THE ADAPTIVE RESPONSE AND PROTECTION AGAINST HERITABLE MUTATIONS AND FETAL MALFORMATION

There are a number of studies that show radiation can cause heritable mutations in the offspring of irradiated organisms. These “germ-line mutations” have been shown to occur in unique sequences of DNA called “minisatellite loci”. The high frequencies of spontaneous and induced mutations at minisatellite loci allow mutation induction to be measured at low doses of exposure in a small population, making minisatellite mutation a powerful tool to investigate radiation-induced heritable mutations. However, the biological significance of these mutations is uncertain, and their relationship to health risk or population fitness is unknown. We have adopted this mutation assay to study the role of adaptive response in protecting mice against radiation-induced heritable defects. We have shown that male mice, adapted to radiation with a low dose priming exposure, do not pass on mutations to their offspring caused by a subsequent large radiation exposure to the adapted males. This presentation and paper provide a general overview of radiationinduced mutations in offspring and explain the effect of low dose exposures and the adaptive response on these mutations. It is also known that exposure of pregnant females to high doses of radiation can cause death or malformation (teratogenesis) in developing fetuses. Malformation can only occur during a specialized stage of organ formation known as organogenesis. Studies in rodents show that radiation-induced fetal death and malformation can be significantly reduced when a pregnant female is exposed to a prior low dose of ionizing radiation. The mechanism of this protective effect, through an adaptive response, depends on the stage of organogenesis when the low dose exposures are delivered. To better understand this process, we have investigated the role of an important gene known as p53. Therefore, this report will also discuss fetal effects of ionizing radiation and explain the critical stages of development when fetuses are at risk. Research will be explained that investigates the biological and genetic systems (p53) that protect the developing fetus and discuss the role of low dose radiation adaptive response in these processes

Cut-wire pairs and plate pairs as magnetic atoms for optical metamaterials

We study the optical properties of metamaterials made from cut-wire pairs or plate pairs. We obtain a more pronounced optical response for arrays of plate pairs -- a geometry which also eliminates the undesired polarization anisotropy of the cut-wire pairs. The measured optical spectra agree with simulations, revealing negative magnetic permeability in the range of telecommunications wavelengths. Thus, nanoscopic plate pairs might serve as an alternative to the established split-ring resonator design.Comment: 3 pages, 4 figures, submitted to Opt. Let

Effect of dimples on glancing shock wave turbulent boundary layer interactions

An experimental study has been conducted to examine the control effectiveness of dimples on the glancing shock wave turbulent boundary layer interaction produced by a series of hemi-cylindrically blunted fins at Mach numbers 0.8 and 1.4, and at angles of sweep 0°, 15°, 30° and 45°. Schlieren photography, oil flow, pressure sensitive paints, and pressure tappings were employed to examine the characteristics of the induced flow field. The passive control technique used a series of 2 mm diameter, 1 mm deep indents drilled across the hemi-cylindrical leading edge at angles 0°, 45° and 90°. The effects of dimples were highly dependent on their orientation relative to the leading edge apex, and the local boundary layer properties

Planar designs for electromagnetically induced transparency in metamaterials

We present a planar design of a metamaterial exhibiting electromagnetically induced transparency that is amenable to experimental verification in the microwave frequency band. The design is based on the coupling of a split-ring resonator with a cut-wire in the same plane. We investigate the sensitivity of the parameters of the transmission window on the coupling strength and on the circuit elements of the individual resonators, and we interpret the results in terms of two linearly coupled Lorentzian resonators. Our metamaterial designs combine low losses with the extremely small group velocity associated with the resonant response in the transmission window, rendering them suitable for slow light applications at room temperature.Comment: 11 pages, 8 figure