5. Ölüm yıldönümünde:Kemal Tahir, romanı Türkiye'nin tarihsel gerçeği ile yoğurup Türk romanını yaratma savındadır

Taha Toros Arşivi, Dosya No: 133-Kemal Tahir ve Yorgun SavaşçıUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

Crowdsourced mapping of unexplored target space of kinase inhibitors

Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexplored compound-kinase interactions for novel and potent activities. Here, we carry out a crowdsourced benchmarking of predictive algorithms for kinase inhibitor potencies across multiple kinase families tested on unpublished bioactivity data. We find the top-performing predictions are based on various models, including kernel learning, gradient boosting and deep learning, and their ensemble leads to a predictive accuracy exceeding that of single-dose kinase activity assays. We design experiments based on the model predictions and identify unexpected activities even for under-studied kinases, thereby accelerating experimental mapping efforts. The open-source prediction algorithms together with the bioactivities between 95 compounds and 295 kinases provide a resource for benchmarking prediction algorithms and for extending the druggable kinome. The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts

Bütün mümkünlerin kıyısında

Taha Toros Arşivi, Dosya No: 135-Oktay Rifat-Samih HorozcuUnutma İstanbul projesi İstanbul Kalkınma Ajansı'nın 2016 yılı "Yenilikçi ve Yaratıcı İstanbul Mali Destek Programı" kapsamında desteklenmiştir. Proje No: TR10/16/YNY/010

Balıkçı günlüğü

Taha Toros Arşivi, Dosya Adı: Ahmet Cevat Paşa-Cevat Şakir Kabaağaçl

Özel bölüm:Orhan Veli (1914 - 14 Kasım 1950):"Yaprak" döneminde Orhan Veli

Taha Toros Arşivi, Dosya No: 39-Orhan Veli-Adnan Veli Kanıkİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN/0033