Export Date: 16 February 2023; Cited By: 10Peer reviewe

Alongi, Alessandra

Avcin, T.

Consolaro, Alessandro

Dolezalova, P.

Garrone, M.

Lahdenne, Pekka

Mazzoni, M.

Nikishina, I.

Panaviene, V.

Pruunsild, C.

Quartier, P.

Ravelli, A.

Ringold, S.

Ruperto, N.

Rutkowska-Sak, L.

Swart, J.F.

Trincianti, Chiara

Uziel, Y.

Van Dijkhuizen, Evert Hendrik Pieter

Vargova, V.

Vilaiyuk, S.

English

PubMed

Objective: To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor–negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist. Methods: The cutoffs definition cohort was composed of 1,936 patients included in the multinational Epidemiology, Treatment and Outcome of Childhood Arthritis (EPOCA) study. Using the subjective physician rating as an external criterion, 4 methods were applied to identify the cutoffs: mapping, Youden index, 90% specificity, and maximum agreement. The validation cohort included 4,014 EPOCA patients, patients from 2 randomized trials, and 88 patients from the PharmaChild registry. Cutoff validation was conducted by assessing discriminative and predictive ability. Results: The JADAS10 cutoffs were 1.4, 4, and 13, respectively, for oligoarthritis and 2.7, 6, and 17, respectively, for polyarthritis. The cJADAS10 cutoffs were 1.1, 4, and 12, respectively, for oligoarthritis and 2.5, 5, and 16, respectively, for polyarthritis. The cutoffs discriminated strongly among different levels of pain and morning stiffness, between patients who were and those who were not prescribed a new medication, and between different levels of improvement in clinical trials. Achievement of ID and MiDA according to the new JADAS cutoffs at least twice in the first year of disease predicted better outcome at 2 years. Conclusion: The 2021 JADAS and cJADAS cutoffs revealed good metrologic properties in both definition and validation samples, and are therefore suitable for use in clinical trials and routine practice

Trincianti, Chiara,

Van Dijkhuizen, Evert Hendrik Pieter,

Alongi, Alessandra,

Mazzoni, Marta,

Swart, Joost F.,

Nikishina, Irina,

Lahdenne, Pekka,

Rutkowska-Sak, Lidia,

Avcin, Tadej,

Quartier, Pierre,

Panavienė, Violeta Vladislava,

Uziel, Yosef,

Pruunsild, Chris,

Vargova, Veronika,

Vilaiyuk, Soamarat,

Dolezalova, Pavla,

Ringold, Sarah,

Garrone, Marco,

Ruperto, Nicolino,

Ravelli, Angelo,

Consolaro, Alessandro,

Vilnius University Institutional Repository

Definition and validation of the American College of Rheumatology 2021 juvenile arthritis disease activity score cutoffs for disease activity states in juvenile idiopathic arthritis /

Chiara Trincianti

Evert Hendrik Pieter Van Dijkhuizen

Alessandra Alongi

Marta Mazzoni

Joost F. Swart

Irina Nikishina

Pekka Lahdenne

Lidia Rutkowska‐Sak

Tadej Avcin

Pierre Quartier

Violeta Panaviene

Yosef Uziel

Chris Pruunsild

Veronika Vargova

Soamarat Vilaiyuk

Pavla Dolezalova

Sarah Ringold

Marco Garrone

Nicolino Ruperto

Angelo Ravelli

Alessandro Consolaro

Crossref

Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis

Helsingin yliopiston digitaalinen arkisto

Trincianti C.

Van Dijkhuizen E. H. P.

Alongi A.

Mazzoni M.

Swart J. F.

Nikishina I.

Lahdenne P.

Rutkowska-Sak L.

Avcin T.

Quartier P.

Panaviene V.

Uziel Y.

Pruunsild C.

Vargova V.

Vilaiyuk S.

Dolezalova P.

Ringold S.

Garrone M.

Ruperto N.

Ravelli A.

Consolaro A.

Archivio istituzionale della ricerca - Università di Genova

Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis

Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis

Abstract

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Vilnius University Institutional Repository

Crossref

Helsingin yliopiston digitaalinen arkisto

Archivio istituzionale della ricerca - Università di Genova