Microscopic structure of fundamental excitations in N=Z nuclei

Excitation energies of the $T$=1 states in even-even as well as $T$=0 and $T$=1 states in odd-odd $N$=$Z$ nuclei are calculated within the mean-field approach. It is shown that the underlying structure of these states can be determined in a consistent manner only when both isoscalar and isovector pairing collectivity as well as isospin projection, treated within the iso-cranking approximation, are taken into account. In particular, in odd-odd $N$=$Z$ nuclei, the interplay between quasiparticle excitations (relevant for the case of $T$=0 states) and iso-rotations (relevant for the case of $T$=1 states) explains the near-degeneracy of these fundamental excitations.Comment: 4 pages, 4 figure

Patient-Powered Research Networks of the Autoimmune Research Collaborative: Rationale, Capacity, and Future Directions

Patient-Powered Research Networks (PPRNs) are US-based registry infrastructures co-created by advocacy groups, patient research partners, academic investigators, and other healthcare stakeholders. Patient-Powered Research Networks collect information directly from patients to conduct and disseminate the results of patient-centered/powered research that helps patients make more informed decisions about their healthcare. Patient-Powered Research Networks gather and utilize real-world data and patient-reported outcomes to conduct comparative effectiveness, safety, and other research, and leverage the Internet to accomplish this effectively and efficiently. Four PPRNs focused on autoimmune and immune-mediated conditions formed the Autoimmune Research Collaborative: ArthritisPower (rheumatoid arthritis, spondyloarthritis, and other rheumatic and musculoskeletal diseases), IBD Partners (inflammatory bowel disease), iConquerMS (multiple sclerosis), and the Vasculitis PPRN (vasculitis). The Autoimmune Research Collaborative aims to inform the healthcare decision making of patients, care partners, and other stakeholders, such as clinicians, regulators, and payers. Illustrated by practical applications from the Autoimmune Research Collaborative and its constituent PPRNs, this article discusses the shared capacities and challenges of the PPRN model, and the opportunities presented by collaborating across autoimmune conditions to design, conduct, and disseminate patient-centered outcomes research

A schematic model for QCD at finite temperature

The simplest version of a class of toy models for QCD is presented. It is a Lipkin-type model, for the quark-antiquark sector, and, for the gluon sector, gluon pairs with spin zero are treated as elementary bosons. The model restricts to mesons with spin zero and to few baryonic states. The corresponding energy spectrum is discussed. We show that ground state correlations are essential to describe physical properties of the spectrum at low energies. Phase transitions are described in an effective manner, by using coherent states. The appearance of a Goldstone boson for large values of the interaction strength is discussed, as related to a collective state. The formalism is extended to consider finite temperatures. The partition function is calculated, in an approximate way, showing the convenience of the use of coherent states. The energy density, heat capacity and transitions from the hadronic phase to the quark-gluon plasma are calculated.Comment: 33 pages, 11 figure

A schematic model for QCD I: Low energy meson states

A simple model for QCD is presented, which is able to reproduce the meson spectrum at low energy. The model is a Lipkin type model for quarks coupled to gluons. The basic building blocks are pairs of quark-antiquarks coupled to a definite flavor and spin. These pairs are coupled to pairs of gluons with spin zero. The multiplicity problem, which dictates that a given experimental state can be described in various manners, is removed when a particle-mixing interaction is turned on. In this first paper of a series we concentrates on the discussion of meson states at low energy, the so-called zero temperature limit of the theory. The treatment of baryonic states is indicated, also.Comment: 29 pages, 6 figures. submitted to Phys. Rev.

Polystyrene-coated micropallets for culture and separation of primary muscle cells

Despite identification of a large number of adult stem cell types, current primary cell isolation and identification techniques yield heterogeneous samples, making detailed biological studies challenging. To identify subsets of isolated cells, technologies capable of simultaneous cell culture and cloning are necessary. Micropallet arrays, a new cloning platform for adherent cell types, hold great potential. However, the microstructures composing these arrays are fabricated from an epoxy photoresist 1002F, a growth surface unsuitable for many cell types. Optimization of the microstructures’ surface properties was conducted for the culture of satellite cells, primary muscle cells for which improved cell isolation techniques are desired. A variety of surface materials were screened for satellite cell adhesion and proliferation and compared to their optimal substrate, gelatin-coated Petri dishes. A 1-μm thick, polystyrene copolymer was applied to the microstructures by contact-printing. A negatively charged copolymer of 5% acrylic acid in 95% styrene was found to be equivalent to the control Petri dishes for cell adhesion and proliferation. Cells cultured on control dishes and optimal copolymer-coated surfaces maintained an undifferentiated state and showed similar mRNA expression for two genes indicative of cell differentiation during a standard differentiation protocol. Experiments using additional contact-printed layers of extracellular matrix proteins collagen and gelatin showed no further improvements. This micropallet coating strategy is readily adaptable to optimize the array surface for other types of primary cells

Use of small specimen creep data in component life management: a review

Small specimen creep testing techniques are novel mechanical test techniques that have been developed over the past 25 years. They mainly include the sub-size uniaxial test, the small punch creep test, the impression creep test, the small ring creep test and the two-bar creep test. This paper outlines the current methods in practice for data interpretation as well as the state-of-the-art procedures for conducting the tests. Case studies for the use of impression creep testing and material strength ranking of creep resistant steels are reviewed along with the requirement for the standardisation of the impression creep test method. A database of small specimen creep testing is required to prove the validity of the tests

The formation of human populations in South and Central Asia

By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization’s decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages