Perancangan Bisnis Online Sewatempat.com

Berdasarkan data statistik jumlah penduduk yang membutuhkan tempat tinggal dan kebutuhan atas tempat USAha semakin meningkat. Diimbangi dengan bertambahnya pengguna internet di Indonesia hingga ke pelosok daerah, sehingga penulis melihat adanya peluang bisnis online untuk sewa properti. Metodologi yang digunakan untuk melihat peluang bisnis tersebut memakai analisis SWOT, Porter 5 Forces, Segmentation-Targeting-Positioning (STP) dan Marketing Mix 4P. Dari metodologi yang digunakan, sehingga dapat menunjang dalam pembuatan Business Plan yang feasible dan profitable. Dilihat dari analisis keuangan untuk nilai IRR sebesar 20% dan ROI sebesar 28%

Implementation of Bai ‘Bitsaman Ajil (Baa) Financing to Increasing Income on Bmt At-taqwa Muhammadiyah Bandar Buat Branch

The purpose of this study is to describe the procedure for the implementation of Bai 'Bitsaman Ajil (BBA) financing at BMT Taqwa Muhammadiyah Branch Bandar Buat. The data source of this study was obtained from the manager of BMT Taqwa Muhammadiyah Bandar Bandar branch. Based on the results of the research conducted by the author, that BMT At-Taqwa Muhammadiyah Bandar Buat Branch has established a financing procedure that must be met by each prospective customer starting with the customer submitting a request for financing, the Account Officer (AO) conducts a survey to the place of business and residence, Account Officer (AO) calculates customer cash flaw (cash flow), realization of financing proposals, and the latter pays installments to BM

Pengaruh Struktur Modal, Profitabilitas dan Ukuran Perusahaan terhadap Nilai Perusahaan (Studi pada Perusahaan Properti dan Real Estate di Bursa Efek Indonesia Tahun 2010-2012)

Issues that are examined in this study is the effect of capital structure , profitability , and firm size on firm value . The purpose of this study was to analyze the effect of capital structure , profitability , and firm size on firm value .The type of research is descriptive and associative . The population of this entire property and real estate companies listed on the Indonesia Stock Exchange totaling 45 companies . The sampling technique specified by purposive sampling so as to 27 companies that will be sampled . The data used in this study is a secondary data . Dependent variable and the independent variable value of the company s capital structure , profitability and firm size . The analysis model is a multiple linear regression analysis .Results obtained from testing the hypothesis that : First , capital structure does not significantly influence the value of the company with sig 0.539 > α = 0.05 . Second , profitability significantly influence the value of the company with sig 0.001 < α = 0.05 . Third , firm size significantly influence the value of the company with sig 0.008 < α = 0.05 . Fourth , capital structure , profitability and firm size significantly influence the value of the company with sig 0.001 < α = 0.05 .Based on the research results , the researchers suggest the company 1. Order to maintain its capital structure in order to give effect to the value of the company. 2. Order to continue to improve profitability by increasing profits that will affect the profitability of the increase in value of the company . In addition the company also must keep the asset because the asset will increase the value of the total assets of the ions so the size of the company will be high which will give a positive effect on firm value

Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity

Imbalance of iron homeostasis has been reported in sporadic Creutzfeldt-Jakob-disease (sCJD) affected human and scrapie infected animal brains, but the contribution of this phenotype to disease associated neurotoxicity is unclear.Using cell models of familial prion disorders, we demonstrate that exposure of cells expressing normal prion protein (PrP(C)) or mutant PrP forms to a source of redox-iron induces aggregation of PrP(C) and specific mutant PrP forms. Initially this response is cytoprotective, but becomes increasingly toxic with time due to accumulation of PrP-ferritin aggregates. Mutant PrP forms that do not aggregate are not cytoprotective, and cells show signs of acute toxicity. Intracellular PrP-ferritin aggregates induce the expression of LC3-II, indicating stimulation of autophagy in these cells. Similar observations are noted in sCJD and scrapie infected hamster brains, lending credence to these results. Furthermore, phagocytosis of PrP-ferritin aggregates by astrocytes is cytoprotective, while culture in astrocyte conditioned medium (CM) shows no measurable effect. Exposure to H(2)O(2), on the other hand, does not cause aggregation of PrP, and cells show acute toxicity that is alleviated by CM.These observations suggest that aggregation of PrP in response to redox-iron is cytoprotective. However, subsequent co-aggregation of PrP with ferritin induces intracellular toxicity unless the aggregates are degraded by autophagosomes or phagocytosed by adjacent scavenger cells. H(2)O(2), on the other hand, does not cause aggregation of PrP, and induces toxicity through extra-cellular free radicals. Together with previous observations demonstrating imbalance of iron homeostasis in prion disease affected brains, these observations provide insight into the mechanism of neurotoxicity by redox-iron, and the role of PrP in this process

A Fuzzy Controlled LCC HVDC System with AC Voltage and Reactive Power Control

The main work focus is on the LCC HVDC reactive power control system with fluid regulated AC voltage. The reactive power and the voltage control capacity of LCC HVDC were examined and demonstrated with controlled condensers. Reactive power control and voltage management have been suggested and associated controllers with variable condensers have been developed on the reverse side of the fuzzy controlled LCC HVDC system. The active corrective side power control is required and a reactive or voltage control has been taken into account in this work. This study looks at the inverter side of the system LCC HVDC with customizable capacitors, reactive power and fluid management of the AC voltage. The usual AC voltage control and PI controller for reactive power is replaced by an injected controller that enhances reaction speed and control. In the MATLAB software with Sim-Power system toolbox, graphs are created using a GUI environment to model the proposed fuzzy-controlled HVDC system

Generation of Oxygenating Fluorinated Methacrylamide Chitosan Microparticles to Increase Cell Survival and Function in Large Liver Spheroids

Despite advances in the development of complex culture technologies, the utility, survival, and function of large 3D cell aggregates, or spheroids, are impeded by mass transport limitations. The incorporation of engineered microparticles into these cell aggregates offers a promising approach to increase spheroid integrity through the creation of extracellular spaces to improve mass transport. In this study, we describe the formation of uniform oxygenating fluorinated methacrylamide chitosan (MACF) microparticles via a T-shaped microfluidic device, which when incorporated into spheroids increased extracellular spacing and enhanced oxygen transport via perfluorocarbon substitutions. The addition of MACF microparticles into large liver cell spheroids supported the formation of stable and large spheroids (\u3e500 μm in diameter) made of a heterogeneous population of immortalized human hepatoma (HepG2) and hepatic stellate cells (HSCs) (4 HepG2/1 HSC), especially at a 150:1 ratio of cells to microparticles. Further, as confirmed by the albumin, urea, and CYP3A4 secretion amounts into the culture media, biological functionality was maintained over 10 days due to the incorporation of MACF microparticles as compared to controls without microparticles. Importantly, we demonstrated the utility of fluorinated microparticles in reducing the number of hypoxic cells within the core regions of spheroids, while also promoting the diffusion of other small molecules in and out of these 3D in vitro models