Atomic resolution insight into host cell recognition by Toxoplasma gondii.

Accepted versio

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Le discours communiste

THE COMMUNIST DISCOURSE, by DOMINIQUE LABBE A lexical analysis of the resolutions of the last fair conferences of the French Communist Party (PCF) (1972-1979) describes the unvarying forms which are the characteristic of the communist discourse (for example, the PCF's identification with the working class and with socialism). The analysis also reveals substantial discursive changes in a dogmatic and sectarian direction, but the hypothesis of a " return to the past " cannot be confirmed for all that. Lastly, the findings show that it was at the end of 1974 that the PCF broke with the strategy of the union of the Left based on the joint programme. [Revue française de science politique XXX (1), février 1980, pp. 46-77.]LE DISCOURS COMMUNISTE, par DOMINIQUE LABBÉ Une analyse lexicale appliquée aux résolutions des quatre derniers congrès du PCF (1972-1979) décrit les figures invariantes qui sont la caractéristique du discours communiste (par exemple l'identification du PCF à la classe ouvrière et au socialisme). L'analyse fait également apparaître d'importantes modifications discursives dans un sens dogmatique et sectaire mais l'hypothèse d'un « retour en arrière » ne se vérifie pas pour autant. Enfin, les résultats permettent de situer à la fin de 1974 la rupture du PCF avec la stratégie d'union de la gauche autour du programme commun. [Revue française de science politique XXX (1), février 1980, pp. 46-77.]Labbe Dominique. Le discours communiste. In: Revue française de science politique, 30ᵉ année, n°1, 1980. pp. 46-77

La crise des syndicats français

Labbe Dominique. La crise des syndicats français. In: Revue française de science politique, 42ᵉ année, n°4, 1992. pp. 646-653

Les élections des comités d'entreprise

Labbe Dominique. Les élections des comités d'entreprise. In: Revue française de science politique, 43ᵉ année, n°2, 1993. pp. 317-326

Les élections des comités d'entreprise

Labbe Dominique. Les élections des comités d'entreprise. In: Revue française de science politique, 43ᵉ année, n°2, 1993. pp. 317-326

La crise des syndicats français

Labbe Dominique. La crise des syndicats français. In: Revue française de science politique, 42ᵉ année, n°4, 1992. pp. 646-653

Moi et l'autre. Le débat Giscard d'Estaing-Mitterrand

Comparing what Mr. Giscard d'Estaing and Mr. Mitterrand said during their debate on 5 May 1981 reveals very different types of " enunciation ". This analysis concerns the pronouns, actantial structure, time and "modalisation" of their speech. It brings out the two opponents' presuppositions and clarifies their respective strategies of persuasion.Labbe Dominique. Moi et l'autre. Le débat Giscard d'Estaing-Mitterrand. In: Revue française de science politique, 31ᵉ année, n°5-6, 1981. pp. 951-981