Chi-Square Test is Statistically Significant: Now What?

Applied researchers have employed chi-square tests for more than one hundred years. This paper addresses the question of how one should follow a statistically significant chi-square test result in order to determine the source of that result. Four approaches were evaluated: calculating residuals, comparing cells, ransacking, and partitioning. Data from two recent journal articles were used to illustrate these approaches. A call is made for greater consideration of foundational techniques such as the chi-square tests. Accessed 74,155 times on https://pareonline.net from April 06, 2015 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right

Scenario Testing of the Energy and Environmental Performance of “The Glasgow House”

This paper describes the results from a 12-month study of two prototype low energy dwellings built for Glasgow Housing Association (GHA). The houses are intended for mainstream and social tenure within Glasgow and contain a range of energy reducing features including one house with a thermally heavy clay block wall and one house using a conventional timber frame and both houses have sunspaces, Mechanical Ventilation with Heat Recovery (MVHR), solar thermal system and low energy lighting. The dwellings have been subject to an innovative monitoring strategy by MEARU, whereby test occupants (students recruited from the School of Architecture) have been asked to inhabit the buildings for six two-week periods using occupancy ‘scripts’ that determine their internal behaviour. The scenarios thus simulate varying patterns of occupancy in both houses simultaneously and the performance of the houses can then been compared. Indications are that although the clay block house had a poorer thermal performance, it did have other qualitative advantages, and consumption differences could be eliminated by exploiting the thermal mass. The performance of the active systems, including the MVHR system, was found to be problematic, and specific scenarios were undertaken to explore the implications of this

Glasgow House Performance Evaluation Report

This report has been produced by the Mackintosh Environmental Architecture Research Unit (MEARU) on behalf of Glasgow Housing Association (GHA) and, in broadest terms, analyses the simulated and in use performance of two prototype houses constructed for GHA by City Building (Glasgow) LLP at, Norfolk Street, Glasgow

The trajectory of maternal and paternal fatigue and factors associated with fatigue across the transition to parenthood

BackgroundFatigue is prevalent in new parents and is associated with poorer functional performance and cognitive functioning. This can be particularly detrimental during the transition to parenthood when parents are adapting to new roles and demands. Examining the course of fatigue and related factors can provide important avenues for intervention and prevention.MethodsIn this longitudinal study, we assessed fatigue and its correlates in 108 mother/father couples. Multilevel modelling examined the prevalence and trajectory of fatigue across the transition to parenthood, as well as factors associated with post‐partum fatigue. Parents completed measures of fatigue, prenatal stress, depression and health, and post‐natal parental sleep quality, infant sleep duration, and infant negativity.ResultsMothers' and fathers' fatigue increased following the birth of their infant and remained at high levels. Poor sleep quality, stress, and depression were associated with maternal and paternal fatigue, while infant characteristics were more strongly associated with maternal fatigue. Prenatal depressive symptoms, parental sleep quality, infant sleep duration, and the interaction of gender by prenatal fatigue predicted post‐natal fatigue in our model.ConclusionOur results highlight the need for health professionals to educate new parents about fatigue and its management beyond the prenatal period. As correlates of fatigue for mothers and fathers differ, we need to expand our understanding of paternal fatigue and develop interventions tailored to their unique experiences.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110817/1/cp12048.pd

Indoor Annual Sunlight Opportunity in Domestic Dwellings May Predict Well-Being in Urban Residents in Scotland

Indoor sunlight improves health in hospitals, schools, and workplaces, and there is clinical evidence for the impact on depression. But the impact of indoor sunlight on residents' health and well-being in domestic dwellings is unclear. Understanding this relationship could have important implications for building design and residents' indoor behavior, and impacts on health. Using a cross-sectional survey, we investigated the relationship between annual indoor sunlight opportunity and psychological well-being in 40 residents of high-rise dwellings in a socioeconomically deprived area in Glasgow, Scotland.  Perceived physical health, physical activity, psychological distress, and indoor environmental factors were potential mediators of the relationship between annual sunlight opportunity and well-being. We used novel simulation modeling of window size, orientation, occlusion, and occupant behavior to measure annual sunlight opportunity.  We found a significant positive association between well-being and annual indoor sunlight opportunity but no relationship between sunlight and objective indoor environmental variables, including air quality, bacteria, and fungi. Our sample had generally poor physical and mental health. Perceived physical health, lower psychological distress, more physical activity, and better perceived environmental quality were associated with greater psychological well-being. Perceived physical health mediated the impact of sunlight on well-being. Findings merit replication in larger and more diverse samples but have important implications for building design and advice to residents on window occlusion.&nbsp

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles

Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial. This study sought to investigate whether a heterologous prime-boost-boost vaccine regimen in Chinese cynomolgus macaques with a DNA vaccine and recombinant poxviral vectors expressing HIV virus-like particles bearing envelopes derived from the most prevalent clades circulating in sub-Saharan Africa, focused the antibody response to shared neutralising epitopes. Methods: Three Chinese cynomolgus macaques were immunised via intramuscular injections using a regimen composed of a prime with two DNA vaccines expressing clade A Env/clade B Gag followed by boosting with recombinant fowlpox virus expressing HIV-1 clade D Gag, Env and cholera toxin B subunit followed by the final boost with recombinant modified vaccinia virus Ankara expressing HIV-1 clade C Env, Gag and human complement protein C3d. We measured the macaque serum antibody responses by ELISA, enumerated T cell responses by IFN-gamma ELISpot and assessed seroneutralisation of HIV-1 using the TZM-bl beta-galactosidase assay with primary isolates of HIV-1. Results: This study shows that large and complex synthetic DNA sequences can be successfully cloned in a single step into two poxvirus vectors: MVA and FPV and the recombinant poxviruses could be grown to high titres. The vaccine candidates showed appropriate expression of recombinant proteins with the formation of authentic HIV virus-like particles seen on transmission electron microscopy. In addition the b12 epitope was shown to be held in common by the vaccine candidates using confocal immunofluorescent microscopy. The vaccine candidates were safely administered to Chinese cynomolgus macaques which elicited modest T cell responses at the end of the study but only one out of the three macaques elicited an HIV-specific antibody response. However, the antibodies did not neutralise primary isolates of HIV-1 or the V3-sensitive isolate SF162 using the TZM-bl b-galactosidase assay. Conclusions: MVA and FP9 are ideal replication-deficient viral vectors for HIV-1 vaccines due to their excellent safety profile for use in humans. This study shows this novel prime-boost-boost regimen was poorly immunogenic in Chinese cynomolgus macaques