311 research outputs found
Parenting while living with advanced cancer: A qualitative study
Patients with advanced cancer who have dependent children are an important population with a life-limiting illness and high levels of psychological distress. Few studies have addressed the experience of being a parent with advanced cancer and their potential palliative needs
Faint High Latitude Carbon Stars Discovered by the Sloan Digital Sky Survey: Methods and Initial Results
We report the discovery of 39 Faint High Latitude Carbon Stars (FHLCs) from
Sloan Digital Sky Survey commissioning data. The objects, each selected
photometrically and verified spectroscopically, range over 16.6 < r* < 20.0,
and show a diversity of temperatures as judged by both colors and NaD line
strengths. At the completion of the Sloan Survey, there will be many hundred
homogeneously selected and observed FHLCs in this sample. We present proper
motion measures for each object, indicating that the sample is a mixture of
extremely distant (>100 kpc) halo giant stars, useful for constraining halo
dynamics, plus members of the recently-recognized exotic class of very nearby
dwarf carbon (dC) stars. Motions, and thus dC classification, are inferred for
40-50 percent of the sample, depending on the level of statistical significance
invoked. The new list of dC stars presented here, although selected from only a
small fraction of the final SDSS, doubles the number of such objects found by
all previous methods. (Abstract abridged).Comment: Accepted for publication in The Astronomical Journal, Vol. 124, Sep.
2002, 40 pages, 7 figures, AASTeX v5.
Equivalence of ELISpot Assays Demonstrated between Major HIV Network Laboratories
The Comprehensive T Cell Vaccine Immune Monitoring Consortium (CTC-VIMC) was created to provide standardized immunogenicity monitoring services for HIV vaccine trials. The ex vivo interferon-gamma (IFN-γ) ELISpot is used extensively as a primary immunogenicity assay to assess T cell-based vaccine candidates in trials for infectious diseases and cancer. Two independent, GCLP-accredited central laboratories of CTC-VIMC routinely use their own standard operating procedures (SOPs) for ELISpot within two major networks of HIV vaccine trials. Studies are imperatively needed to assess the comparability of ELISpot measurements across laboratories to benefit optimal advancement of vaccine candidates.We describe an equivalence study of the two independently qualified IFN-g ELISpot SOPs. The study design, data collection and subsequent analysis were managed by independent statisticians to avoid subjectivity. The equivalence of both response rates and positivity calls to a given stimulus was assessed based on pre-specified acceptance criteria derived from a separate pilot study.Detection of positive responses was found to be equivalent between both laboratories. The 95% C.I. on the difference in response rates, for CMV (-1.5%, 1.5%) and CEF (-0.4%, 7.8%) responses, were both contained in the pre-specified equivalence margin of interval [-15%, 15%]. The lower bound of the 95% C.I. on the proportion of concordant positivity calls for CMV (97.2%) and CEF (89.5%) were both greater than the pre-specified margin of 70%. A third CTC-VIMC central laboratory already using one of the two SOPs also showed comparability when tested in a smaller sub-study.The described study procedure provides a prototypical example for the comparison of bioanalytical methods in HIV vaccine and other disease fields. This study also provides valuable and unprecedented information for future vaccine candidate evaluations on the comparison and pooling of ELISpot results generated by the CTC-VIMC central core laboratories
Sloan Digital Sky Survey Imaging of Low Galactic Latitude Fields: Technical Summary and Data Release
The Sloan Digital Sky Survey (SDSS) mosaic camera and telescope have obtained
five-band optical-wavelength imaging near the Galactic plane outside of the
nominal survey boundaries. These additional data were obtained during
commissioning and subsequent testing of the SDSS observing system, and they
provide unique wide-area imaging data in regions of high obscuration and star
formation, including numerous young stellar objects, Herbig-Haro objects and
young star clusters. Because these data are outside the Survey regions in the
Galactic caps, they are not part of the standard SDSS data releases. This paper
presents imaging data for 832 square degrees of sky (including repeats), in the
star-forming regions of Orion, Taurus, and Cygnus. About 470 square degrees are
now released to the public, with the remainder to follow at the time of SDSS
Data Release 4. The public data in Orion include the star-forming region NGC
2068/NGC 2071/HH24 and a large part of Barnard's loop.Comment: 31 pages, 9 figures (3 missing to save space), accepted by AJ, in
press, see http://photo.astro.princeton.edu/oriondatarelease for data and
paper with all figure
New insights on the Draco dwarf spheroidal galaxy from SDSS: a larger radius and no tidal tails
We have investigated the spatial extent and structure of the Draco dwarf
spheroidal galaxy using deep wide-field multicolor CCD photometry from the
Sloan Digital Sky Survey (SDSS). Our study covers an area of 27 square degrees
around the center of the Draco dwarf. We show that the spatial distribution of
Draco's red giants, red horizontal branch stars and subgiants down to i=21.7
mag does not provide evidence for the existence of tidally induced tails or a
halo of unbound stars. The radial profile can be fit by King models as well as
by a generalized exponential. The core radius and the limiting (or tidal)
radius along the major axis are 7.7' and 40.1', respectively, making Draco 40%
larger than previously measured. Down to our magnitude limit tidal effects can
only exist at a level of 10^-3 of the central surface density of Draco or
below. The regular structure of Draco found from the new data argues against it
being a portion of an unbound tidal stream and lends support to the assumption
of dynamical equilibrium. We estimate Draco's total mass to be 2.2 - 3.5 times
10^7 solar masses. We obtain an overall mass-to-light ratio of 146+-42 or
92+-28 solar masses depending on the details of the mass and luminosity
estimates. In summary, our results strengthen the case for a strongly dark
matter dominated, bound stellar system. (Abstract strongly abridged).Comment: 30 pages, 11 figures (in part with degraded resolution). Accepted for
publication in the Astronomical Journa
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A genome-wide association study of malting quality across eight US barley breeding programs
We report malt quality QTLs relevant to breeding with greater precision than previous mapping studies. The distribution of favorable alleles suggests strategies for marker-assisted breeding and germplasm exchange.
This study leverages the breeding data of 1,862 barley breeding lines evaluated in 97 field trials for genome-wide association study of malting quality traits in barley. The mapping panel consisted of six-row and two-row advanced breeding lines from eight breeding populations established at six public breeding programs across the United States. A total of 4,976 grain samples were subjected to micro-malting analysis and mapping of nine quality traits was conducted with 3,072 SNP markers distributed throughout the genome. Association mapping was performed for individual breeding populations and for combined six-row and two-row populations. Only 16 % of the QTL we report here had been detected in prior bi-parental mapping studies. Comparison of the analyses of the combined two-row and six-row panels identified only two QTL regions that were common to both. In total, 108 and 107 significant marker-trait associations were identified in all six-row and all two-row breeding programs, respectively. A total of 102 and 65 marker-trait associations were specific to individual six-row and two-row breeding programs, respectively indicating that most marker-trait associations were breeding population specific. Combining datasets from different breeding program resulted in both the loss of some QTL that were apparent in the analyses of individual programs and the discovery of new QTL not identified in individual programs. This suggests that simply increasing sample size by pooling samples with different breeding history does not necessarily increase the power to detect associations. The genetic architecture of malting quality and the distribution of favorable alleles suggest strategies for marker-assisted selection and germplasm exchangeThis is the publisher’s final pdf. The published article is copyrighted by Springer and can be found at: http://link.springer.com/journal/122. Supporting information located at: http://link.springer.com/article/10.1007%2Fs00122-015-2465-
The Fifth Data Release of the Sloan Digital Sky Survey
This paper describes the Fifth Data Release (DR5) of the Sloan Digital Sky
Survey (SDSS). DR5 includes all survey quality data taken through June 2005 and
represents the completion of the SDSS-I project (whose successor, SDSS-II will
continue through mid-2008). It includes five-band photometric data for 217
million objects selected over 8000 square degrees, and 1,048,960 spectra of
galaxies, quasars, and stars selected from 5713 square degrees of that imaging
data. These numbers represent a roughly 20% increment over those of the Fourth
Data Release; all the data from previous data releases are included in the
present release. In addition to "standard" SDSS observations, DR5 includes
repeat scans of the southern equatorial stripe, imaging scans across M31 and
the core of the Perseus cluster of galaxies, and the first spectroscopic data
from SEGUE, a survey to explore the kinematics and chemical evolution of the
Galaxy. The catalog database incorporates several new features, including
photometric redshifts of galaxies, tables of matched objects in overlap regions
of the imaging survey, and tools that allow precise computations of survey
geometry for statistical investigations.Comment: ApJ Supp, in press, October 2007. This paper describes DR5. The SDSS
Sixth Data Release (DR6) is now public, available from http://www.sdss.or
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