13 pages, 4 figure

Adrenocortical Serous Cystadenoma in a Cat

9-year-old, castrated male shorthair cat was referred for an abdominal mass accidentally palpated by the owner. Ultrasound showed a large inhomogeneous cystic mass close to the left kidney. A massive ablation of the mass was performed. Four days after surgery, the cat was severely azotemic and presented signs of multiple organ dysfunction. The cat was euthanized the 7th day after surgery. Histopathological examination was consistent for adrenocortical serous cystadenoma

Passive immunoprophylaxis against respiratory syncytial virus in children: Where are we now?

Respiratory syncytial virus (RSV) represents the main cause of acute respiratory tract infections in children worldwide and is the leading cause of hospitalization in infants. RSV infection is a self-limiting condition and does not require antibiotics. However hospitalized infants with clinical bronchiolitis often receive antibiotics for fear of bacteria coinfection, especially when chest radiography is performed due to similar radiographic appearance of infiltrate and atelectasis. This may lead to unnecessary antibiotic prescription, additional cost, and increased risk of development of resistance. Despite the considerable burden of RSV bronchiolitis, to date, only symptomatic treatment is available, and there are no commercially available vaccines. The only licensed passive immunoprophylaxis is palivizumab. The high cost of this monoclonal antibody (mAb) has led to limiting its prescription only for high-risk children: infants with chronic lung disease, congenital heart disease, neuromuscular disorders, immunodeficiencies, and extreme preterm birth. Nevertheless, it has been shown that the majority of hospitalized RSV-infected children do not fully meet the criteria for immune prophylaxis. While waiting for an effective vaccine, passive immune prophylaxis in children is mandatory. There are a growing number of RSV passive immunization candidates under development intended for RSV prevention in all infants. In this review, we describe the state-of-the-art of palivizumab’s usage and summarize the clinical and preclinical trials regarding the development of mAbs with a better cost-effectiveness ratio