Assessment of Carotid Intima-media Thickness in COVID-19 Survivors

Background and Aim:Coronavirus disease-2019 (COVID-19) infection is associated with cardiovascular diseases in the acute and chronic stages. One of the most common causes of death worldwide is atherosclerosis. Carotid intima media thickness is a method used in the early diagnosis and follow-up of atherosclerosis. This study describes endothelial dysfunction and the risk for pre-atherosclerosis using carotid intima-media thickness (CIMT) measurements in patients with a history of COVID-19 infection.Materials and Methods:This was a prospective case-control study of 121 patients with 121 COVID-19 infections and 40 healthy controls. Groups were compared according to demographic characteristics, body mass index (BMI), and carotid intima-media thickness. Data obtained were analyzed using SPSS version 22.0.Results:There was no statistically significant difference between the groups in terms of age, gender, BMI, and blood pressure values. The CIMT value of the group with COVID-19 infection was significantly higher than the control group (P = 0.003).Conclusion:The findings of this study show that CIMT, which is an indicator of early atherosclerosis, was increased in patients with COVID-19

Determining the secondary school teachers’ self-efficacy beliefs about teaching professionOrtaokullarda görev yapan öğretmenlerin öğretmenlik mesleğine yönelik öz yeterlik algilarinin incelenmesi

Self-efficacy refers to beliefs about one’s capabilities to learn or perform behaviors at designated levels (Bandura, 1997). The main aim of this study is to determine the self-efficacy beliefs of teachers about teaching profession. The research was designed based on a descriptive survey method. The research group comprised 217 secondary school teachers working in 22 schools in Gaziantep city center in Turkey. The data were collected using the Teachers’ Sense of Efficacy Scale originally developed by Tschannen-Moran ve Woolfolk Hoy (2001) and adapted to Turkish by Çapa, Çakıroğlu, Sarıkaya (2005). The data were analyzed using basic descriptive statistics (arithmetic means and standard deviations), independent samples t test and one way Anova analysis.As a result of the study it was concluded that participating secondary school teachers had favorable beliefs of self-efficacy in terms of teaching profession. We can conclude that gender is not effective according to the context of the self-efficacy. Subjects taught are not related with self-efficacy in this study. Finally this study showed that reward and punishment is very important for the self-efficacy beliefs of the secondary teachers. Because self-efficacy influences academic motivation some activities can be done to increase the self-efficacy beliefs of the teachers by providing different reward system. ÖzetÖz-yeterlik bireylerin herhangi bir performansa yönelik kendileri hakkında algıları şeklinde tanımlanmaktadır. Öğretmenlerin mesleklerine ilişkin öz-yeterlik algıları öğretimin kalitesini doğrudan etkileyen faktörlerden birisidir. Ortaokul öğretmenlerinin öğretmenlik mesleğine yönelik öz yeterlik algılarının araştırıldığı bu çalışma betimsel bir tarama çalışmasıdır. Araştırma 2013–2014 eğitim-öğretim yılında Gaziantep İl Milli Eğitim Müdürlüğüne bağlı olan 22 ortaokulda görev yapan 217 öğretmenle gerçekleştirilmiştir. Araştırmada veriler orjinali Tschannen-Moran ve Woolfolk Hoy (2001) tarafından geliştirilen ve Türkçeye adaptasyonu Çapa, Çakıroğlu, Sarıkaya (2005) tarafından yapılan  “Öğretmen Öz-yeterlik” ölçeği kullanılmıştır. Veriler SPSS programı ile, frekans, yüzde, varyans analizi, bağımsız gruplar t-testi gibi tekniklerle analiz edilmiştir. Araştırmadan elde sonuçlara göre öğretmenlerin mesleklerine yönelik öz-yeterlik algıları yüksektir, cinsiyete, branşa ve sınıf mevcuduna göre değişmemektedir. Ancak öğretmenlerin öz-yeterlik algıları almış oldukları disiplin cezalara ve ödüllere göre değişiklik göstermektedir. Araştırmadan elde edilen sonuçlar ışığında öğretmenlerin öz-yeterliklerini artırıcı ödül uygulamaları ve öz-yeterliğe etkisi zayıf ceza uygulamalarının geliştirilmesi önerilmektedir

Yeni Fosfonik Asit Türevi Organokatalizörlerin Geliştirilmesi ve Organik Bileşiklerin Enantiseçici Sentezinde Uygulamaları

TÜBİTAK KBAG Proje15.06.2017Organokatalizörler asimetrik sentez çalışan Organik Kimyacıların yaklaşık son yirmi yıldıryoğun olarak çalıştıkları konudur. Metal içermedikleri ve tepkime koşullarının metalkatalizörlere göre daha kolay olması organokatalizörleri daha çevreci kılmaktadır. Literatürdebir çok organokatalizör sentezlenip kullanılmış olmakla birlikte bu katalizörler belirlitepkimelerle sınırlı kalmıştır. O nedenle sürekli yeni katalizörler geliştirilip farklı tepkimelerdedenenmektedir. Küçük organik bileşikler olarak bilinen bu katalizörler içerisinde en çokbilinenlere örnek olarak tiyoüre ve fosforik asit bileşikleri verilebilir. Grubumuz aziridinilfosfonatlar üzerine çalışmalar yapmış ve bu bileşiklerin rasemik formlarını sentezleyerekbiyolojik aktivitelerini çalışmıştır. Bu proje kapsamında kiral aziridinil fosfonatlar sentezlenerekbiyolojik aktiviteleri ölçülmüştür. Sonrasında bu bileşikler hidroliz edilerek fosfonik asittürevlerine dönüştürülmüş ve organokatalizör etkileri araştırılmıştır. Organokatalitik olarakazometin ylidlerin 1,3-dipolar halkasal katılma tepkimesiyle pirolidin sentezi, iminlereorganokatalitik indol katılması tepkimesi, iminlere organokatalitik N-metilpirol katılmasıtepkimesi, indol bileşiğinin nitrostirene organokatalitik enenatioseçici katılması tepkimeleriçalışılmıştır. Bu tepkimelerin her biri farklı koşullarda denenmiş ancak literatürde ilk kezsentezlenen aziridinil fosfonik asitlerin organokatalitik olarak denemesi yapılan tepkimelerdeçok düşük enantioseçicilik sağladıkları görülmüştür.New types of phosphonic acids were synthesized for the first time in this project and theirorganocatalytic effect on different organic reactions were investigated. For the synthesis ofphosphonic acids vinil phosphonate was brominated first then reacted with chiral amines.This reaction is known as modified Gabriel-Cromwell reaction. From this reaction aziridinilphosphonates were obtained as a mixture of diastereomers which were purified andseparated by flash column chromatography. Antibacterial and antifungal effects of aziridinylphosphonates are known in the literature therefore antibacterial and antifungal effect of thesecompounds were also investigated first. Two of the aziridinil phosphonates showedconsiderable effects. The synthesis of aziridinil phosphonic acids were achieved by thehydrolysis of aziridinyl phosphonates under basic conditions then by protonation with a resinin acidic form. Synthesized phosphonic acids were tested as organocatalysts for differentorganic reactions. Although the phosphonic acids increased the rate of the reactions, theyshowed very low effect on the enantioselectivity

Aesthetic full-mouth oral rehabilitation of a young adult with amelogenesis imperfecta: a clinical report

Amelogenesis imperfecta (AI) encompasses a complicated group of hereditary conditions that cause developmental alterations in the structure of the enamel in the absence of a systemic disorder. AI primarily affects the quality and/or quantity of dental enamel, and it may affect all or only some of the teeth in the primary and/or permanent dentition. Treatment of a patient with amelogenesis imperfecta (AI) presents a real problem from both functional and esthetic points of view. An esthetic result also will result in an improvement in the patient’s quality of life. This clinical report illustrates the oral rehabilitation of a 23-year-old woman diagnosed with hypomature type of AI. The aim of treatment was to both restore esthetics and improve masticatory function. Aesthetic and functional expectations were met zircon- ceramic restorations

Fistula Campaigns-Are They of Any Benefit?

Objective Evaluation of the problems encountered during a voluntarily fistula campaign in a regional hospital of Niger (Africa) Materials and Methods Women underwent basic gynecological examination, methylene blue testing, and/or direct cystoscopy as necessary According to their clinical condition, women were informed and surgical options offered as appropriate Operations were performed under spinal or epidural anesthesia Immediate postoperative outcomes were followed during the stay of the surgical team in the country Results A total of 62 women were examined and 11 had causes of incontinence other than obstetric fistula In 9 8% of the women, severe local infection precluding any surgical intervention was evident In 58 8% of patients, the trigonal region and/or urethra were irreversibly damaged A proportion of patients (9 8%) with large lesions and intact urethra that were offered vaginal layered closure refused the intervention Of the women that were operated on (21 6%), six underwent vaginal layered closure with Martius fat flap and five women underwent a combined abdomino vaginal approach Conclusion It is extremely difficult to meet the needs of this global problem with short term programs and volunteers Directing these efforts to specialist fistula centers and creating reliable scientific evidence should be the main goal [Taiwan J Obstet Gynecol 2010,49(3) 291-296

Farklı Laboratuvarlarca Dökümü Yapılmış Tek Parça Döküm Parsiyel Protezlerde Kullanılan Metal Alaşımların Sitotoksisite Yönünden Değerlendirilmesi

Amaç: Bu araştırmanın amacı farklı laboratuvarlarca dökümü yapılmış tek parça döküm parsiyel protezlerde kullanılan metal alaşımların değerlendirilmesidir.sitotoksisite yönünden Gereç ve Yöntem: Sivas’ta faaliyet gösteren 4 farklı laboratuvardan, kumlama ve kumlama+cila işlemi uygulanmış 1 mm çapında,1.5 mm kalınlıkta disk şeklindeki metal örnekler elde edildi. Hazırlanan metal örnekler etilen oksit gazıyla sterilize edildi ve L929 fibroblast hücre serisi kullanlarak elde edilen kültüre yerleştirildi. Agar overley testi kullanılarak sitotoksisitenin belirlenmesinde ISO 2009 yılı 10993-5 numaralı protokolü takip edildi.Bulgular: Hücrelerin lizis miktarna göre yapılan laboratuvardan 3 tanesinden elde edilen örnekler sitotoksik bulunmamışken, 1 tanesinden elde edilen bulunmuştur. Ayrıca çalışmamızda tüm gruplarda kumlama ve kumlama+cila arasında sitotoksite açısından fark bulunamamıştı

Expectations of pregnant women for antenatal care services and factors affecting anxiety severity during the COVID-19 pandemic

Objectives: We aimed to evaluate the difficulties pregnant women encountered while receiving health care, their demands for antenatal care, and their mental state during the COVID-19 pandemic. Material and methods: A total of 447 pregnant women were included in this cross-sectional study. The data were collected through a face-to-face questionnaire, which assessed participants’ demographic, individual, and obstetric characteristics, their opinions regarding the COVID-19 pandemic, expectations from their antenatal care services, and their Beck Anxiety Inventory (BAI) scores. Results: During the COVID-19 pandemic, it was determined that 17.2% of the pregnant women participating in our study could not go to antenatal follow-ups and almost half (45.9%) demanded that their follow-ups be reduced due to the risk of coronavirus transmission. The BAI scores were found to be significantly higher in participants with low-income levels, chronic diseases, those in the third trimester, those with high-risk pregnancy either previous or current, and those who got pregnant unintentionally. Young age, unintentional conception, advanced pregnancy week, previous high-risk pregnancy, and failure to receive regular antenatal care were independent variables that predicted moderate-severe anxiety in logistic regression analysis. Conclusions: In order to minimize the adverse effects of the COVID-19 pandemic on the mental health of pregnant women, it is important to develop support programs that contribute to the well-being of the mother and fetus by recognizing the pregnant women at risk in the antenatal period