A survey on fiber nonlinearity compensation for 400 Gbps and beyond optical communication systems

Optical communication systems represent the backbone of modern communication networks. Since their deployment, different fiber technologies have been used to deal with optical fiber impairments such as dispersion-shifted fibers and dispersion-compensation fibers. In recent years, thanks to the introduction of coherent detection based systems, fiber impairments can be mitigated using digital signal processing (DSP) algorithms. Coherent systems are used in the current 100 Gbps wavelength-division multiplexing (WDM) standard technology. They allow the increase of spectral efficiency by using multi-level modulation formats, and are combined with DSP techniques to combat the linear fiber distortions. In addition to linear impairments, the next generation 400 Gbps/1 Tbps WDM systems are also more affected by the fiber nonlinearity due to the Kerr effect. At high input power, the fiber nonlinear effects become more important and their compensation is required to improve the transmission performance. Several approaches have been proposed to deal with the fiber nonlinearity. In this paper, after a brief description of the Kerr-induced nonlinear effects, a survey on the fiber nonlinearity compensation (NLC) techniques is provided. We focus on the well-known NLC techniques and discuss their performance, as well as their implementation and complexity. An extension of the inter-subcarrier nonlinear interference canceler approach is also proposed. A performance evaluation of the well-known NLC techniques and the proposed approach is provided in the context of Nyquist and super-Nyquist superchannel systems.Comment: Accepted in the IEEE Communications Surveys and Tutorial

A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities

[EN] Collagen hydrogels are among the most well-studied platforms for drug delivery and in situ tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility, and similarity to the natural extracellular matrix (ECM). Despite collagen being largely responsible for the tensile properties of native connective tissues, collagen hydrogels have relatively low mechanical properties in the absence of covalent cross-linking. This is particularly problematic when attempting to regenerate stiffer and stronger native tissues such as bone. Furthermore, in contrast to hydrogels based on ECM proteins such as fibronectin, collagen hydrogels do not have any growth factor (GF)-specific binding sites and often cannot sequester physiological (small) amounts of the protein. GF binding and in situ presentation are properties that can aid significantly in the tissue regeneration process by dictating cell fate without causing adverse effects such as malignant tumorigenic tissue growth. To alleviate these issues, researchers have developed several strategies to increase the mechanical properties of collagen hydrogels using physical or chemical modifications. This can expand the applicability of collagen hydrogels to tissues subject to a continuous load. GF delivery has also been explored, mathematically and experimentally, through the development of direct loading, chemical cross-linking, electrostatic interaction, and other carrier systems. This comprehensive article explores the ways in which these parameters, mechanical properties and GF delivery, have been optimized in collagen hydrogel systems and examines their in vitro or in vivo biological effect. This article can, therefore, be a useful tool to streamline future studies in the field, by pointing researchers into the appropriate direction according to their collagen hydrogel design requirements.This work was supported by Medical Research Scotland, EPSRC (through a programme grant EP/P001114/1) and a programme of research funded by the Sir Bobby Charlton Foundation. M.S.S. acknowledges support from a grant from the UK Regenerative Medicine Platform 'Acellular/Smart Materials - 3D Architecture' (MR/R015651/1). The graphical abstract was created using BioRender.com.Sarrigiannidis, S.; Rey, JM.; Dobre, O..; González-García, C.; Dalby, M.; Salmerón Sánchez, M. (2021). A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities. Materials Today Bio. 10(1):1-22. https://doi.org/10.1016/j.mtbio.2021.10009812210

2nd IEEE International Mediterranean Conference on Communications and Networking (IEEE MeditCom 2022) 5-8 September 2022, Athens, Greece

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