Supplementary Feeding of Grazing Dairy Cows

The objective of this paper was to consider the effect of supplementary feeding of grazing dairy cows on dry matter intake (DMI), milk production and milk composition. Accurate estimations of total DMI and pasture DMI are important to the management of dairy grazing systems. The intakes of dry matter (DM) and net energy-NEL are lower on the pasture-only diet compared with cows supplementary fed with concentrate. Many pasture factors affect DMI, including pregrazing pasture mass and pasture allowance. Milk production of high producing grazing dairy cows in early lactation increases linearly as the amount of concentrate increases to 10 kg DM/day with a milk response of 1 kg milk/kg concentrate. In late lactation, increases are with a lower milk response per kilogram of supplemented concentrate. With the amount of concentrate supplementation, milk fat and protein yield increase while milk fat percentage decreases. Supplementation with rumen undegradable protein (RUP) is important for meeting requirements of grazing dairy cows, because the pasture has high ruminal crude protein (CP) degradability. Corn silage supplementation to grazing cows may increase milk production if pasture offered is restricted, but if pasture is offered ad libitum milk production does not change or can decrease. Supplementation of ruminally inert fat could have positive effect on milk production with concentrate supplemented at a lower rate

Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of wistar rats.

Summary Clinical reports suggest close interactions between stressors, particularly those of long duration, and liver diseases, such as hepatic inflammation, that is proposed to occur via reactive oxygen species. In the present study we have used 21-day social isolation of male Wistar rats as a model of chronic stress to investigate protein expression/activity of liver antioxidant enzymes: superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR), and protein expression of their upstream regulators: glucocorticoid receptor (GR) and nuclear factor kappa B (NFkB). We have also characterized these parameters in either naive or chronically stressed animals that were challenged by 30-min acute immobilization. We found that chronic isolation caused decrease in serum corticosterone (CORT) and blood glucose (GLU), increase in NFkB signaling, and disproportion between CuZnSOD, peroxidases (CAT, GPx) and GLR, thus promoting H 2 O 2 accumulation and prooxidative state in liver. The overall results suggested that chronic stress exaggerated responsiveness to subsequent stressor at the level of CORT and GLU, and potentiated GLR response, but compromised the restoration of oxido-reductive balance due to irreversible alterations in MnSOD and GPx

A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead

The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (alpha-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics

Dietary fat intake as a risk factor for the development of diabetes. Multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGDS)

In the context of the Multinational MGSD Nutrition Study, three groups of subjects were studied: 204 subjects with recently diagnosed diabetes(RDM),42subjectswithundiagnoseddiabetes(UDM)(AmericanDiabetesAssociation criteria—fasting plasma glucose [FPG] 126 mg/dl), and 55 subjects with impaired fasting glucose(IFG)(FPG 110and126mg/dl).Eachgroupwascomparedwithacontrolgroupof nondiabetic subjects, matched one by one for center, sex, age, and BMI. Nutritional habits were evaluated by a dietary history method, validated against the 3-day diet diary. In RDM, the questionnaire referred to the nutritional habits before the diagnosis of diabetes. Demographic data were collected, and anthropometrical and biochemical measurements were taken. RESULTS— Compared with control subjects, RDM more frequently had a family history of diabetes(49.0vs.14.2%;P0.001),exercisedless(exerciseindex53.5vs.64.4;P0.01),and more frequently had sedentary professions (47.5 vs. 27.4%; P 0.001). Carbohydrates contributed less to their energy intake (53.5 vs. 55.1%; P 0.05), whereas total fat (30.2 0.5 vs. 27.8 0.5%; P 0.001) and animal fat (12.2 0.3 vs. 10.8 0.3%; P 0.01) contributed moreandtheplant-to-animalfatratiowaslower(1.50.1vs.1.80.1;P0.01).UDMmore frequentlyhadafamilyhistoryofdiabetes(38.1vs.19.0%;P0.05)andsedentaryprofessions (58.5vs.34.1%;P0.05),carbohydratescontributedlesstotheirenergyintake(47.61.7vs. 52.81.4%;P0.05),totalfat(34.71.5vs.30.41.2%;P0.05)andanimalfat(14.2 0.9 vs. 10.6 0.7%; P 0.05) contributed more, and the plant-to-animal fat ratio was lower (1.6 0.2 vs. 2.3 0.4; P 0.05). IFG differed only in the prevalence of family history of diabetes (32.7 vs. 16.4%; P 0.05). CONCLUSIONS— Our data support the view that increased animal fat intake is associated with the presence of diabetes

Arsenic toxicity: Molecular targets and therapeutic agents

High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through drinking water and food. Highly exposed individuals may develop acute, subacute, or chronic signs of poisoning, characterized by skin lesions, cardiovascular symptoms, and in some cases, multi-organ failure. Inorganic arsenite(III) and organic arsenicals with the general formula R-As2+ are bound tightly to thiol groups, particularly to vicinal dithiols such as dihydrolipoic acid (DHLA), which together with some seleno-enzymes constitute vulnerable targets for the toxic action of As. In addition, R-As2+-compounds have even higher affinity to selenol groups, e.g., in thioredoxin reductase that also possesses a thiol group vicinal to the selenol. Inhibition of this and other ROS scavenging seleno-enzymes explain the oxidative stress associated with arsenic poisoning. The development of chelating agents, such as the dithiols BAL (dimercaptopropanol), DMPS (dimercapto-propanesulfonate) and DMSA (dimercaptosuccinic acid), took advantage of the fact that As had high affinity towards vicinal dithiols. Primary prevention by reducing exposure of the millions of people exposed to unacceptable As levels should be the prioritized strategy. However, in acute and subacute and even some cases with chronic As poisonings chelation treatment with therapeutic dithiols, in particular DMPS appears promising as regards alleviation of symptoms. In acute cases, initial treatment with BAL combined with DMPS should be considered

Methodological Framework for Analysing Cascading Effects from Flood Events: The Case of Sukhumvit Area, Bangkok, Thailand

This is the final version of the article. Available from MDPI via the DOI in this record.Impacts from floods in urban areas can be diverse and wide ranging. These can include the loss of human life, infrastructure and property damages, as well as other kinds of nuisance and inconvenience to urban life. Hence, the ability to identify and quantify wider ranging effects from floods is of the utmost importance to urban flood managers and infrastructure operators. The present work provides a contribution in this direction and describes a methodological framework for analysing cascading effects from floods that has been applied for the Sukhumvit area in Bangkok (Thailand). It demonstrates that the effects from floods can be much broader in their reach and magnitude than the sole impacts incurred from direct and immediate losses. In Sukhumvit, these include loss of critical services, assets and goods, traffic congestion and delays in transportation, loss of business and income, disturbances and discomfort to the residents, and all these can be traced with the careful analysis of cascading effects. The present work explored the use of different visualization options to present the findings. These include a casual loop diagram, a HAZUR resilience map, a tree diagram and GIS maps.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant Agreement No. 603663 for the research project PEARL (Preparing for Extreme and Rare events in coastaL regions). The authors are grateful to Opticits for providing the HAZUR software licence, within the collaboration of the EU H2020 research project RESCCUE (RESilience to cope with Climate Change in Urban arEas—a multisectorial approach focusing on water) Grant Agreement 700174

Mapping urban infrastructure interdependencies and fuzzy risks

This is the final version of the article. Available from Elsevier via the DOI in this record.In this study, we considered the relationships between different types of CI and services to simulate possible cascading effects during extreme hazard conditions brought on by climate change and how to analyse impacts with limited data resources. An area in central Bristol, UK, was used as the case study to investigate the interdependencies among select assets and services. A wide range of plausible scenarios caused by pipe bursts in the area were simulated using the CADDIES 2D modelling framework, to identify the hotspots with high risk. The impact on CI, including water supply, electricity, wastewater, solid waste, transportation, telecommunication, and emergency services were assessed by the HAZUR tool. The analysis demonstrated that with limited data resources the dynamics of the interdependencies between CI networks can be highlighted and a basis of risk quantification can be established. The same procedure can be repeated to evaluate the impact of other types of hazards, or the compound hazard scenarios to provide a holistic assessment. Therefore, urban planners and managers can further explore options of interventions for setting up strategies to strengthen city resilience.This study is supported by the RESCCUE (RESilience to cope with Climate Change in Urban arEas) project, funded by the European Union Horizon 2020 research and innovation programme (Grant Agreement No. 700174)

Heavy-Quark Diffusion, Flow and Recombination at RHIC

We discuss recent developments in assessing heavy-quark interaction in the Quark-Gluon Plasma (QGP). While induced gluon radiation is expected to be the main energy-loss mechanism for fast-moving quarks, we focus on elastic scattering which prevails toward lower energies, evaluating both perturbative (gluon-exchange) and nonperturbative (resonance formation) interactions in the QGP. The latter are treated within an effective model for D- and B-meson resonances above T_c as motivated by current QCD lattice calculations. Pertinent diffusion and drag constants, following from a Fokker-Planck equation, are implemented into an expanding fireball model for Au-Au collisions at RHIC using relativistic Langevin simulations. Heavy quarks are hadronized in a combined fragmentation and coalescence framework, and resulting electron-decay spectra are compared to recent RHIC data. A reasonable description of both nuclear suppression factors and elliptic flow up to momenta of ~5 GeV supports the notion of a strongly interacting QGP created at RHIC. Consequences and further tests of the proposed resonance interactions are discussed.Comment: 8 pages, 14 figures, contribution to the proceedings for the "International Conference on Strangeness in Quark Matter 2006

The Emerging QCD Frontier: The Electron Ion Collider

The self-interactions of gluons determine all the unique features of QCD and lead to a dominant abundance of gluons inside matter already at moderate $x$. Despite their dominant role, the properties of gluons remain largely unexplored. Tantalizing hints of saturated gluon densities have been found in $e$+p collisions at HERA, and in d+Au and Au+Au collisions at RHIC. Saturation physics will have a profound influence on heavy-ion collisions at the LHC. But unveiling the collective behavior of dense assemblies of gluons under conditions where their self-interactions dominate will require an Electron-Ion Collider (EIC): a new facility with capabilities well beyond those In this paper I outline the compelling physics case for $e$+A collisions at an EIC and discuss briefly the status of machine design concepts. of any existing accelerator.Comment: 11 pages, 9 figures, prepared for 20th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions: Quark Matter 2008 (QM2008), Jaipur, India, 4-10 Feb. 200

Jet Quenching in Heavy Ion Collisions

This review article was prepared for the Landolt-Boernstein volume on Relativisitc Heavy Ion Physics.Comment: Review articel accepted for publication in the Landolt-Boernstein Handbook of Physics, ed. R. Stock. 41 pages LaTex, 7 eps-figure