The use of section 136 to detain people in police custody

There has been some research into the police use of section 136, the profile of those detained, and the outcome of the assessment across different types of places of safety, but these studies have tended to focus on London. The aim of the study, which is the subject of this article, was to therefore provide a picture of section 136 usage across England and Wales to detain people in police custody. It sought to identify the demographics of those detained, the length and outcome of the detention and the reasons for variation in the use of police custody across different police force areas

2∞2^\infty-Selmer Rank Parities via the Prym Construction

We derive a local formula for the parity of the $2^{\infty}$-Selmer rank of Jacobians of curves of genus $2$ or $3$ with a $K$-rational $2$-torsion point. We give an explicit example to show how this local formula gives rank parity predictions against which the $2$-parity conjecture may be tested. Our results yield applications to the parity conjecture for semistable curves of genus $3$.Comment: 11 page

Arithmetic of Genus Three Curves and Their Jacobians

The Birch–Swinnerton-Dyer Conjecture predicts that, given an abelian variety A over a number field K, its rank, rk(A/K), is equal to the order of vanishing of its L-function L(A/K, s) at s = 1. A consequence of this is the Parity Conjecture; rk(A/K) and the order of vanishing at s=1 of L(A/K, s) are expected to have the same parity. The parity of the latter is given by the root number w(A/K), and so the Parity Conjecture states that (−1)^rk(A/K) = w(A/K). This thesis investigates what can be said about the Parity Conjecture when A is the Jacobian of a curve of genus 3. Part of this requires developing the local theory of non-hyperelliptic genus 3 curves. We introduce a combinatorial object called an octad diagram, which we conjecture to recover the essential data of stable models

Differentiating noise and modulators in artificial neural networks

Research in Computational Neural Networks is currently taking place at many different levels; from coarse-grain symbolic models to fine-grain representations of neurons and cell processes. One feature that the different approaches share, is that they are all in relative infancy. Thus, most research concentrates on gross aspects of neural communication and methods of computational simulation. Recently, some clues have been found which point to more subtle mechanisms underlying the information processing capability of neural 'nodes'. These clues are the improvement in network operation by the injection of random noise; and the neurobiological finding that neuropeptides may exist as slower Signal transmission channels between neurons. This study concerns the difference between random noise injection, and directed, low-level, activity injections which are postulated to be produced by neuromodulators such as neuropeptides. The findings of this study are that random noise does, indeed, enhance the operation of coarse-grain neural models; and that a 'neuropeptidergic' analogue also enhances operation; but to a different extent, and probably through a different mechanism. Further testing of a medium-grain computer model gives some indication of how a neuropeptidergic modulation might affect real neurons, by extending the time-course of the activation of the neuron. This appears to be a similar mechanism to that postulated for the coarse-grain 'neuropeptidergic' simulation model. Given these findings, is it possible that signal transmission in real nervous systems assume these mechanisms? If so, it may be possible that a process of concurrent propagation, through different signal channels, also occurs in real nervous systems, making the nervous system much more complex than current models allow

Investigation in haemodynamic stability during intermittent haemodialysis in the critically ill

No abstract available

An investigation into the effects of commencing haemodialysis in the critically ill

<b>Introduction:</b> We have aimed to describe haemodynamic changes when haemodialysis is instituted in the critically ill. 3 hypotheses are tested: 1)The initial session is associated with cardiovascular instability, 2)The initial session is associated with more cardiovascular instability compared to subsequent sessions, and 3)Looking at unstable sessions alone, there will be a greater proportion of potentially harmful changes in the initial sessions compared to subsequent ones. <b>Methods:</b> Data was collected for 209 patients, identifying 1605 dialysis sessions. Analysis was performed on hourly records, classifying sessions as stable/unstable by a cutoff of >+/-20% change in baseline physiology (HR/MAP). Data from 3 hours prior, and 4 hours after dialysis was included, and average and minimum values derived. 3 time comparisons were made (pre-HD:during, during HD:post, pre-HD:post). Initial sessions were analysed separately from subsequent sessions to derive 2 groups. If a session was identified as being unstable, then the nature of instability was examined by recording whether changes crossed defined physiological ranges. The changes seen in unstable sessions could be described as to their effects: being harmful/potentially harmful, or beneficial/potentially beneficial. <b>Results:</b> Discarding incomplete data, 181 initial and 1382 subsequent sessions were analysed. A session was deemed to be stable if there was no significant change (>+/-20%) in the time-averaged or minimum MAP/HR across time comparisons. By this definition 85/181 initial sessions were unstable (47%, 95% CI SEM 39.8-54.2). Therefore Hypothesis 1 is accepted. This compares to 44% of subsequent sessions (95% CI 41.1-46.3). Comparing these proportions and their respective CI gives a 95% CI for the standard error of the difference of -4% to 10%. Therefore Hypothesis 2 is rejected. In initial sessions there were 92/1020 harmful changes. This gives a proportion of 9.0% (95% CI SEM 7.4-10.9). In the subsequent sessions there were 712/7248 harmful changes. This gives a proportion of 9.8% (95% CI SEM 9.1-10.5). Comparing the two unpaired proportions gives a difference of -0.08% with a 95% CI of the SE of the difference of -2.5 to +1.2. Hypothesis 3 is rejected. Fisher’s exact test gives a result of p=0.68, reinforcing the lack of significant variance. <b>Conclusions:</b> Our results reject the claims that using haemodialysis is an inherently unstable choice of therapy. Although proportionally more of the initial sessions are classed as unstable, the majority of MAP and HR changes are beneficial in nature

“What? That’s for Old People, that.” Home Adaptations, Ageing and Stigmatisation: A Qualitative Inquiry

Older people, even those living with long-term conditions or poor mobility, can be supported to live well at home, through adapting their home to meet changing need. Installing home adaptations, from grab rails to walk in shower rooms, is cost effective, may prevent falls, reduce social isolation and improve self confidence. Despite austerity cuts to public spending, the UK government increased home adaptations’ funding. However, not much is known about older people’s experiences and understanding of acquiring and living with home adaptations and uptake of home adaptations could be improved. Using wearable camera and face to face interview data, this qualitative study explored a diverse group of older people’s retrospective experiences (n = 30). Focus group discussions were also carried out with a wide range of professionals involved in the provision of home adaptations (n = 39). Findings suggest people may delay having adaptations, because of perceived stigmatising associations with decline and vulnerability. As delaying the installation of home adaptations until crisis point is known to reduce their effectiveness, such associations need to be challenged

P416: Red cell distribution width is not a predictor of mortality in acute kidney injury

No abstract available