Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the United Kingdom.

Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis affecting the aorta and its major branches. Although the disease rarely affects children, it does occur, even in infants. The objective of this study was to evaluate the clinical features, disease activity, treatment and outcome of childhood TA in a tertiary UK centre

Understanding the recovery of rare-earth elements by ammonium salts

While the recovery of rare earth elements (REEs) from aqueous solution by ionic liquids (ILs) has been well documented, the metal compounds that are formed in the organic phase remain poorly characterized. Using spectroscopic, analytical, and computational techniques, we provide detailed chemical analysis of the compounds formed in the organic phase during the solvent extraction of REEs by [(n-octyl)3NMe][NO3] (IL). These experiments show that REE recovery using IL is a rapid process and that IL is highly durable. Karl-Fischer measurements signify that the mode of action is unlikely to be micellar, while ions of the general formula REE(NO3)4(IL)2− are seen by negative ion electrospray ionization mass spectrometry. Additionally, variable temperature 139La nuclear magnetic resonance spectroscopy suggests the presence of multiple, low symmetry nitrato species. Classical molecular dynamics simulations show aggregation of multiple ILs around a microhydrated La3+ cation with four nitrates completing the inner coordination sphere. This increased understanding is now being exploited to develop stronger and more selective, functionalized ILs for REE recovery

Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis

Export Date: 16 February 2023; Cited By: 10Peer reviewe

MOOC Cubes and Clouds - Cloud Native Open Data Sciences for Earth Observation

The "Cubes and Clouds" Massive Open Online Course (MOOC) addresses the growing challenges and opportunities in Earth Observation (EO) data analysis posed by the exponential growth of satellite missions and data volumes. This course introduces cloud-native EO concepts and open science principles, facilitating collaboration and data sharing within the EO community.Key topics covered in the MOOC include data discovery, processing workflows, and data sharing using real-world examples like snow cover mapping in the Alps. Participants engage with interactive lessons, videos, and hands-on coding exercises, leveraging freely available geospatial data and emphasizing open data principles and interoperability.The course infrastructure seamlessly integrates with cloud platforms like the Copernicus Data Space Ecosystem, enabling learners to apply concepts in a practical, cloud-based environment. Initial user statistics indicate strong interest, particularly among early-career professionals and researchers, with participant surveys suggesting increased confidence in using EO cloud platforms and embracing open science practices upon course completion.Overall, "Cubes and Clouds" serves as a valuable resource for the EO community, fostering transparency, collaboration, and innovation in geospatial science. Future developments aim to expand course content and attract diverse user groups, ensuring broader accessibility and long-term impact in advancing cloud-native EO and open science initiatives