High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate(EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Material and Methods: 28 Wistar rats (Rattus Novergicus) was used and divided into 4 groups accordingly: K- without EGCG and OTM; K+ with OTM, without EGCG for 14 days; T1with OTM for 14 days and EGCG for 7 days; treatment group 2 (T2) with OTM and EGCG for 14 days. OTM animal model was achieved through the installation of the OTM device by means of NiTi close coil spring with 10g force placed between the first incisor and first maxillary molars. The samples were terminated on Day 14. The pre-maxillary was isolated for the immunohistochemical examination. Analysis of Variance (ANOVA) then continued with Tukey Honest Significant Difference (HSD) (p<0.05) was performed to analyze the data. Results: The highest HMGB1 and HSP-70 expression were found in the K+ group pressure side, meanwhile the lowest HMGB1 and HSP-70 expression were found in K- group tension side in the alveolar bone. There was a significant decrease of HMGB1 and HSP-70 expression in T2 compared to T1 and K+ with significant between groups (p<0.05; p=0.0001). Conclusion: The decreased expression of HMGB1 and HSP-70 in alveolar bone of OTM wistar rats due to post administration of GTME that consisted EGCG

High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate (EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Material and Methods: 28 Wistar rats (Rattus Novergicus) was used and divided into 4 groups accordingly: K- without EGCG and OTM; K+ with OTM, without EGCG for 14 days; T1with OTM for 14 days and EGCG for 7 days; treatment group 2 (T2) with OTM and EGCG for 14 days. OTM animal model was achieved through the installation of the OTM device by means of NiTi close coil spring with 10g force placed between the first incisor and first maxillary molars. The samples were terminated on Day 14. The pre-maxillary was isolated for the immunohistochemical examination. Analysis of Variance (ANOVA) then continued with Tukey Honest Significant Difference (HSD) (p&lt;0.05) was performed to analyze the data. Results: The highest HMGB1 and HSP-70 expression were found in the K+ group pressure&nbsp; side, meanwhile the lowest HMGB1 and HSP-70 expression were found in K- group tension side in the alveolar bone. There was a significant decrease of HMGB1 and HSP-70 expression in T2 compared to T1 and K+ with significant between groups (p&lt;0.05; p=0.0001). Conclusion: The decreased expression of HMGB1 and HSP-70 in alveolar bone of OTM wistar rats due to post administration of GTME that consisted EGCG

Meramal Waktu Erupsi Gigi Kaninus Permanen, Premolar Pertama Dan Premolar Kedua

Salah satu, macam perawatan yang dilakukan pada masa, geligi, Pergantian untuk mengatasi keparahan maloklusi adalah pencabutan ser

Correlation between Dentoalveolar Heights and Vertical Skeletal Patterns in Class I Malocclusion in Ethnic Javanese

Objectives Vertical proportions of the face are important determining factors for diagnosis and planning appropriate orthodontic treatment. Orthodontic patients have different vertical and sagittal skeletal Discrepancies, as well as associated varying degrees of dentoalveolar compensations. Dentoalveolar is a functional component of the jaw; it plays a role in occlusal dynamics and forms sagittal and vertical maxilla–mandibula relationships. This study aims to analyze the relationship between dentoalveolar heights and several vertical skeletal patterns in patients with Class I malocclusion in ethnic Javanese. Materials and Methods The sample consisted of lateral cephalograms of 75 patients (18 samples were male, and 57 were female). Determined by inclusion and exclusion criteria, the participants were selected from an initial sample of 196 patients with skeletal Class I malocclusion (sella–nasion–A and B [ANB] = 1–4 degrees). Cephalometric analysis was performed using OrthoVision2017 digital software. This analysis measured upper anterior dental height (UADH), upper posterior dental height (UPDH), lower anterior dental height (LADH), lower posterior dental height (LPDH), ANB angle, sella–nasion and mandibular plane (SN-MP), sella–nasion and palatal plane (SN-PP), palatal plane and mandibular plane (PP-MP), Frankfort horizontal plane and mandibular plane (FH-MP), sella to gonion (S-Go), articulare to gonion (Ar-Go), nasion to menton (N-Me), nasion to anterior nasal spine (N-ANS), and anterior nasal spine to menton (ANS-Me). Pearson correlation test was used to assess correlations among all variables (p < 0.05). Results Significant correlations were observed between dentoalveolar heights and SN-MP, S-Go, Ar-Go, N-Me, and ANS-Me (p < 0.05). Conclusions Patients with Class I malocclusion in ethnic Javanese exhibit a significant correlation between dentoalveolar and vertical skeletal patterns. UPDH and/or LPDH have a significantly positive correlation with SN-MP, S-Go, Ar-Go, N-Me, and ANS-Me. The orthodontic correction of the decreased or increased facial height included either the extrusion or intrusion of the anterior or posterior teeth in different ways