La telematica nella formazione a distanza: due approcci a confronto

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T3 : un progetto internazionale per la formazione degli insegnanti

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Progettare e condurre l\u27apprendimento in rete: un corso blended per futuri insegnanti

What are the main issues connected with the design and development of distance learning courses? How to plan effective courses taking into account the context requirements, the contents to be delivered, the learning needs, the resources available? This paper analyses the instructional design decisions and the delivery strategies of a blended course in Educational Technology, run by ITD-CNR for the local Postgraduate School for Secondary Teaching. The course designers developed criteria for harmonising and integrating the face-to-face and the online course components, with the aim to take advantage of their specific features. These criteria derive from a model that comprises four dimensions: the cognitive dimension, focused on the course themes and contents; the teaching dimension, focused on the teaching and learning strategies; the social dimension, focused on the interaction among participants, and the meta-cognitive dimension, focused on the reflection on the learning path and the teaching profession.Quali sono le problematiche che emergono nella progettazione e nella conduzione di iniziative di formazione in rete? Come riuscire a tener conto delle caratteristiche del contesto di formazione e della popolazione obiettivo, dei contenuti e degli obiettivi didattici per proporre interventi efficaci? In questo contributo si mettono a fuoco i principali criteri che sono stati seguiti nella progettazione e conduzione di un corso blended erogato dall\u27ITD-CNR nell\u27ambito della Scuola di Specializzazione per l\u27Insegnamento Secondario dell\u27Universit? degli Studi di Genova. Particolare attenzione ? dedicata agli aspetti che hanno contribuito a creare o rinsaldare i legami tra le attivit? svolte in presenza e quelle effettuate online. La presentazione ? organizzata intorno a quattro aspetti: a livello cognitivo, sui temi e i contenuti oggetto del corso; a livello didattico, sulle strategie di insegnamento che sono state messe in atto al fine di facilitare i processi di apprendimento; a livello sociale, sulle interazioni tra i partecipanti e sulla costituzione della comunit? di apprendimento; e, infine, a livello metacognitivo, sulla riflessione inerente il percorso di apprendimento e la professione dell\u27insegnante

Online learning: attitudes, expectations and prejudices of adult novices

The main attitudes, expectations and misconceptions of adult novices towards online learning have been investigated through a survey carried out within two different web-based courses. The data emerged from the two contexts showed several similarities: the reasons for the choice of the online approach, a positive perception of the method, a negative perception of the heavy commitment required, some resistance due to logistic and cultural difficulties. The main misconceptions include the tendency to overestimate the time flexibility offered by the collaborative approach and the inclination to underestimate the commitment required and the educational potential of written communication

Formazione a distanza e piccole e medie imprese

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Attitudes of Healthcare Workers toward Influenza Vaccination in the COVID-19 Era

none8Sani, Tommaso; Morelli, Ilaria; Sarti, Donatella; Tassinari, Giovanni; Capalbo, Maria; Espinosa, Emma; Gasperini, Beatrice; Prospero, EmiliaSani, Tommaso; Morelli, Ilaria; Sarti, Donatella; Tassinari, Giovanni; Capalbo, Maria; Espinosa, Emma; Gasperini, Beatrice; Prospero, Emili

A Prospective Study of Intraarterial Infusion Chemotherapy in Advanced WT BRAF Melanoma Patients.

ABSTRACT Background Treatment strategies for advanced cutaneous melanoma (CM) patients, resistant or not treatable with novel target and immunotherapeutic drugs, remain a significant challenge, particularly for patients with unresectable stage IIIC/D disease localized to inferior limbs and pelvis, for whom specific outcomes are rarely considered. Materials and methods This is a prospective study of multidisciplinary treatments, including locoregional melphalan chemotherapy, in 62 BRAF wild-type CM patients with locoregional metastases in the inferior limbs and pelvis, including inguinal regions. Patients were either in progression following or ineligible for, or not treatable with novel immunotherapy. For exclusively inferior limb-localised disease, patients received locoregional melphalan chemotherapy performed by hyperthermic isolated limb perfusion (n = 19) or isolated limb infusion (n = 19), and for synchronous lesions localised to inferior limbs and pelvis, received hypoxic pelvic and limb perfusion (n = 24). Additional multidisciplinary therapy included local, locoregional and systemic treatments and the primary endpoint was tumour response. Results The objective response rate following first cycle of locoregional chemotherapy was 37.1% at 3 mo and median progression-free survival was 4-mo, with 12.9% procedure-related complications, 30.6% low-grade haematological toxicity and 11.3% severe limb toxic tissue reactions. Multivariate logistic regression showed that the odds of response were significantly higher for patients ≤ 75 y of age and for patients with locoregional metastases exclusively located in the inferior limbs. Conclusion In this subgroup of CM patients with BRAF wild-type status, locoregional metastases localized to inferior limbs and pelvis, in progression following or ineligible for immunotherapy, melphalan locoregional chemotherapy demonstrated a safe and effective profile. Trial Registration ClinicalTrials.gov Identifier NCT01920516; date of trial registration: August 6, 2013

Analysis of host response to bacterial infection using error model based gene expression microarray experiments

A key step in the analysis of microarray data is the selection of genes that are differentially expressed. Ideally, such experiments should be properly replicated in order to infer both technical and biological variability, and the data should be subjected to rigorous hypothesis tests to identify the differentially expressed genes. However, in microarray experiments involving the analysis of very large numbers of biological samples, replication is not always practical. Therefore, there is a need for a method to select differentially expressed genes in a rational way from insufficiently replicated data. In this paper, we describe a simple method that uses bootstrapping to generate an error model from a replicated pilot study that can be used to identify differentially expressed genes in subsequent large-scale studies on the same platform, but in which there may be no replicated arrays. The method builds a stratified error model that includes array-to-array variability, feature-to-feature variability and the dependence of error on signal intensity. We apply this model to the characterization of the host response in a model of bacterial infection of human intestinal epithelial cells. We demonstrate the effectiveness of error model based microarray experiments and propose this as a general strategy for a microarray-based screening of large collections of biological samples

Metronomic Oral Vinorelbine: An Alternative Schedule in Elderly and Patients PS2 With Local/Advanced and Metastatic NSCLC Not Oncogene-addicted

The MILES and ELVIS studies showed that vinorelbine is one of the best options for elderly patients with advanced non-small-cell-lung cancer (NSCLC). Oral vinorelbine at standard schedule (60-80 mg/m2/weekly) has good activity in terms of response rates and progression-free survival. In recent years, a metronomic schedule of oral vinorelbine (40-50 mg/m2 three times a week, continuously) has been studied in phase II trials, especially in unfit and elderly patients. In the MOVE trial metronomic oral vinorelbine had a clinical benefit [partial response (PR)+stable disease (SD) >12 weeks] in 58.1% of patients with mild toxicity. On this basis, in 2017 we started a phase II study with metronomic oral vinorelbine in elderly (over 70 years) or unfit [Eastern Cooperative Oncology Group performance score (ECOG-PS) of 2] patients with locally/advanced and metastatic NSCLC. Primary aims were clinical benefit (PR+SD ≥6 months) and toxicity; secondary aims were progression-free survival and overall survival