Corrections to the SU(3)×SU(3){\bf SU(3)\times SU(3)} Gell-Mann-Oakes-Renner relation and chiral couplings L8rL^r_8 and H2rH^r_2

Next to leading order corrections to the $SU(3) \times SU(3)$ Gell-Mann-Oakes-Renner relation (GMOR) are obtained using weighted QCD Finite Energy Sum Rules (FESR) involving the pseudoscalar current correlator. Two types of integration kernels in the FESR are used to suppress the contribution of the kaon radial excitations to the hadronic spectral function, one with local and the other with global constraints. The result for the pseudoscalar current correlator at zero momentum is $\psi_5(0) = (2.8 \pm 0.3) \times 10^{-3} GeV^{4}$, leading to the chiral corrections to GMOR: $\delta_K = (55 \pm 5)$. The resulting uncertainties are mostly due to variations in the upper limit of integration in the FESR, within the stability regions, and to a much lesser extent due to the uncertainties in the strong coupling and the strange quark mass. Higher order quark mass corrections, vacuum condensates, and the hadronic resonance sector play a negligible role in this determination. These results confirm an independent determination from chiral perturbation theory giving also very large corrections, i.e. roughly an order of magnitude larger than the corresponding corrections in chiral $SU(2) \times SU(2)$. Combining these results with our previous determination of the corrections to GMOR in chiral $SU(2) \times SU(2)$, $\delta_\pi$, we are able to determine two low energy constants of chiral perturbation theory, i.e. $L^r_8 = (1.0 \pm 0.3) \times 10^{-3}$, and $H^r_2 = - (4.7 \pm 0.6) \times 10^{-3}$, both at the scale of the $\rho$-meson mass.Comment: Revised version with minor correction

The origin of the Acheulean: the 1.7 million-year-old site of FLK West, Olduvai Gorge (Tanzania)

The appearance of the Acheulean is one of the hallmarks of human evolution. It represents the emergence of a complex behavior, expressed in the recurrent manufacture of large-sized tools, with standardized forms, implying more advance forethought and planning by hominins than those required by the precedent Oldowan technology. The earliest known evidence of this technology dates back to c. 1.7 Ma. and is limited to two sites (Kokiselei [Kenya] and Konso [Ethiopia]), both of which lack fauna. The functionality of these earliest Acheulean assemblages remains unknown. Here we present the discovery of another early Acheulean site also dating to c. 1.7 Ma from Olduvai Gorge. This site provides evidence of the earliest steps in developing the Acheulean technology and is the oldest Acheulean site in which stone tools occur spatially and functionally associated with the exploitation of fauna. Simple and elaborate large-cutting tools (LCT) and handaxes co-exist at FLK West, showing that complex cognition was present from the earliest stages of the Acheulean. Here we provide a detailed technological study and evidence of the use of these tools on the butchery and consumption of fauna, probably by early Homo erectus sensu lato

Increased adiposity appraised with cun-bae is highly predictive of incident hypertension. The sun project

Overweight and obesity are growing worldwide and strongly associated with hypertension. The Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) index is proposed as an optimal indicator of body fatness. We aimed to investigate the association of body fat as captured by the CUN-BAE index with incident hypertension in a Mediterranean population. We assessed 15,950 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (63.7% women) initially free of hypertension. Participants completed follow-up questionnaires biennially. A validated 136-item food-frequency questionnaire was administered at baseline. We used Cox models adjusted for multiple confounders. Among 12.3 years of median follow-up (interquartile range: 8.3, 15.0 years), 2160 participants reported having received a diagnosis of hypertension. We observed a strong direct association between progressively higher the CUN-BAE index at baseline and incident hypertension during follow-up in multivariable-adjusted models for men and women, even after further adjustment for BMI ≥ 30 kg/m2, showing a significant association also in non-obese participants. For each 2-unit increase in the CUN-BAE index, hypertension risk increased by 27% and 29% in men and women, respectively. The results remained significant when considering longitudinal repeated measures of changes in body fat assessed with the CUN-BAE index among the different biennial follow-up questionnaires. Our results emphasize the importance of reducing and maintaining a low body fat to prevent hypertension

Production, Processing, Commercialization and Analysis of Costumer Preferences of Sheep Cheese in Chile

The constant increase in the demand for dairy products and their derivatives has generated a higher consumption of dairy products (113.5 t/year). Chile has not been the exception; in 2017, it presented an average per capita consumption of 11.1 kg of cheese, making it the largest consumer in Latin America, followed by Argentina (7.5 kg) and Uruguay (5 kg). Although Chile does not have a strong tradition of consuming sheep’s milk cheese compared with other (European) countries, in recent years, there have been changes in the demands and expectations of cheese consumers, who demand higher quality and a wider range of varieties, thus establishing the potential for further products to enter the market. The global cheese industry has taken charge of these trends through the phenomenon of granting a premium value to certain products, adding new ingredients and flavors, producing limited editions of certain products, favoring traditional recipes and craft methods, and highlighting specific localities of origin. Given a greater appreciation for and popularity of locally produced cheeses and value-added products, particularly those with the highly valued “Designation of Origin” label, this would offer a potential for expansion in the Chilean market

A deeper look at the dust attenuation law of star-forming galaxies at high redshift

A diverse range of dust attenuation laws is found in star-forming galaxies. In particular, Tress et al. (2018) studied the SHARDS survey to constrain the NUV bump strength (B) and the total-to-selective ratio (R-V) of 1753 star-forming galaxies in the GOODS-N field at 1.5 < z < 3. We revisit here this sample to assess the implications and possible causes of the correlation found between R-V and B. The UVJ bicolour plot and main sequence of star formation are scrutinized to look for clues into the observed trend. The standard boundary between quiescent and star-forming galaxies is preserved when taking into account the wide range of attenuation parameters. However, an additional degeneracy - regarding the effective attenuation law - is added to the standard loci of star-forming galaxies in the UVJ diagram. A simple phenomenological model with an age-dependent extinction (at fixed dust composition) is compatible with the observed trend between R-V and B, whereby the opacity decreases with the age of the populations, resulting in a weaker NUV bump when the overall attenuation is shallower (greyer). In addition, we compare the constraints obtained by the SHARDS sample with dust models from the literature, supporting a scenario where geometry could potentially drive the correlation between R-V and B

Milky Way Demographics with the VVV Survey II. Color Transformations and Near-Infrared Photometry for 136 Million Stars in the Southern Galactic Disk

The new multi-epoch near-infrared VVV survey (VISTA Variables in the Via Lactea) is sampling 562 sq. deg of the Galactic bulge and adjacent regions of the disk. Accurate astrometry established for the region surveyed allows the VVV data to be merged with overlapping surveys (e.g., GLIMPSE, WISE, 2MASS, etc.), thereby enabling the construction of longer baseline spectral energy distributions for astronomical targets. However, in order to maximize use of the VVV data, a set of transformation equations are required to place the VVV JHKs photometry onto the 2MASS system. The impetus for this work is to develop those transformations via a comparison of 2MASS targets in 152 VVV fields sampling the Galactic disk. The transformation coefficients derived exhibit a reliance on variables such as extinction. The transformed data were subsequently employed to establish a mean reddening law of E_{J-H}/E_{H-Ks}=2.13 +/- 0.04, which is the most precise determination to date and merely emphasizes the pertinence of the VVV data for determining such important parameters.Comment: 24 pages, 12 figures, published in A&

Interfacing Neurons with Nanostructured Electrodes Modulates Synaptic Circuit Features

Understanding neural physiopathology requires advances in nanotechnology-based interfaces, engineered to monitor the functional state of mammalian nervous cells. Such interfaces typically contain nanometer-size features for stimulation and recording as in cell-non-invasive extracellular microelectrode arrays. In such devices, it turns crucial to understand specific interactions of neural cells with physicochemical features of electrodes, which could be designed to optimize performance. Herein, versatile flexible nanostructured electrodes covered by arrays of metallic nanowires are fabricated and used to investigate the role of chemical composition and nanotopography on rat brain cells in vitro. By using Au and Ni as exemplary materials, nanostructure and chemical composition are demonstrated to play major roles in the interaction of neural cells with electrodes. Nanostructured devices are interfaced to rat embryonic cortical cells and postnatal hippocampal neurons forming synaptic circuits. It is shown that Au-based electrodes behave similarly to controls. Contrarily, Ni-based nanostructured electrodes increase cell survival, boost neuronal differentiation, and reduce glial cells with respect to flat counterparts. Nonetheless, Au-based electrodes perform superiorly compared to Ni-based ones. Under electrical stimulation, Au-based nanostructured substrates evoke intracellular calcium dynamics compatible with neural networks activation. These studies highlight the opportunity for these electrodes to excite a silent neural network by direct neuronal membranes depolarization

Mutational status of K- ras and TP53 genes in primary sarcomas of the heart

We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K- ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K- ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types. © 2000 Cancer Research Campaig