4,852 research outputs found
Complex noise in diffusion-limited reactions of replicating and competing species
We derive exact Langevin-type equations governing quasispecies dynamics. The
inherent multiplicative noise has both real and imaginary parts. The numerical
simulation of the underlying complex stochastic partial differential equations
is carried out employing the Cholesky decomposition for the noise covariance
matrix. This noise produces unavoidable spatio-temporal density fluctuations
about the mean field value. In two dimensions, the fluctuations are suppressed
only when the diffusion time scale is much smaller than the amplification time
scale for the master species.Comment: 10 pages, 2 composite figure
Progress report on the ultra heavy cosmic ray experiment (AO178)
The Ultra Heavy Cosmic Ray Experiment (UHCRE) is based on a modular array of 192 side-viewing solid state nuclear track detector stacks. These stacks were mounted in sets of four in 48 pressure vessels employing sixteen peripheral Long Duration Exposure Facility (LDEF) trays. The extended duration of the LDEF mission has resulted in a greatly enhanced scientific yield from the UHCRE. The geometry factor for high energy cosmic ray nuclei, allowing for Earth shadowing, was 30 sq m-sr, giving a total exposure factor of 170 sq m-sr-y at an orbital inclination of 28.4 degrees. Scanning results indicate that about 3000 cosmic ray nuclei in the charge region with Z greater than 65 were collected. This sample is more than ten times the current world data in the field (taken to be the data set from the HEAO-3 mission plus that from the Ariel-6 mission) and is sufficient to provide the world's first statistically significant sample of actinide (Z greater than 88) cosmic rays. Results to date are presented including details of ultra-heavy cosmic ray nuclei, analysis of pre-flight and post-flight calibration events and details of track response in the context of detector temperature history. The integrated effect of all temperature and age related latent track variations cause a maximum charge shift of +/- 0.8 e for uranium and +/- 0.6 e for the platinum-lead group. The precision of charge assignment as a function of energy is derived and evidence for remarkably good charge resolution achieved in the UHCRE is considered. Astrophysical implications of the UHCRE charge spectrum are discussed
The LDEF ultra heavy cosmic ray experiment
The LDEF Ultra Heavy Cosmic Ray Experiment (UHCRE) used 16 side viewing LDEF trays giving a total geometry factor for high energy cosmic rays of 30 sq m sr. The total exposure factor was 170 sq m sr y. The experiment is based on a modular array of 192 solid state nuclear track detector stacks, mounted in sets of four in 48 pressure vessels. The extended duration of the LDEF mission has resulted in a greatly enhanced potential scientific yield from the UHCRE. Initial scanning results indicate that at least 1800 cosmic ray nuclei with Z greater than 65 were collected, including the world's first statistically significant sample of actinides. Post flight work to date and the current status of the experiment are reviewed
INTEGRAL timing and localization performance
In this letter we report on the accuracy of the attitude, misalignment, orbit
and time correlation which are used to perform scientific analyses of the
INTEGRAL data. The boresight attitude during science pointings has an accuracy
of 3 arcsec. At the center of the field, the misalignments have been calibrated
leading to a location accuracy of 4 to 40 arcsec for the different instruments.
The spacecraft position is known within 10 meters. The relative timing between
instruments could be reconstructed within 10 microsec and the absolute timing
within 40 microsec.Comment: 5 pages, 2 figures, accepted for publication in A+A letters, INTEGRAL
special issu
The Second INTEGRAL AGN Catalogue
The INTEGRAL mission provides a large data set for studying the hard X-ray
properties of AGN and allows testing of the unified scheme for AGN. We present
analysis of INTEGRAL IBIS/ISGRI, JEM-X, and OMC data for 199 AGN supposedly
detected by INTEGRAL above 20 keV. The data analysed here allow a significant
spectral extraction on 148 objects and an optical variability study of 57 AGN.
The slopes of the hard X-ray spectra of Seyfert 1 and Seyfert~2 galaxies are
found to be consistent within the uncertainties, whereas higher cut-off
energies and lower luminosities are measured for the more absorbed / type 2
AGN. The intermediate Seyfert 1.5 objects exhibit hard X-ray spectra consistent
with those of Seyfert 1. When applying a Compton reflection model, the
underlying continua appear the same in Seyfert 1 and 2 with photon index 2, and
the reflection strength is about R = 1, when assuming different inclination
angles. A significant correlation is found between the hard X-ray and optical
luminosity and the mass of the central black hole in the sense that the more
luminous objects appear to be more massive. There is also a general trend
toward the absorbed sources and type 2 AGN having lower Eddington ratios. The
black holemass appears to form a fundamental plane together with the optical
and X-ray luminosity of the form Lv being proportional to Lx^0.6 M^0.2, similar
to that found between radio luminosity Lr, Lx, and M. The unified model for
Seyfert galaxies seems to hold, showing in hard X-rays that the central engine
is the same in Seyfert 1 and 2, but seen under different inclination angles and
absorption. (Abridged)Comment: 26 pages, 16 figures, accepted for publication in A&A. Corrections by
language editor included in version
Projection to Latent Spaces Disentangles Pathological Effects on Brain Morphology in the Asymptomatic Phase of Alzheimer's Disease
Alzheimer’s disease (AD) continuum is defined as a cascade of several neuropathological
processes that can be measured using biomarkers, such as cerebrospinal fluid (CSF)
levels of Aβ, p-tau, and t-tau. In parallel, brain anatomy can be characterized through
imaging techniques, such as magnetic resonance imaging (MRI). In this work we relate
both sets of measurements and seek associations between biomarkers and the brain
structure that can be indicative of AD progression. The goal is to uncover underlying
multivariate effects of AD pathology on regional brain morphological information. For this
purpose, we used the projection to latent structures (PLS) method. Using PLS, we found
a low dimensional latent space that best describes the covariance between both sets
of measurements on the same subjects. Possible confounder effects (age and sex) on
brain morphology are included in the model and regressed out using an orthogonal PLS
model. We looked for statistically significant correlations between brain morphology and
CSF biomarkers that explain part of the volumetric variance at each region-of-interest
(ROI). Furthermore, we used a clustering technique to discover a small set of CSF-related
patterns describing the AD continuum. We applied this technique to the study of subjects
in the whole AD continuum, from the pre-clinical asymptomatic stages all the way through
to the symptomatic groups. Subsequent analyses involved splitting the course of the
disease into diagnostic categories: cognitively unimpaired subjects (CU), mild cognitively
impaired subjects (MCI), and subjects with dementia (AD-dementia), where all symptoms
were due to AD
Potential role for clinical calibration to increase engagement with and application of home telemonitoring: a report from the HeartCycle programme
Aims: There is a need for alternative strategies that might avoid recurrent admissions in patients with heart failure. Home Telemonitoring (HTM) to monitor patient’s symptoms from a distance may be useful. This study attempts to assess changes in HTM vital signs in response to daily life activities (variations in medication, salt intake, exercise and stress) and to stablish which variations affect weight, blood pressure (BP) and heart rate (HR). Methods and results: We assessed 76 patients with heart failure (mean age 76 ± 10.8 years, 75% male, mainly in NYHA class II/III and from ischaemic etiology cause). Patients were given a calendar of interventions scheduling activities approximately twice-a-week before measuring their vital signs. Eating salty food or a large meal were the activities that had a significant impact on weight gain (+0.3 kg; p<0.001 and p=0.006, respectively). Exercise and skipping a dose of medication other than diuretics increased heart rate (+3 bpm, p=0.001 and almost +2 bpm, p=0.016, respectively). Conclusions: Our HTM system was able to detect small changes in vital signs related to these activities. Further studies should assess if providing such a schedule of activities might be useful for patient education and could improve long-term adherence to recommended lifestyle changes
- …