8 research outputs found
Supplementary Figure 3: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary figure</p
Supplementary bronchoalveolar lavage protocol: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary protocol</p
Supplementary Figure 4: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary figures</p
Supplementary Figure 2: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary figure</p
Supplementary Figure 1: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary figure</p
Supplementary Figure 6: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary figures</p
Supplementary Figure 5: Single-cell RNA sequencing of bronchoscopy specimens: development of a rapid minimal handling protocol
Supplementary figures</p
Genetic Associations and Architecture of Asthma-COPD Overlap
Background
Some people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone.
Research Question
What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD overlap differ from those for COPD or asthma?
Study Design and Methods
We conducted a genome-wide association study in 8,068 asthma-COPD overlap case subjects and 40,360 control subjects without asthma or COPD of European ancestry in UK Biobank (stage 1). We followed up promising signals (P
Results
We selected 31 independent variants for further investigation in stage 2, and discovered eight novel signals (P
Interpretation
We identified eight signals for asthma-COPD overlap, which may represent loci that predispose to type 2 inflammation, and serious long-term consequences of asthma.</p