SOX10 commonly stains scar in Mohs sections

Sox10 immunostaining is used for the diagnosis and margin evaluation of melanocytic lesions. Sox10 was initially thought not to stain fibrohistiocytic processes. Consequently, it was believed to reliably distinguish desmoplastic melanoma from scar. However, recent data from formalin sections suggest Sox10 is less specific than previously thought. In this report, we demonstrate that Sox10-stained Mohs sections commonly show strong, fractional staining of scar. When using Sox10 with frozen section immunohistochemistry, Mohs practitioners should recognize the potential of this marker to stain scar to avoid overdiagnosis of desmoplastic melanoma

Airport-Noise Levels and Annoyance Model (ALAMO) user's guide

A guide for the use of the Airport-Noise Level and Annoyance MOdel (ALAMO) at the Langley Research Center computer complex is provided. This document is divided into 5 primary sections, the introduction, the purpose of the model, and an in-depth description of the following subsystems: baseline, noise reduction simulation and track analysis. For each subsystem, the user is provided with a description of architecture, an explanation of subsystem use, sample results, and a case runner's check list. It is assumed that the user is familiar with the operations at the Langley Research Center (LaRC) computer complex, the Network Operating System (NOS 1.4) and CYBER Control Language. Incorporated within the ALAMO model is a census database system called SITE II

Stability and Hermitian-Einstein metrics for vector bundles on framed manifolds

We adapt the notions of stability of holomorphic vector bundles in the sense of Mumford-Takemoto and Hermitian-Einstein metrics in holomorphic vector bundles for canonically polarized framed manifolds, i.e. compact complex manifolds X together with a smooth divisor D such that K_X \otimes [D] is ample. It turns out that the degree of a torsion-free coherent sheaf on X with respect to the polarization K_X \otimes [D] coincides with the degree with respect to the complete K\"ahler-Einstein metric g_{X \setminus D} on X \setminus D. For stable holomorphic vector bundles, we prove the existence of a Hermitian-Einstein metric with respect to g_{X \setminus D} and also the uniqueness in an adapted sense.Comment: 21 pages, International Journal of Mathematics (to appear

Cost-effectiveness of counselling, graded-exercise and usual care for chronic fatigue: evidence from a randomised trial in primary care

Fatigue is common and has been shown to result in high economic costs to society. The aim of this study is to compare the cost-effectiveness of two active therapies, graded-exercise (GET) and counselling (COUN) with usual care plus a self-help booklet (BUC) for people presenting with chronic fatigue

Integrated electronic prescribing and robotic dispensing: a case study

INTRODUCTION: To quantify the benefits of electronic prescribing directly linked to a robotic dispensing machine. CASE DESCRIPTION: Quantitative case study analysis is used on a single case. Hospital A (1,000 beds) has used an integrated electronic prescribing system for 10 years, and in 2009 linked two robotic dispensing machines to the system. The impact on dispensing error rates (quality) and efficiency (costs) were assessed. EVALUATION AND DISCUSSION: The implementation delivered staff efficiencies above expectation. For the out-patient department, this was 16% more than the business case had suggested. For the in-patients dispensary, four staff were released for re-deployment. Additionally, £500,000 in stockholding efficiency above that suggested by the business case was identified. Overall dispensing error rates were not adversely affected and products dispensed by the electronic prescribing - robot system produced zero dispensing errors. The speed of dispensing increased also, as the electronic prescribing - robot combination permitted almost instantaneous dispensing from the point of a doctor entering a prescription. CONCLUSION: It was significant that the combination of electronic prescribing and a robot eliminated dispensing errors. Any errors that did occur were not as a result of the electronic prescribing - robotic system (i.e. the product was not stocked within the robot). The direct linking of electronic prescribing and robots as a dispensing system together produces efficiencies and improves the quality of the dispensing process

Assessing the Tennessee Extension Master Gardener Program Using Both County Coordinator and Extension Volunteer Perspectives

The Extension Master Gardener (EMG) program is a vital contributor to Tennessee Extension residential and consumer horticulture education and outreach. In 2014, 2,480 volunteers statewide completed service and education requirements to achieve or maintain certified EMG status. These volunteers, led by Tennessee Extension agent county coordinators, contributed over 178,800 hours of service while recording over 30,300 hours of continuing education. These totals illustrate both the contributions of EMG volunteers to horticulture outreach and their desire for education to enhance their own knowledge and skill. Understanding the most needed areas of training for EMG volunteers to support their education and outreach to residents is critical to the growth and impact of the program. Therefore, a study was undertaken in 2015 to survey both EMG volunteers and coordinators to determine educational needs for volunteers as well as the preferred training delivery methods. Respondents consistently rated horticultural training in edible and ornamental crops as well as pest and disease management as high priorities. Similarly, hands-on and in-person presentations and printed materials were rated as highly important training methods. Results indicate potential training priorities for the future but also suggest a need to explore differences between coordinator and volunteer perspectives in some areas

Emergent Calabi-Yau Geometry

We show how the smooth geometry of Calabi-Yau manifolds emerges from the thermodynamic limit of the statistical mechanical model of crystal melting defined in our previous paper arXiv:0811.2801. In particular, the thermodynamic partition function of molten crystals is shown to be equal to the classical limit of the partition function of the topological string theory by relating the Ronkin function of the characteristic polynomial of the crystal melting model to the holomorphic 3-form on the corresponding Calabi-Yau manifold.Comment: 4 pages; v2: revised discussion on wall crossing; v3: typos corrected, published versio

A cusp electron gun for millimeter wave gyrodevices

The experimental results of a thermionic cusp electron gun, to drive millimeter and submillimeter wave harmonic gyrodevices, are reported in this paper. Using a "smooth" magnetic field reversal formed by two coils this gun generated an annular-shaped, axis-encircling electron beam with 1.5 A current, and an adjustable velocity ratio alpha of up to 1.56 at a beam voltage of 40 kV. The beam cross-sectional shape and transported beam current were measured by a witness plate technique and Faraday cup, respectively. These measured results were found to be in excellent agreement with the simulated results using the three-dimensional code MAGIC

N=2 Topological Yang-Mills Theory on Compact K\"{a}hler Surfaces

We study a topological Yang-Mills theory with $N=2$ fermionic symmetry. Our formalism is a field theoretical interpretation of the Donaldson polynomial invariants on compact K\"{a}hler surfaces. We also study an analogous theory on compact oriented Riemann surfaces and briefly discuss a possible application of the Witten's non-Abelian localization formula to the problems in the case of compact K\"{a}hler surfaces.Comment: ESENAT-93-01 & YUMS-93-10, 34pages: [Final Version] to appear in Comm. Math. Phy

The effect of prolonged simulated non- gravitational environment on mineral balance in the adult male, volume 1 Final report

Effect of prolonged bed rest with simulated weightlessness on mineral balance in male adult - Vol.