985 research outputs found
Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide: Pharmacological Concerns of Side Effects
Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QTc-prolongation, somnolence, and hyperglycemia. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide. Symptoms associated with intoxication were coma without arterial hypotension, persistent tachycardia, hyperglycemia, and transient hypothyreoidism. QTc-interval was moderately extended. Management consisted of intubation for airway protection, gastric lavage, the use of activated charcoal, i.v. saline, and observation for 17 hours on an intensive care unit. Despite the extremely high dose of quetiapine, the patient recovered completely without residual symptoms
ДОСЛІДЖЕННЯМ.КОСТОМАРОВА З
На основі наукових праць та досліджень М.І.Костомарова розглянуто історію взаємин
українського козацтва та уряду Речі Посполитої в другій половині 1590-х – середині 1620-х
років. Підкреслюється особливе значенняпраць історика та йогодослідженнь в галузі вивчення
історії козацтва та історіографії даної проблеми.On thebasis ofscientific labours and researches ofM.I.Kostomarovofmutualrelations of Ukrainian
the cossacks and government of Polish-Lithuanian Commonwealth is considered in the second half
1590 – the middle 1620 years. The special value of labours of historian is underlined and and his
researches in industry of study of history of the cossacks and historiography of this problem
Extreme magnesium isotope fractionation at outcrop scale records the mechanism and rate at which reaction fronts advance
Isotopic fractionation of cationic species during diffusive transport provides novel means of constraining the style and timing of metamorphic transformations. Here we document a major (~1‰) decrease in the Mg isotopic composition of the reaction front of an exhumed contact between rocks of subducted crust and serpentinite, in the Syros mélange zone. This isotopic perturbation extends over a notable length-scale (~1 m), implicating diffusion of Mg through an intergranular fluid network over a period of ~100 kyr. These novel observations confirm models of diffusion-controlled growth of reaction zones formed between rocks of contrasting compositions, such as found at the slab-mantle interface in subduction zones. The results also demonstrate that diffusive processes can result in exotic stable isotope compositions of major elements with implications for mantle xenoliths and complex intrusions
Finite-Difference Time-Domain Simulation for Three-dimensional Polarized Light Imaging
Three-dimensional Polarized Light Imaging (3D-PLI) is a promising technique
to reconstruct the nerve fiber architecture of human post-mortem brains from
birefringence measurements of histological brain sections with micrometer
resolution. To better understand how the reconstructed fiber orientations are
related to the underlying fiber structure, numerical simulations are employed.
Here, we present two complementary simulation approaches that reproduce the
entire 3D-PLI analysis: First, we give a short review on a simulation approach
that uses the Jones matrix calculus to model the birefringent myelin sheaths.
Afterwards, we introduce a more sophisticated simulation tool: a 3D Maxwell
solver based on a Finite-Difference Time-Domain algorithm that simulates the
propagation of the electromagnetic light wave through the brain tissue. We
demonstrate that the Maxwell solver is a valuable tool to better understand the
interaction of polarized light with brain tissue and to enhance the accuracy of
the fiber orientations extracted by 3D-PLI.Comment: 13 pages, 5 figure
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