Experimental investigation of time-dependent local scour downstream of a stepped channel

In this study, temporal variation of local scour occurring at the downstream part of the stepped channel were investigated experimentally. The experimental tests were carried out in a stepped flume with a height of 2.4 m. The width of the rectangular flume was 0.10 m and the length of the stilling basin was 2.12 m. Bed material was placed in a sediment box with a height of 24 cm and length of 2.48 m, without any compaction. Experiments were carried out by using bed material of 4 different grain size distributions, 2 different sill heights and 6 different flow rates. Two empirical equations which include Shields parameter (θ) and densimetric Froude particle number (Fd) were proposed by using the experimental findings to predict the temporal variation of the scour depth. The R2 (coefficient of determination) values were computed for both proposed equations as 0.866 and 0.865. The scatter index (SI) values were also determined and computed as 8.73% and 8.25%. The fit of the equations was also determined by means of Fisher’s test.Keywords: stepped channel, local scour, temporal variatio

Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and the limit of detection and quantification were 1.25 and 3.77 μg mL–1 Optimized CE . method was validated on the basis of related ICH guideline and found as an accurate, sensitive, precise and reproducible method for cabergoline determination. Developed method is also successfully applied for the analysis of pharmaceutical preparations containing cabergoline.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Spectrophotometric analysis of Cabergoline in pharmaceutical preparations

Cabergoline (CAB) is a synthetic ergoline dopamine agonist with high affinity to D2 receptors, thus used for the treatment of Parkinson's patients and hyperprolactinemia disorders. In this study, simple, fast, reliable and validated UV-VIS and 2nd order derivative spectrophotometric methods for determination of CAB in pharmaceutical preparations were developed without any previous sample preparation step. Determination of CAB was performed at 280 nm wavelength by UV-VIS spectrophotometry and in the range of 227-232 nm by 2nd order derivative spectrophotometry. Developed both spectrophotometric methods were linear over the range of CAB concentrations from 1 to 125 µg mL-1-. The highest relative error and relative standard deviation in within-day and day-to-day study for UV-VIS spectrophotometry were found to be 1.10% and 0.63%, respectively. The relative error and relative standard deviation in within-day and day-to-day study for 2nd order derivative spectrophotometry were not higher than 1.10% and 0.70%, respectively.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Civil Society Monitoring Report 2012

TUSEV published the first Civil Society Monitoring Report in 2011 in order to more closely observe and evaluate developments in the area of civil society. The purposes of this report are for civil society to be recognized, better understood and bring awareness to challenges faced, as well as portraying developments over the past ten years. We believe that the favorable assessment of the Civil Society Monitoring Report by the representatives of civil society and the various institutions in the international arena is a significant progress. The Civil Society Monitoring Report 2012 presents the developments and achievements in the area of civil society, as well as the shortcomings and difficulties observed in practice within the period of 2011-2012. Also, the report compares findings of this year with the previous year

Wpływ hormonalnej terapii zastępczej oraz tamoxifenu na depresję u szczurów poddanych usunięciu jajników

Objectives: To determine the effects of tamoxifen and hormone replacement therapy in order to assess their role in depressive behavior. Material and Methods: Different protocols of hormone replacement therapies were administered to surgically ovariectomized rats. Intact rats were used for tamoxifen experiments. Properly assigned control groups were used and cognitive processes were studied on animal models of surgical menopause using the Porsolt Forced Swim Test and locomotor activity experiments. Results: In the tamoxifen experiments, an interaction between treatment and days did not reach statistical significance, but indicated a trend in this direction [F(1,26)=3.557, p=0.071]. The number of repeated movements significantly decreased after the Porsolt test (F(1,44) = 8.483, PCel: Określenie wpływu tamoxifenu oraz hormonalnej terapii zastępczej celem oceny ich roli w zachowaniach depresyjnych. Materiał i metody: Różne protokoły hormonalnej terapii zastępczej zastosowano u szczurów poddanych chirurgicznemu usunięciu jajników. Tamoxifen podawano szczurom, których nie operowano. Wykorzystano odpowiednio dobraną grupę kontrolną. Zbadano procesy poznawcze na modelach zwierzęcych z chirurgiczną menopauzą przy pomocy testu Porsolt Forced Swim oraz doświadczeń aktywności ruchowej. Wyniki: W doświadczeniach z tamoxifenem, związek pomiędzy terapią a dniami nie osiągnął statystycznej istotności, ale wykazał trend w tym kierunku [F(1,26)=3,557,p=0,071]. Liczba powtórzeń ruchów istotnie zmniejszyła się po teście Porsolta [F(1,44)=8,483,

Water recovery with combined membrane system in textile industry, treatment and management of concentrates by hybrid advanced oxidation/membrane filtration

In this study, in addition to textile wastewater treatment by UF/NFtight/TO membrane combination of which efficiency is known, management has been performed for membrane concentrates generated with advanced oxidation combined process (Fenton and photo-Fenton (UVA-365-UVC-254))/submerged UF system of membrane concentrates generated within 75-80% water recovery ratio by oxidizing them in optimum operating conditions which were determined before. Ultimately in the studies, the conclusion has been reached that concentrate flows, generated as a result of the treatment with UF/NFtight/TO membrane configuration, were the highest performance innovative process by decreasing the sequential operated photo-Fenton (UVC-254)/UH050 hybrid process in ratios of 9.88 H2O2/TOK and 7.27 H2O2/Fe2+, in the filtration flux of 44 L/m(2). h, COD value to 167 mg/L with 86% COD removal, and TOK value to 104 mg/L with 74.2% TOC removal, after the oxidation with Fenton, photo-Fenton (UVA-365) and (UVC-254)/submerged UF system processes. When hazardous characteristics, removal/recovery methods and reuse alternatives of the concentrate remained after the oxidation of membrane concentrates generated were evaluated, it has been seen that all other concentrates of textile industry wastewater, except the concentrate generated by the treatment with photo-Fenton (UVA-365), had characteristics of hazardousness When removal/recovery methods were evaluated in detail, the conclusion has been reached that these concentrates could be removed with alternative options such as regular storage, burning and canalizing to central wastewater treatment system as long as necessary arrangements (moisture content, dehydration, suitable flow and/or mixture ratios) are made

Congenital Agenesis of Right Internal Carotid Artery: A Report of Two Cases

Congenital unilateral agenesis of the internal carotid artery (ICA) is a rare anomaly. Due to proper sufficient collateral circulation via the circle of Willis most cases are asymptomatic, but patients can also present with ischemic or hemorrhagic cerebrovascular insults. The absence of the bony carotid canal is essential to differentiate this anomaly from chronic ICA occlusion. Awareness of this situation by clinicians and radiologists is essential because these patients have an increased incidence of various intracranial pathologies. We report two cases of this rare developmental congenital abnormality occurring in two young patients and describe the presentation, diagnosis, determined developmental causes, imaging findings, and complications

Growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow’s milk protein allergy

ObjectiveTo evaluate growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula (eHCF) in infants with cow’s milk protein allergy (CMPA).MethodsA total of 226 infants (mean ± SD age: 106.5 ± 39.5 days, 52.7% were girls) with CMPA who received eHCF comprising at least half of the daily dietary intake were included. Data on anthropometrics [weight for age (WFA), length for age (LFA) and weight for length (WFL) z-scores] were recorded at baseline (visit 1), while data on infant feeding and stool records, anthropometrics and Infant Feeding and Stool Patterns and Formula Satisfaction Questionnaires were recorded at visit 2 (on Days 15 ± 5) and visit 3 (on Days 30 ± 5).ResultsFrom baseline to visit 2 and visit 3, WFA z-scores (from −0.60 ± 1.13 to −0.54 ± 1.09 at visit 2, and to −0.44 ± 1.05 at visit 3, p < 0.001) and WFL z-scores (from −0.80 ± 1.30 to −0.71 ± 1.22 at visit 2, and to −0.64 ± 1.13 at visit 3, p = 0.002) were significantly increased. At least half of infants never experienced irritability or feeding refusal (55.7%) and spit-up after feeding (50.2%). The majority of mothers were satisfied with the study formula (93.2%), and wished to continue using it (92.2%).ConclusionsIn conclusion, eHCF was well-accepted and tolerated by an intended use population of infants  ≤ 6 months of age with CMPA and enabled adequate volume consumption and improved growth indices within 30 days of utilization alongside a favorable gastrointestinal tolerance and a high level of parental satisfaction