Elliptic flow of charged particles at midrapidity relative to the spectator plane in Pb–Pb and Xe–Xe collisions

Measurements of the elliptic flow coefficient relative to the collision plane defined by the spectator neutrons v2{ SP} in collisions of Pb ions at center-of-mass energy per nucleon–nucleon pair √ 2.76 TeV and Xe ions at √ sNN = sNN =5.44 TeV are reported. The results are presented for charged particles produced at midrapidity as a function of centrality and transverse momentum for the 5–70% and 0.2–6 GeV/c ranges, respectively. The ratio between v2{ SP} and the elliptic flow coefficient relative to the participant plane v2{4}, estimated using four-particle correlations, deviates by up to 20% from unity depending on centrality. This observation differs strongly from the magnitude of the corresponding eccentricity ratios predicted by the TRENTo and the elliptic power models of initial state fluctuations that are tuned to describe the participant plane anisotropies. The differences can be interpreted as a decorrelation of the neutron spectator plane and the reaction plane because of fragmentation of the remnants from the colliding nuclei, which points to an incompleteness of current models describing the initial state fluctuations. A significant transverse momentum dependence of the ratio v2{ SP}/v2{4} is observed in all but the most central collisions, which may help to understand whether momentum anisotropies at low and intermediate transverse momentum have a common origin in initial state f luctuations. The ratios of v2{ SP} and v2{4} to the corresponding initial state eccentricities for Xe–Xe and Pb–Pb collisions at similar initial entropy density show a difference of (7.0 ±0.9)%with an additional variation of +1.8% when including RHIC data in the TRENTo parameter extraction. These observations provide new experimental constraints for viscous effects in the hydrodynamic modeling of the expanding quark–gluon plasma produced in heavy-ion collisions at the LHC

First measurement of Ωc0 production in pp collisions at s=13 TeV

The inclusive production of the charm–strange baryon 0 c is measured for the first time via its hadronic √ decay into −π+ at midrapidity (|y| <0.5) in proton–proton (pp) collisions at the centre-of-mass energy s =13 TeV with the ALICE detector at the LHC. The transverse momentum (pT) differential cross section multiplied by the branching ratio is presented in the interval 2 < pT < 12 GeV/c. The pT dependence of the 0 c-baryon production relative to the prompt D0-meson and to the prompt 0 c-baryon production is compared to various models that take different hadronisation mechanisms into consideration. In the measured pT interval, the ratio of the pT-integrated cross sections of 0 c and prompt + c baryons multiplied by the −π+ branching ratio is found to be larger by a factor of about 20 with a significance of about 4σ when compared to e+e− collisions

Промышленная политика России как драйвер экономического роста в условиях "новой реальности"

Importance Notwithstanding the recent achievements, the contemporary industrial sector of Russia cannot become the platform for further breakthrough. While the leading economies reach a new technological level, Russia has to deal with external challenges, thus lagging behind the developed countries. Objectives The research attempts to determine structural characteristics of the economy, which may become points of growth in competitiveness. We also analyze the consistency of industrial policy and other types of governmental regulation. The article outlines our suggestions for making the industrial policy more efficient. Methods The research draws upon data from the UN, OECD, World Economic Forum and applies the expert assessment method, comparative analysis and other comparative techniques. Results The industrial policy tools are found to be susceptible to the competence level of governmental authorities, implying corruption risks and undermine the competitive market principles. They can be substituted with the so called open access institutions. However, economies in transit do not have perfect institutions. So, it is difficult to succeed in the outstripping development without governmental regulation procedures in place. Comparative advantages are proved to be a channel to the international division of labor, focusing on the outstripping growth in high-tech production. Thus, we consider the issue of special credit issue as a source of finance for the knowledge-intensive sector since borrowing of knowledge and technologies may push the country into a long-standing scientific and technological backwardness. Conclusions We assume that Russia will be able to attain the Industry 4.0 level by constructively breaking many global value chains, thus opening opportunities for Russia's industrial sector.Предмет. Современное состояние промышленности России, несмотря на достижения последних лет, не может служить основой для намеченного «прорыва». Когда в ведущих экономиках реализуются программы перехода на новый технологический уровень, «новая реальность» для России усугубляется внешними вызовами, и если медлить, то отставание от развитых стран станет непреодолимым. Цели. Определение структурных параметров экономики, которые могут стать точками роста конкурентоспособности, анализ соотнесения ПП и других видов госрегулирования. Предложения, направленные на повышение эффективности ПП. Методология. Использовались данные Росстата, ООН, ОЭСР, ВЭФ в Давосе, применялись метод экспертных оценок, сравнительный анализ, другие компаративные методики. Результаты. Установлено, что инструменты ПП чувствительны к уровню компетентности государственного менеджмента, содержат коррупционные риски и нарушают принципы конкурентного рынка. Их альтернатива - так называемые институты открытого доступа. Однако институты в транзитивных экономиках несовершенны, и без процедур госрегулирования сложно обеспечить успех догоняющего развития. Установлено, что интегрироваться в международное разделение труда надо вновь создаваемыми «сравнительными преимуществами» с опорой на опережающий рост высокотехнологичных производств. В связи с этим рассмотрен вопрос о «целевой кредитной эмиссии» как источнике финансирования наукоемкого сектора, поскольку практика «заимствования» знаний и технологий опасна консервацией научно-технической отсталости. Выводы. Высказана гипотеза, что переход на уровень «Промышленность 4.0» будет сопровождаться «созидательным разрушением» многих глобальных цепочек стоимости, что создает «окно возможностей» для индустриального комплекса России

Intraovarian autoplasmotherapy in patients with diminished ovarian reserve

Objective. To evaluate the efficacy of Intraovarian autoplasmotherapy (platelet-rich plasma/PRP) in the activation of ovarian function in patients with diminished ovarian reserve and “poor” response in the in vitro fertilization (IVF) cycles, as well as its influence on the quality of life. Patients and methods. A total of 120 patients with diminished ovarian reserve and a history of IVF cycle failure who refused to use donor oocytes were included in the study. All patients underwent intraovarian PRP therapy based on the proprietary technology. The quality of life, the ovarian function, and the results of the embryo stage in the IVF cycle were monitored for 6 months. Results. The conducted study demonstrates a positive effect of intraovarian PRP therapy on the functional state of the ovaries and on the results of the embryo stage in IVF in the cohort of patients with diminished ovarian reserve and “poor” response in previous unsuccessful IVF cycles. The findings also indicate changes in the quality of life, an improvement in sexual function, and positive dynamics in the emotional state. Conclusion. Intraovarian PRP therapy allows patients with infertility and diminished ovarian reserve to avoid using donor oocytes and to obtain their own genetic material. This technology has a positive effect on the quality of life, having a certain anti-age effect in all groups of examined women, the duration of which has yet to be clarified. © 2021, Dynasty Publishing House. All rights reserved

Worldview orientations of religious literature as an agent of socialization in the modern society

The article explores the concept and the essence of religious socialization as well as the role of religious literature in the socialization of individuals. The authors suggest a classification of religious texts and give recommendations regarding usage of religious literature as an agent of socialization in the modern society. The relevance of this topic lies in the fact that local cultures might lose their identities when borrowing the features typical for other world cultures. As a result, the process of individual socialization often includes the adoption of immoral and anti-spiritual ideas. However, religious literature, as one of the agents of socialization, can exercise a positive influence on this process. Scientific novelty of the paper consists in the analysis of factors involved in religious socialization and determination of the function of religious literature in this process. © 2019, Ecozone, OAIMDD. All rights reserved

PHRASEOLOGY AND INSTITUTIONAL DISCOURSE: ANGELA MERKEL

The article presents the linguosemiotic approach to the study of phraseological units used by an institutional language personality. It enlists theoretical prerequisites for modeling this type of personality. The explicit meaning of an utterance is regarded as the key element highlighting features of phraseological communication. Other levels are considered during the contrastive description of institutional text and complement the essential parameters conveyed by the structure of ethnocultural code that underlies the construction of statements in national language. The language personality of a politician, in particular Angela Merkel, is considered as an active mechanism for the functioning of institutional discourse. There are certain prospects for analyzing institutional communication with due regard to the extralinguistic factors associated with the communicative competence of a recipient of institutional messages

CURRENT POSSIBILITIES OF NONHORMONAL OVARIAN FUNCTION ACTIVATION WITH LOW OVARIAN RESERVE

Patients with low ovarian reserve occupy a significant place in the pattern of an infertile marriage. Ovarian reserve is a clinical phenomenon caused by age, genetics, autoimmune mechanisms, and environmental factors. This term is used to describe the reproductive potential and to predict a response to controlled ovulation stimulation in assisted reproductive technology programs. According to a variety of data, the prevalence of low ovarian reserve varies from 5.6 to 35.1%. To date, little is known about the causes of diminished ovarian reserve and its risk factors except the iatrogenic factors associated with surgical intervention. From the clinical point of view, the low ovarian reserve group includes female patients with a poor ovarian response, those with premature ovarian failure, and late reproductive-aged women. Current strategies for controlled ovarian stimulation focus on growing follicles; in this case, dormant primordial follicles cannot be activated by the currently known stimulation protocols. The most successful outcome in patients with a poor response or ovarian insufficiency is pregnancy achieved using donor oocytes, but a large majority of the women think badly of these programs and are looking for alternative solutions. The literature review presents an update on the possibilities, features, and side effects of technologies for nonhormonal ovarian function activation with low ovarian reserve: autologous intraovarian platelet rich plasma (PRP) therapy, stem cell injections, and surgical ovarian activation. Conclusion: Heterogeneity in study designs and data analysis does not yet allow the effectiveness of the technologies under consideration to be evaluated. For none of them, the exact mechanisms of action are still unknown. However, in our opinion, intraovarian PRP injection is the safest and most effective therapy. At the same time, the features of the technology and its effectiveness in various patient cohorts require further careful study. © A group of authors, 2022

Экспериментальное исследование влияния ионизирующего излучения на минерализацию эмали различных функциональных групп зубов, как возможный этиологический фактор возникновения лучевого кариеса

Targets and goals. Using the method of Raman spectroscopy to study the mineralization of various anatomical and topographic zones of teeth of different functional groups before and after exposure to radiation factor at a dose of 2-70 Gy, to identify the degree of direct exposure to ionizing radiation on the tooth enamel. Methods. In this preclinical in vitro study on 40 model test objects of teeth removed according to clinical indications (incisors, premolars, molars) irradiated with an X-ray biological apparatus LNK-268 (RAP-100-10), voltage 70 kV, beam current 8 mA , dose rate of 22.7 Gy/min. The teeth were irradiated with a dose of 2 Gy, 20 Gy, 70 Gy and 110 Gy. Using the APK InSpectr M with a probe radiation wavelength of 532 nm, test objects (tooth enamel) measured the mineralization of the tooth enamel, using the intensity index of the Raman line hydroxyl appatite (x=963 cm-1) in relative units before and after irradiation of the teeth. At the same time was made the collection and processing of the information received. The measurements were carried out perpendicular to the tooth surface in the contact-stable position of the object (tooth) to the radiation source. To quantify the intensity of Raman radiation (in relative units), indicators at the maximum and minimum of the power of its Raman line and indicators of fluorescence intensity (M cf. relative) were measured as a test to assess the hygienic condition of the tooth surface). the difference obtained in the Raman line of hydroxy lappatite (relative units) was taken as the intensity of Raman for enamel, dentin and cement of the studied teeth (M cf.). Results. As a result, a qualitative and quantitative analysis of the content and distribution of hydroxyapatite in the structures of hard dental tissues (enamel, dentin, cement) was carried out before and after exposure to radiation factor in a dose of 2-110 Gr. There were no significant differences in the mineralization of hard dental tissues, regardless of the radiation dose. Conclusion. The high sensitivity and rapidity of the method was revealed, the possibility of quantitative processing of the results of the study online, which allows recommending it to assess the degree of mineralization/demineralization of the tooth, the effectiveness of remineralizing drugs and methods for their use, including for patients receiving radiation therapy for malignant tumors of the maxillofacial region.Цели и задачи. Методом Рамановской спектроскопии исследовать минерализацию различных анатомо-топографических зон зубов различных функциональных групп до и после воздействия лучевого фактора в дозе 2-70 Гр, выявить степень прямого воздействия ионизирующего излучения на эмаль зубов. Методы. В настоящем доклиническом исследовании in vitro 40 модельных тест-объектов зубов, удаленных по клиническим показаниям (резцы, премоляры, моляры), облучали на биологической рентгеновской установке ЛНК-268 (РАП-100-10; напряжение 70 кВ, ток пучка 8 мА, мощность дозы 22,7 Гр/мин). Облучение проводили в дозах 2, 20, 70 и 110 Гр. С помощью АПК «ИнСпектр М» с длиной волны зондирующего излучения 532 нм измеряли минерализацию эмали до и после облучения по показателю интенсивности Рамановской линии гидроксилапатита (х=963 см-1) в относительных единицах. Измерения проводили перпендикулярно поверхности зуба в контактно-стабильном положении зуба к источнику излучения. Для количественной оценки интенсивности Рамановского излучения (в отн. ед.) измеряли показатели в максимуме и минимуме мощности его Рамановской линии и показатели интенсивности флюоресценции (М ср. в отн.ед) как тест оценки гигиенического состояния поверхности зуба (по Александрову М.Т., 2008). Полученную разницу по Рамановской линии гидроксилапатита (отн. ед.) принимали за интенсивность Рамана для эмали, дентина и цемента исследуемых зубов (М ср.). Результаты. В исследовании проведен качественный и количественный анализ содержания и распределения гидроксилапатита в структурах твердых тканей зубов (эмаль, дентин, цемент) до и после воздействия лучевого фактора. Не выявлено существенных различий минерализации твердых тканей зубов независимо от дозы облучения. Заключение. Выявлена высокая чувствительность и экспрессность метода, возможность количественной обработки в режиме «онлайн» результатов исследования, что позволяет рекомендовать его для оценки степени минерализации/деминерализации зуба, эффективности реминерализирующих препаратов и методов их применения, в том числе для пациентов, получающих лучевую терапию по поводу злокачественных новообразований челюстно-лицевой области