1,665 research outputs found
Black-Box Complexity: Breaking the Barrier of LeadingOnes
We show that the unrestricted black-box complexity of the -dimensional
XOR- and permutation-invariant LeadingOnes function class is . This shows that the recent natural looking bound is
not tight.
The black-box optimization algorithm leading to this bound can be implemented
in a way that only 3-ary unbiased variation operators are used. Hence our bound
is also valid for the unbiased black-box complexity recently introduced by
Lehre and Witt (GECCO 2010). The bound also remains valid if we impose the
additional restriction that the black-box algorithm does not have access to the
objective values but only to their relative order (ranking-based black-box
complexity).Comment: 12 pages, to appear in the Proc. of Artificial Evolution 2011, LNCS
7401, Springer, 2012. For the unrestricted black-box complexity of
LeadingOnes there is now a tight bound, cf.
http://eccc.hpi-web.de/report/2012/087
Enhancement of Opioid-Mediated Analgesia\ud by Ingestion of Amniotic Fluid:\ud Onset Latency and Duration
Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia produced by morphine injection, footshock, vaginal/cervical stimulation, and during late pregnancy in rats. The present study was designed to determine how soon after ingestion the enhancement begins and how long it lasts. Tail-flick latencies in Long-Evans rats were determined before and during vaginal/cervical stimulation; analgesia was measured as the percent increase in tail-flick latency during vaginal stimulation. After determination of baseline, rats were intubated with 0.25 ml of either amniotic fluid or beef bouillon. We found that analgesia enhancement was detectable as early as 5 minutes after ingestion of amniotic fluid, and the effect lasted at least 30 minutes, but no longer than 40 minutes
Amniotic-Fluid Ingestion Enhances\ud Morphine Analgesia During Morphine\ud Tolerance and Withdrawal in Rats
Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia in rats produced by morphine injection. footshock, vaginal/cervical stimulation, and during late pregnancy. The present study was designed to investigate the effects of amniotic fluid ingestion on the characteristics of morphine dependency and withdrawal. Tail-flick latencies in Long-Evans rats were determined before and after repeated daily injections of morphine sulfate. It was found that ingestion of amniotic fluid after establishment of the morphine dependency, coupled with an injection of an otherwise ineffective dose of morphine, enhanced analgesia in morphine-dependent rats, and reversed hyperalgesia seen during withdrawal from morphine dependency
Ingested bovine amniotic fluid enhances morphine antinociception in rats
Ingestion by rats of rat placenta or amniotic fluid enhances opioid-mediated, or partly opioid-mediated, antinociception produced by morphine injection, vaginal or cervical stimulation, late pregnancy, and foot shock. This phenomenon is believed to be produced by a placental\ud
opioid-enhancing factor (POEF). Ingestion by rats of human or dolphin placenta has also been shown to enhance opioid antinociception, suggesting that POEF may be common to many mammalian species. We tested bovine amniotic fluid (BAF) for its capacity to enhance morphine antinociception in female Long-Evans rats, as determined by percentage change from baseline tail-flick latency in response to radiant heat, and we report that 0.50 mL BAF effectively enhanced morphine antinociception but did not by itself produce antinociception. The efficacy of POEF across species suggests that POEF may have been functionally (and structurally) conserved during evolution. Furthermore, the availability of POEF at parturition, as well as its ability to enhance pregnancy-mediated antinociception without\ud
disrupting maternal behavior, offers a tenable explanation for the long-debated ultimate causality of placentophagia
Searching for Radio Pulsars in 3EG Sources at Urumqi Observatory
Since mid-2005, a pulsar searching system has been operating at 18 cm on the
25-m radio telescope of Urumqi Observatory. Test observations on known pulsars
show that the system can perform the intended task. The prospect of using this
system to observe 3EG sources and other target searching tasks is discussed.Comment: a training project about MSc thesi
Hybridizing the 1/5-th Success Rule with Q-Learning for Controlling the Mutation Rate of an Evolutionary Algorithm
It is well known that evolutionary algorithms (EAs) achieve peak performance
only when their parameters are suitably tuned to the given problem. Even more,
it is known that the best parameter values can change during the optimization
process. Parameter control mechanisms are techniques developed to identify and
to track these values.
Recently, a series of rigorous theoretical works confirmed the superiority of
several parameter control techniques over EAs with best possible static
parameters. Among these results are examples for controlling the mutation rate
of the ~EA when optimizing the OneMax problem. However, it was
shown in [Rodionova et al., GECCO'19] that the quality of these techniques
strongly depends on the offspring population size .
We introduce in this work a new hybrid parameter control technique, which
combines the well-known one-fifth success rule with Q-learning. We demonstrate
that our HQL mechanism achieves equal or superior performance to all techniques
tested in [Rodionova et al., GECCO'19] and this -- in contrast to previous
parameter control methods -- simultaneously for all offspring population sizes
. We also show that the promising performance of HQL is not restricted
to OneMax, but extends to several other benchmark problems.Comment: To appear in the Proceedings of Parallel Problem Solving from Nature
(PPSN'2020
Evolutionary Algorithms with Self-adjusting Asymmetric Mutation
Evolutionary Algorithms (EAs) and other randomized search heuristics are
often considered as unbiased algorithms that are invariant with respect to
different transformations of the underlying search space. However, if a certain
amount of domain knowledge is available the use of biased search operators in
EAs becomes viable. We consider a simple (1+1) EA for binary search spaces and
analyze an asymmetric mutation operator that can treat zero- and one-bits
differently. This operator extends previous work by Jansen and Sudholt (ECJ
18(1), 2010) by allowing the operator asymmetry to vary according to the
success rate of the algorithm. Using a self-adjusting scheme that learns an
appropriate degree of asymmetry, we show improved runtime results on the class
of functions OneMax describing the number of matching bits with a fixed
target .Comment: 16 pages. An extended abstract of this paper will be published in the
proceedings of PPSN 202
Ingested placenta blocks the effect of morphine on gut transit in LongâEvans rats
Opioids produce antinociception, and ingested placenta or amniotic fluid modifies that antinociception. More specifically, ingested placenta enhances the antinociception produced by selective activation of central n-opioid or y-opioid receptors but attenuates that produced by activation of central A-opioid receptors. Opioids also slow gut transit by acting on central or peripheral A-opioid receptors. Therefore, we hypothesized that ingested placenta would reverse the slowing of gut transit that is produced by morphine, a preferential A-opioid-receptor agonist. Rats were injected with morphine either centrally or systemically and fed placenta, after which gastrointestinal transit was evaluated. We report here that ingested placenta reversed the slowing of gut transit produced by centrally administered morphine but did not affect the slowing of gut transit produced by systemically administered morphine. These results suggest another likely consequence of placentophagia at parturition in mammalsâreversal of opioid-mediated, pregnancy-based disruption of gastrointestinal functionâas well as an important consideration in opioid-based treatments for pain in humansâenhancement of desirable effects with attenuation of adverse effects
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