Tilted String Cosmologies

Global symmetries of the string effective action are employed to generate tilted, homogeneous Bianchi type VI_h string cosmologies from a previously known stiff perfect fluid solution to Einstein gravity. The dilaton field is not constant on the surfaces of homogeneity. The future asymptotic state of the models is interpreted as a plane wave and is itself an exact solution to the string equations of motion to all orders in the inverse string tension. An inhomogeneous generalization of the Bianchi type III model is also found.Comment: 9 pages, Standard Latex Source. To appear in Physics Letters B Minor change: Authors now alphabetically liste

Primordial black holes in braneworld cosmologies: Formation, cosmological evolution and evaporation

We consider the population evolution and evaporation of primordial black holes in the simplest braneworld cosmology, Randall-Sundrum type II. We demonstrate that black holes forming during the high-energy phase of this theory (where the expansion rate is proportional to the density) have a modified evaporation law, resulting in a longer lifetime and lower temperature at evaporation, while those forming in the standard regime behave essentially as in the standard cosmology. For sufficiently large values of the AdS radius, the high-energy regime can be the one relevant for primordial black holes evaporating at key epochs such as nucleosynthesis and the present. We examine the formation epochs of such black holes, and delimit the parameter regimes where the standard scenario is significantly modified.Comment: 9 pages RevTeX4 file with four figures incorporated, minor changes to match published versio

Primordial black holes in braneworld cosmologies: astrophysical constraints

In two recent papers we explored the modifications to primordial black hole physics when one moves to the simplest braneworld model, Randall--Sundrum type II. Both the evaporation law and the cosmological evolution of the population can be modified, and additionally accretion of energy from the background can be dominant over evaporation at high energies. In this paper we present a detailed study of how this impacts upon various astrophysical constraints, analyzing constraints from the present density, from the present high-energy photon background radiation, from distortion of the microwave background spectrum, and from processes affecting light element abundances both during and after nucleosynthesis. Typically, the constraints on the formation rate of primordial black holes weaken as compared to the standard cosmology if black hole accretion is unimportant at high energies, but can be strengthened in the case of efficient accretion.Comment: 17 pages RevTeX4 file with three figures incorporated; final paper in series astro-ph/0205149 and astro-ph/0208299. Minor changes to match version accepted by Physical Review

Primordial black holes in braneworld cosmologies: Accretion after formation

We recently studied the formation and evaporation of primordial black holes in a simple braneworld cosmology, namely Randall-Sundrum Type II. Here we study the effect of accretion from the cosmological background onto the black holes after formation. While it is generally believed that in the standard cosmology such accretion is of negligible importance, we find that during the high-energy regime of braneworld cosmology accretion can be the dominant effect and lead to a mass increase of potentially orders of magnitude. However, unfortunately the growth is exponentially sensitive to the accretion efficiency, which cannot be determined accurately. Since accretion becomes unimportant once the high-energy regime is over, it does not affect any constraints expressed at the time of black hole evaporation, but it can change the interpretation of those constraints in terms of early Universe formation rates.Comment: 6 pages RevTeX4 file. Extension to discussion of thermal balance and grey-body factor

Effects of anisotropy and spatial curvature on the pre-big bang scenario

A class of exact, anisotropic cosmological solutions to the vacuum Brans-Dicke theory of gravity is considered within the context of the pre-big bang scenario. Included in this class are the Bianchi type III, V and VI_h models and the spatially isotropic, negatively curved Friedmann-Robertson-Walker universe. The effects of large anisotropy and spatial curvature are determined. In contrast to negatively curved Friedmann-Robertson-Walker model, there exist regions of the parameter space in which the combined effects of curvature and anisotropy prevent the occurrence of inflation. When inflation is possible, the necessary and sufficient conditions for successful pre-big bang inflation are more stringent than in the isotropic models. The initial state for these models is established and corresponds in general to a gravitational plane wave.Comment: 15 pages, including 2 eps figure

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Background: Cerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, damage extends into normal-appearing brain and microvascular dysfunctions include abnormal blood–brain barrier leakage, vasoreactivity and pulsatility, but much remains unknown regarding underlying pathophysiology, symptoms, clinical features and risk factors of small vessel disease. Patients and Methods: The Mild Stroke Study 3 is a prospective observational cohort study to identify risk factors for and clinical implications of small vessel disease progression and regression among up to 300 adults with non-disabling stroke. We perform detailed serial clinical, cognitive, lifestyle, physiological, retinal and brain magnetic resonance imaging assessments over one year; we assess cerebrovascular reactivity, blood flow, pulsatility and blood–brain barrier leakage on magnetic resonance imaging at baseline; we follow up to four years by post and phone. The study is registered ISRCTN 12113543. Summary: Factors which influence direction and rate of change of small vessel disease lesions are poorly understood. We investigate the role of small vessel dysfunction using advanced serial neuroimaging in a deeply phenotyped cohort to increase understanding of the natural history of small vessel disease, identify those at highest risk of early disease progression or regression and uncover novel targets for small vessel disease prevention and therapy