Morphology of the Human Pineal Gland in Relation to Age and Sex

Plasma concentration of melatonin - the hormone secreted by the human pineal gland is highest in children between 1 and 3 years of age. In the next age groups its levels decrease and in adults they are by approximately 80% lower. These drastic age differences in the function of the pineal gland made us hypothesize that some structural differences in it related to age and sex can be expected. The aim of this study was to investigate the macroscopic and microscopic characteristics of the pineal gland in relation to age and sex. Some 126 pineal glands were observed and histologically studied. Of them, 87 were taken from men and 37 from women with mean age of 52,65 (from 20 to 95) years. Slices of 5 µ were cut from paraffin blocks, stained with hematoxylin and eosin and microscopically examined. Data was analysed with standard statistical procedures. No gender-related differences in the macroscopic characteristics and the histologic structure of the pineal gland were identified. Age was not related to the macroscopic characteristics of the pineal gland, too. However, some differences in the histologic structure of the gland in relation to age were observed. Partially defined pseudolobs prevailed in the glands of younger people, while with increasing age glands with well-defined pseudolobs were more common

Structural Changes in the Human Pineal Gland in Cases of Fibrosing Capsule

The capsule and its trabeculae are an active element of the human pineal gland's structure. During the examination of section material we observed that in part if the pineal glands the capsule was thickened and with fibrosis (TFC). The literature review as well as our observations made us to undertake the current study with the aim tofind out what is the role of the thick and fibrotic capsule on the macroscopic characteristics and the main histologic structures of the human pineal gland. We studied 134 pineal glands taken from bodies of people who died from both non-violent and violent cause of death. 95 of the pineal glands were taken from men and 39 from women, with mean age 52,57 years. Slices 5 µ thick were stained with hematoxylin and eosin and Van Gieson. The material was examined on light microscope and results analyzed with standard statistical methods. Cases with TFC represent 43,08% of all studied pineal glands. There is no statistically significant difference in the percentage of cases with TFC between the groups of those who died at 20-39 years of age and 40 and above. There is no statistically significant difference in the percentage of cases with TFC among men and women. The length width and weight of pineal glands with fibrose capsulae are bigger. Density is not changed. The percentage with gliosis is higher in the group of pineal glands with gentle capsulae. The rest of the variables are without changes

CYTOCHEMICAL INVESTIGATIONS OF MANGANESE IN BLOOD CELLS IN DIABETES MELLITUS (Preliminary communication)

No abstrac

STUDY OF THE ACUTE TOXICITY AND COMBINED ACTION OF THE PESTICIDES ACREX AND ACTELIC

No abstrac

Acute aortic dissection - forensic medicine aspects

Wem investigated some forensic-edical aspects and medico-biological aspects of aortic aneurisms. We examined 2574 forensic autopsies from 1998 to 2004 years. There were studied the following data - sex, age, reasons for the development of the aneurysms, the localization of the intimal lesions, complications and chronobiological pecularities. The level of alcohol were established by Widmark method. We found 20 cases with acute aortic dissection aneurysms (0,78%). The most often place of death is home (45%) and work (20%). The men were more than twice (70% men and 30% women). The average age of the men (55,71) was considerably lower than women's (68,67). The most affected age group (50-79) occupied 75% from all cases. The main etiologic factor was hypertonia and atherosclerosis (70%), in 20% - only hypertonia. We observed intimal lesions 1 sm and 2 sm above aortic valve. The wall of the left ventricle with hypertonia and atherosclerosis showed 21,86 mm. In 85% of the cases we found cardiac tamponada. There were chronobiological peculiarities in sudden death from aortic aneurysms

Analysis of fatal electrical traumas in the region of Varna for a 41-year-long period

Introduction. Electrotraumatism (ET) is rare to observe, but it presents a significant problem both for public health and forensic medicine. Purpose. The purpose of this study is to identify some features and circumstances typical of ET on the territory of Varna District. Material and methods. Forensic medicine documentation has been examined from 16780 autopsies for the period 1965-2005 performed at the Chair of Forensic Medicine and Deontology, the Medical University of Varna. The results have been processed by the statistical methods of alternative, variational and graphical analysis. Results. Over the 41-year-long period, a total of 280 ET autopsies have been performed, which accounts for 1.67% (Δ±D1, 5) of all autopsies. Lethal injuries by electric current typically occur in young age. Young males prevail. More than half of the events have been domestic ET. In the studied group, the number of accidents caused by high voltage is about the same as the number of accidents caused by low voltage. Suicide by electric current is relatively rare. A forensic medicine expert participated in 99 (62.26% Δ±D9.55) of the inspections on the scene of accident. Conclusions. ET affects mainly young males in domestic ET.Scripta Scientifica Medica 2008; 40(2): 177-178

Etude histoenzymologique des mitoses de type normal et anormal dans les tumeurs intracrâniennes

info:eu-repo/semantics/publishe

Sudden infant death syndrome - the cause of death

Studies on the potential role of agents in SIDS have been published over the years in a variety of journals and involved specific microorganisms, sleeping position, dysfunction of the central nervous system, damaged arousal reflex cigarette smoking, lower socioeconomic way of life, specific age. Although, there aren't criteria to established specific risk factors. SIDS still remains unexplained in spite of thorough case investigation, including complete autopsy, examination of the death scene and review of the clinical history. Our humble contribution to this problem included 12 sudden death cases in babies from 20 days to 1 year. We may place our cases in the group of unexpected explained death, because the main cause of death in most babies is pneumonia. The histological changes in lungs were microhemorrhages in alveoles and interstitium, congestion, oedema, pulmonary emphysema, atelectases, hemosiderin-laden macrophages, bronchitis and catharral-desquamating pneumonia or catharral hemorrhagic pneumonia, but in two cases there were a purulent pneumonia. In conclusion most authors consider no laboratory or pathological tests to establish a diagnosis of SIDS and no lesions are found at autopsy in most cases. However, as recent reports pointed out, the affected infant would not be perfectly well before death. Most authors pointed the histopathological changes in lungs that we established and pointed above.Scripta Scientifica Medica 2008; 40(2): 171-174