Top-bottom mass hierarchy, s−μs-\mu puzzle and gauge coupling unification with split multiplets

A supersymmetric 5D SU(5) grand unification is considered. The SU(5) is broken down to $G_{SM}=SU(3)\times SU(2)\times U(1)$ by the $Z_2\times Z_2'$ assignment of the bulk field(s). The matter fields are located at the fixed point(s). In the bulk, a Higgs multiplet $\bar 5_H$(containing the bottom doublet $H_1$) and the SU(5) gauge multiplet are located. At one fixed point, $H_2$(the top doublet) and the standard model matter multiplets are presented. Because of the difference of the locations of $H_1$ and $H_2$, one can obtain a hierarchy between top and bottom Yukawa couplings. We also present a possibility to understand the $s-\mu$ mass puzzle in this framework of the split multiplet.Comment: LaTeX file of 17 pages including 3 eps figures. A note is added and typo errors corrected. To appear in Euro. Phys. J.

Taurine reduces ER stress in C. elegans

<p>Abstract</p> <p>Background</p> <p>ER stress is a strong indicator of whether or not a cell is undergoing physiological stress. C. elegans is a practical system of characterizing the effect of ER stress at the <it>in vivo</it> or organismal level.</p> <p>Methods</p> <p>This study characterized taurine’s anti-ER stress potential employing western blotting on ER stress markers and assays of motility, lifespan comparison, and fecundity measurement.</p> <p>Results</p> <p>When treated with tunicamycin, C. elegans showed the typical ER stress symptoms. It showed a higher expression of hsp-70 and skn-1 than the non-treated control. Survivorship significantly decreased under tunicamycin treatment, and the offspring number also decreased. During the synchronized culture under ER stress conditions, the C. elegans showed early signs of aging especially between L3 and L4 within their life span, along with lowered motility. The worms, however, showed a positive response to the taurine treatment under ER stress conditions.</p> <p>Conclusions</p> <p>When C. elegans were treated with taurine before or after the tunicamycin treatment, they showed a less severe level of ER stress, including an enhanced survivorship, increased motility, and augmented fecundity. Taken together, these results strongly indicate that taurine works positively to cope with ER stress from the organismal perspective.</p

Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders

Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension. Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed. Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs to the nuclear receptor superfamily, has many beneficial clinical effects. PPAR directly modulates gene expression by binding to a specific ligand. All PPAR subtypes (α, γ, and σ) are involved in glucose metabolism, lipid metabolism, and energy balance. PPAR agonists play an important role in therapeutic aspects of metabolic disorders. However, undesired effects of the existing PPAR agonists have been reported. A great deal of recent research has focused on the discovery of new PPAR modulators with more beneficial effects and more safety without producing undesired side effects. Herein, we briefly review the roles of PPAR in metabolic disorders, the effects of PPAR modulators in metabolic disorders, and the technologies with which to discover new PPAR modulators

The expression and cellular localization of phospholipase D isozymes in the developing mouse testis

To examine the involvement of phospholipase D (PLD) isozymes in postnatal testis development, the expression of PLD1 and PLD2 was examined in the mouse testis at postnatal weeks 1, 2, 4, and 8 using Western blot analysis and immunohistochemistry. The expression of both PLD1 and PLD2 increased gradually with development from postnatal week 1 to 8. Immunohistochemically, PLD immunoreactivity was detected in some germ cells in the testis and interstitial Leydig cells at postnatal week 1. PLD was mainly detected in the spermatocytes and residual bodies of spermatids in the testis after 8 weeks after birth. The intense immunostaining of PLD in Leydig cells remained unchanged by postnatal week 8. These findings suggest that PLD isozymes are involved in the spermatogenesis of the mouse testis

Improving Exploration And Exploitation Capability Of Harmony Search Algorithm

Harmony Search (HS) is a meta-heuristic algorithm which was first introduced in 2001 and it became a widely used optimization algorithm in various areas in engineering application as well as in water resources planning and management. However, as most meta-heuristic algorithms are, the HS shows a good performance in global search but not as good in local search. This study aims the improvement of both exploration and exploitation capability of the algorithm. The mission has been carried out by changing algorithm operators or parameters in the search process. Several types of Improved Harmony Search (IHS) have been successfully developed resulting better exploiting (local) search. Alternative way is to utilize the superior local search of other models or algorithms. The combined, so called hybrid algorithms can significantly supplement the weak local search aspect of the original HS. A newly developed hybrid algorithm, Smallest Small World Cellular Harmony Search (SSWCHS), is developed and proposed shorter characteristic path length and higher clustering coefficient, resulting good exploration and exploitation efficiency. Application to benchmark functions and design of pipe networks proves the superior performance of the newly developed hybrid algorithm