Relationships Among Temperament Characteristics of Adolescents Born Prematurely and Maternal Temperament Characteristics

Abstract available through the Developmental Psychobiology

Testing Assumptions about Laboratory Protocol Fidelity

A recent focus of our Program for the Study of Infancy is the extent to which lab assistants retain fidelity when implementing experimental protocols. Dixon et al. showed that experimenters’ implementations of some aspects of standardized protocols can be influenced by infants’ temperaments. Ellefson and Oppenheimer further found that procedural deviations reduce effect sizes and lead to heterogeneity of findings. In this project, we evaluated archival videos involving experimenters’ implementations of two elicited imitation tasks, “Feed Bear” and “Make a Rattle.” In both tasks, experimenters were assumed to adhere to a narrative script and procedure, which included familiarizing infants with experimental stimuli for 60 seconds prior to infants engaging the tasks. Experimenters were also expected to adhere to a standardized narrative script that accompanied the modeling of “feeding the bear” or “making a rattle.” In this study we explored whether they did so, independent of infants\u27 temperament characteristics. Ten experimenters guided sixty-one 15-month-olds through the experimental procedure. We examined two types of dependent measures reflecting 1) whether experimenters adhered to the 60 second familiarization time protocol, and 2) whether experimenters adhered to the standardized scripts. We also tracked experimenter infant-directed speech (IDS) before the model (prologue IDS) and after the model (epilogue IDS), to see if experimenters’ speech was potentially influenced by infant temperament. Infant temperament was measured by parent-report using the Early Childhood Behavior Questionnaire (ECBQ). For familiarization times in the Feed Bear task, experimenters granted significantly longer times to the infants than they were supposed to [M = 68.72, SD = 17.14; t(28) = 2.74, p = .011]. But there were no differences among the experimenters in familiarization time. For Make a Rattle, experimenters were on-target with their familiarization times (M = 67.64, SD = 21.38). Infant temperament was not associated with familiarization times in either task. In terms of IDS, experimenters used more words in the standardized narratives of both tasks than they were supposed to [M = 123.90, SD = 18.03; t(28) = 7.73, p M = 109.00, SD = 9.52; t(27) = 15.01, p \u3c .001] respectively. There was no association between IDS during the narrative phase and infant temperament. However, there were associations between infant temperament and IDS during the prologue and epilogue phases; namely for effortful control (prologue r = .29, p p \u3c .05), impulsivity (prologue r = .23, p

Temperament, Distraction, and Learning in Toddlerhood

The word- and nonword-learning abilities of toddlers were tested under various conditions of environmental distraction, and evaluated with respect to children\u27s temperamental attentional focus. Thirty-nine children and their mothers visited the lab at child age 21-months, where children were exposed to fast-mapping word-learning trials and nonlinguistic sequential learning trials. It was found that both word- and nonword-learning were adversely affected by the presentation of environmental distractions. But it was also found that the effect of the distractions sometimes depended on children\u27s level of attentional focus. Specifically, children high in attentional focus were less affected by environmental distractions than children low in attentional focus when attempting to learn from a model, whereas children low in attentional focus demonstrated little learning from the model. Translationally, these results may be of use to child health-care providers investigating possible sources of cognitive and language delay

Associations Between Temperamental Negative Affectivity and Parental Anxiety Across Childhood

Extant research suggests a link between child temperamental negativity and parental anxiety and depression. However, most studies focus on temperamental negativity generally, and over fairly short longitudinal time spans. The present study extended the time span well beyond immediate postnatal infancy and explored associations between specific child temperament dimensions, both positive and negative, and parental psychopathology. We expected positive relationships between temperamental negative affectivity and parental mental health problems, but an inverse relation involving temperamental effortful control. Data were collected on child temperament, and parental anxiety and depression, using a cross-sectional design and anonymous survey methodology across five child age groups: infancy (INF; 3 - 13 months, N ≅ 83), toddler (TOD; 14 - 36 months, N ≅ 94), early childhood (EC; 3 - 7 years, N ≅ 81), middle/late childhood (MLC; 8 - 10 years, N ≅ 31), and early adolescence (EA; 10 - 15 years, N ≅ 38). REDCap survey links were published on several dozen social media outlets and relevant listservs. Across all datasets, parental respondents primarily identified as white and female. Child gender distribution was approximately equal between girls and boys. We used the Rothbart family of instruments to assess temperamental negative affectivity and effortful control in each sample (i.e., IBQ-R Short Form, ECBQ Short Form, CBQ Short Form, TMCQ Standard Form, and EATQ-R Short Form, respectively). Parental anxiety was measured by the Generalized Anxiety Disorder Assessment (GAD-7), and parental depression was measured by the Patient Health Questionnaire-9 (PHQ-9). Associations involving child negative affectivity were generally consistent with expectations. Results indicated positive correlations between parental anxiety and child negative affectivity in 4 out of 5 groups (INF: r(83) = .25, p = .02; TOD: r(94) = .27, p = .01; EC: r(81) = .37, p \u3c .001; EA: r(39) = .57, p \u3c .001), and between parental depression and child negative affectivity in all age groups (INF: r(81) = .26, p = .02; TOD: r(91) = .22, p = .03; EAC: r(80) = .26, p = .02; MLC: r(30) = .42, p = .02; EAA: r(37) = .42, p = .01). Effortful control was negatively, but less robustly, correlated with parental anxiety (TOD: r(94) = -.22, p = .03; EAA: r(39) = -.44, p = .02) and depression (TOD: r(91) = -.29, p = .01; MLC: r(30) = .45, p = .01). Although we make no assumptions regarding directions of effect between child temperament and parental mental health, bidirectional influences seem likely. For example, parental mental health problems probably exacerbate temperamental negative affectivity, and temperamental negative affectivity probably exacerbates parental mental health problems. This study provides an important expansion of the timeframes of associations between parental mental health and child temperament

Role of f02 in fluid saturation of oceanic basalt.

Assessing the conditions under which magmas become fluid-saturated has important bearings on the geochemical modelling of magmas because volatile exsolution may profoundly alter the behaviour of certain trace elements that are strongly partitioned in the coexisting fluid1. Saal et al.2 report primitive melt inclusions from dredged oceanic basalts of the Siqueiros transform fault, from which they derive volatile abundances of the depleted mantle, based on the demonstration that magmas are not fluid-saturated at their eruption depth and so preserve the mantle signature in terms of their volatile contents. However, in their analysis, Saal et al.2 consider only fluid−melt equilibria, and do not take into account the homogeneous equilibria between fluid species, which, as we show here, may lead to a significant underestimation of the pressure depth of fluid saturation

Does directly observed therapy (DOT) reduce drug resistant tuberculosis?

<p>Abstract</p> <p>Background</p> <p>Directly observed therapy (DOT) is a widely recommended and promoted strategy to manage tuberculosis (TB), however, there is still disagreement about the role of DOT in TB control and the impact it has on reducing the acquisition and transmission of drug resistant TB. This study compares the portion of drug resistant genotype clusters, representing recent transmission, within and between communities implementing programs differing only in their directly observed therapy (DOT) practices.</p> <p>Methods</p> <p>Genotype clusters were defined as 2 or more patient members with matching IS<it>6110 </it>restriction fragment length polymorphism (RFLP) and spoligotype patterns from all culture-positive tuberculosis cases diagnosed between January 1, 1995 and December 31, 2001. Logistic regression was used to compute maximum-likelihood estimates of odds ratios (ORs) and 95% confidence intervals (CIs) comparing cluster members with and without drug resistant isolates. In the universal DOT county, all patients received doses under direct observation of health department staff; whereas in selective DOT county, the majority of received patients doses under direct observation of health department staff, while some were able to self-administer doses.</p> <p>Results</p> <p>Isolates from 1,706 persons collected during 1,721 episodes of tuberculosis were genotyped. Cluster members from the selective DOT county were more than twice as likely than cluster members from the universal DOT county to have at least one isolate resistant to isoniazid, rifampin, and/or ethambutol (OR = 2.3, 95% CI: 1.7, 3.1). Selective DOT county isolates were nearly 5 times more likely than universal DOT county isolates to belong to clusters with at least 2 resistant isolates having identical resistance patterns (OR = 4.7, 95% CI: 2.9, 7.6).</p> <p>Conclusions</p> <p>Universal DOT for tuberculosis is associated with a decrease in the acquisition and transmission of resistant tuberculosis.</p

Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats

<p>Abstract</p> <p>Background</p> <p>Hemorrhagic shock followed by resuscitation is conceived as an insult frequently induces a systemic inflammatory response syndrome and oxidative stress that results in multiple-organ dysfunction syndrome including acute lung injury. MK-886 is a leukotriene biosynthesis inhibitor exerts an anti inflammatory and antioxidant activity.</p> <p>Objectives</p> <p>The objective of present study was to assess the possible protective effect of MK-886 against hemorrhagic shock-induced acute lung injury via interfering with inflammatory and oxidative pathways.</p> <p>Materials and methods</p> <p>Eighteen adult Albino rats were assigned to three groups each containing six rats: group I, sham group, rats underwent all surgical instrumentation but neither hemorrhagic shock nor resuscitation was done; group II, Rats underwent hemorrhagic shock (HS) for 1 hr then resuscitated with Ringer's lactate (1 hr) (induced untreated group, HS); group III, HS + MK-886 (0.6 mg/kg i.p. injection 30 min before the induction of HS, and the same dose was repeated just before reperfusion period). At the end of experiment (2 hr after completion of resuscitation), blood samples were collected for measurement of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The trachea was then isolated and bronchoalveolar lavage fluid (BALF) was carried out for measurement of leukotriene B₄(LTB₄), leukotriene C₄(LTC₄) and total protein. The lungs were harvested, excised and the left lung was homogenized for measurement of malondialdehyde (MDA) and reduced glutathione (GSH) and the right lung was fixed in 10% formalin for histological examination.</p> <p>Results</p> <p>MK-886 treatment significantly reduced the total lung injury score compared with the HS group (<it>P </it>< 0.05). MK-886 also significantly decreased serum TNF-α & IL-6; lung MDA; BALF LTB₄, LTC₄& total protein compared with the HS group (<it>P </it>< 0.05). MK-886 treatment significantly prevented the decrease in the lung GSH levels compared with the HS group (<it>P </it>< 0.05).</p> <p>Conclusions</p> <p>The results of the present study reveal that MK-886 may ameliorate lung injury in shocked rats via interfering with inflammatory and oxidative pathways implicating the role of leukotrienes in the pathogenesis of hemorrhagic shock-induced lung inflammation.</p

Untangling knowledge creation and knowledge integration in enterprise wikis

A central challenge organizations face is how to build, store, and maintain knowledge over time. Enterprise wikis are community-based knowledge systems situated in an organizational context. These systems have the potential to play an important role in managing knowledge within organizations, but the motivating factors that drive individuals to contribute their knowledge to these systems is not very well understood. We theorize that enterprise wiki initiatives require two separate and distinct types of knowledge-sharing behaviors to succeed: knowledge creation (KC) and knowledge integration (KI). We examine a Wiki initiative at a major German bank to untangle the motivating factors behind KC and KI. Our results suggest KC and KI are indeed two distinct behaviors, reconcile inconsistent findings from past studies on the role of motivational factors for knowledge sharing to establish shared electronic knowledge resources in organizations, and identify factors that can be leveraged to tilt behaviors in favor of KC or KI

Metabolic constituents of grapevine and grape-derived products

The numerous uses of the grapevine fruit, especially for wine and beverages, have made it one of the most important plants worldwide. The phytochemistry of grapevine is rich in a wide range of compounds. Many of them are renowned for their numerous medicinal uses. The production of grapevine metabolites is highly conditioned by many factors like environment or pathogen attack. Some grapevine phytoalexins have gained a great deal of attention due to their antimicrobial activities, being also involved in the induction of resistance in grapevine against those pathogens. Meanwhile grapevine biotechnology is still evolving, thanks to the technological advance of modern science, and biotechnologists are making huge efforts to produce grapevine cultivars of desired characteristics. In this paper, important metabolites from grapevine and grape derived products like wine will be reviewed with their health promoting effects and their role against certain stress factors in grapevine physiology