80 research outputs found
Contamination of spacecraft by recontact of dumped liquids
Liquids partially freeze when dumped from spacecraft producing particles which are released into free space at various velocities. Recontact of these particles with the spacecraft is possible for specific particle sizes and velocities and, therefore, can become contamination for experiments within the spacecraft or released experiments as a result of waste and potable water dumped from Space Shuttle. An examination of dump characteristics was conducted on STS-29 using both on-board video records and ground based measurements. A preliminary analysis of data from this flight indicates particle velocities are in the range of 30 to 75 ft/sec and recontact is possible for limited particle sizes
Why do UK banks securitize?
Working paper seriesThe eight years from 2000 to 2008 saw a rapid growth in the use of securitization by UK
banks. We aim to identify the reasons that contributed to this rapid growth. The time period
(2000 to 2010) covered by our study is noteworthy as it covers the pre- nancial crisis credit-
boom, the peak of the nancial crisis and its aftermath. In the wake of the nancial crisis,
many governments, regulators and political commentators have pointed an accusing nger at
the securitization market - even in the absence of a detailed statistical and economic analysis.
We contribute to the extant literature by performing such an analysis on UK banks, fo-
cussing principally on whether it is the need for liquidity (i.e. the funding of their balance
sheets), or the desire to engage in regulatory capital arbitrage or the need for credit risk trans-
fer that has led to UK banks securitizing their assets.
We show that securitization has been signi cantly driven by liquidity reasons. In addition,
we observe a positive link between securitization and banks credit risk. We interpret these
latter ndings as evidence that UK banks which engaged in securitization did so, in part, to
transfer credit risk and that, in comparison to UK banks which did not use securitization, they
had more credit risk to transfer in the sense that they originated lower quality loans and held
lower quality assets. We show that banks which issued more asset-backed securities before the
nancial crisis su¤ered more defaults after the nancial crisis.The eight years from 2000 to 2008 saw a rapid growth in the use of securitization by UK
banks. We aim to identify the reasons that contributed to this rapid growth. The time period
(2000 to 2010) covered by our study is noteworthy as it covers the pre-financial crisis credit-
boom, the peak of the financial crisis and its aftermath. In the wake of the financial crisis,
many governments, regulators and political commentators have pointed an accusing finger at
the securitization market - even in the absence of a detailed statistical and economic analysis.
We contribute to the extant literature by performing such an analysis on UK banks, fo-
cussing principally on whether it is the need for liquidity (i.e. the funding of their balance
sheets), or the desire to engage in regulatory capital arbitrage or the need for credit risk trans-
fer that has led to UK banks securitizing their assets.
We show that securitization has been significantly driven by liquidity reasons. In addition,
we observe a positive link between securitization and banks credit risk. We interpret these
latter findings as evidence that UK banks which engaged in securitization did so, in part, to
transfer credit risk and that, in comparison to UK banks which did not use securitization, they
had more credit risk to transfer in the sense that they originated lower quality loans and held
lower quality assets. We show that banks which issued more asset-backed securities before the
financial crisis suffered more defaults after the financial crisis
Identifying Human Disease Genes through Cross-Species Gene Mapping of Evolutionary Conserved Processes
Understanding complex networks that modulate development in humans is hampered by genetic and phenotypic heterogeneity within and between populations. Here we present a method that exploits natural variation in highly diverse mouse genetic reference panels in which genetic and environmental factors can be tightly controlled. The aim of our study is to test a cross-species genetic mapping strategy, which compares data of gene mapping in human patients with functional data obtained by QTL mapping in recombinant inbred mouse strains in order to prioritize human disease candidate genes.We exploit evolutionary conservation of developmental phenotypes to discover gene variants that influence brain development in humans. We studied corpus callosum volume in a recombinant inbred mouse panel (C57BL/6JĂDBA/2J, BXD strains) using high-field strength MRI technology. We aligned mouse mapping results for this neuro-anatomical phenotype with genetic data from patients with abnormal corpus callosum (ACC) development.).This approach that exploits highly diverse mouse strains provides an efficient and effective translational bridge to study the etiology of human developmental disorders, such as autism and schizophrenia
A Mammalian Conserved Element Derived from SINE Displays Enhancer Properties Recapitulating Satb2 Expression in Early-Born Callosal Projection Neurons
Short interspersed repetitive elements (SINEs) are highly repeated sequences that account for a significant proportion of many eukaryotic genomes and are usually considered âjunk DNAâ. However, we previously discovered that many AmnSINE1 loci are evolutionarily conserved across mammalian genomes, suggesting that they may have acquired significant functions involved in controlling mammalian-specific traits. Notably, we identified the AS021 SINE locus, located 390 kbp upstream of Satb2. Using transgenic mice, we showed that this SINE displays specific enhancer activity in the developing cerebral cortex. The transcription factor Satb2 is expressed by cortical neurons extending axons through the corpus callosum and is a determinant of callosal versus subcortical projection. Mouse mutants reveal a crucial function for Sabt2 in corpus callosum formation. In this study, we compared the enhancer activity of the AS021 locus with Satb2 expression during telencephalic development in the mouse. First, we showed that the AS021 enhancer is specifically activated in early-born Satb2+ neurons. Second, we demonstrated that the activity of the AS021 enhancer recapitulates the expression of Satb2 at later embryonic and postnatal stages in deep-layer but not superficial-layer neurons, suggesting the possibility that the expression of Satb2 in these two subpopulations of cortical neurons is under genetically distinct transcriptional control. Third, we showed that the AS021 enhancer is activated in neurons projecting through the corpus callosum, as described for Satb2+ neurons. Notably, AS021 drives specific expression in axons crossing through the ventral (TAG1â/NPY+) portion of the corpus callosum, confirming that it is active in a subpopulation of callosal neurons. These data suggest that exaptation of the AS021 SINE locus might be involved in enhancement of Satb2 expression, leading to the establishment of interhemispheric communication via the corpus callosum, a eutherian-specific brain structure
Conservation, Environmental & Safety Education
Photograph of Lincoln Elementary third grade students on a bus on a conservation tour. OK-4285-5
Learning `otherWISE': being wise about consumption
Young people living in the ten richest countries in the world spend more than 700 billion US (UNESCO-UNEP 2002)
A CHECKLIST OF THE MACRO INVERTEBRATES OF THE PROVO RIVER UTAH
Volume: 32Start Page: 211End Page: 21
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