Aquifers of Nebraska II: The Niobrara Aquifer

The marine shale, chalk, marl, and chalky limestone of the Niobrara Formation directly underlie Quaternary sediments in 23 counties from south-central to northeastern Nebraska. Nevertheless, the formation serves as an aquifer only in and around Cedar, Madison, and Nuckolls counties. Niobrara aquifer wells mostly supply irrigation, domestic, and livestock needs. Two hundred of the approximately 230 active registered wells in Nebraska that are screened entirely in the Niobrara aquifer are in Cedar County and environs. About another 200 wells in this area are screened in both the Niobrara aquifer and overlying Quaternary sediments. Wells screened entirely in the Niobrara aquifer in Cedar County range in total depth from about 50 to 220 ft (15 to 67 m) in both confined and unconfined hydraulic conditions. One-fifth of these wells yield 500 gpm (1,900 lpm) or more. Groundwater in the aquifer generally flows north-northeast through Cedar County toward the Missouri River

Three-dimensional architecture and hydrostratigraphy of cross-cutting buried valleys using airborne electromagnetics, glaciated Central Lowlands, Nebraska, USA

Buried valleys are characteristic features of glaciated landscapes, and their deposits host important aquifers worldwide. Understanding the stratigraphic architecture of these deposits is essential for protecting groundwater and interpreting sedimentary processes in subglacial and ice-marginal environments. The relationships between depositional architecture, topography and hydrostratigraphy in dissected, pre-Illinoian till sheets is poorly understood. Boreholes alone are inadequate to characterize the complex geology of buried valleys, but airborne electromagnetic surveys have proven useful for this purpose. A key question is whether the sedimentary architecture of buried valleys can be interpreted from airborne electromagnetic profiles. This study employs airborne electromagnetic resistivity profiles to interpret the threedimensional sedimentary architecture of cross-cutting buried valleys in a ca 400 km2 area along the western margin of Laurentide glaciation in North America. A progenitor bedrock valley is succeeded by at least five generations of tunnel valleys that become progressively younger northward. Tunnel-valley infills are highly variable, reflecting under-filled and over-filled conditions. Under-filled tunnel valleys are expressed on the modern landscape and contain fine sediments that act as hydraulic barriers. Over-filled tunnel valleys are not recognized in the modern landscape, but where they are present they form hydraulic windows between deep aquifer units and the land surface. The interpretation of tunnel-valley genesis herein provides evidence of the relationships between depositional processes and glacial landforms in a dissected, pre-Illinoian till sheet, and contributes to the understanding of the complex physical hydrology of glacial aquifers in general

Wharton’s jelly-derived mesenchymal stromal cells as a promising cellular therapeutic strategy for the management of graft-versus-host disease

Citation: McGuirk, J. P., Robert Smith, J., Divine, C. L., Zuniga, M., & Weiss, M. L. (2015). Wharton’s jelly-derived mesenchymal stromal cells as a promising cellular therapeutic strategy for the management of graft-versus-host disease. Pharmaceuticals, 8(2), 196-220. doi:10.3390/ph8020196Allogeneic hematopoietic cell transplantation (allo-HCT), a treatment option in hematologic malignancies and bone marrow failure syndromes, is frequently complicated by Graft-versus-host disease (GVHD). The primary treatment for GVHD involves immune suppression by glucocorticoids. However, patients are often refractory to the steroid therapy, and this results in a poor prognosis. Therefore alternative therapies are needed to treat GVHD. Here, we review data supporting the clinical investigation of a novel cellular therapy using Wharton’s jelly (WJ)-derived mesenchymal stromal cells (MSCs) as a potentially safe and effective therapeutic strategy in the management of GVHD. Adult-derived sources of MSCs have demonstrated signals of efficacy in the management of GVHD. However, there are limitations, including: limited proliferation capacity; heterogeneity of cell sources; lengthy expansion time to clinical dose; expansion failure in vitro; and a painful, invasive, isolation procedure for the donor. Therefore, alternative MSC sources for cellular therapy are sought. The reviewed data suggests MSCs derived from WJ may be a safe and effective cellular therapy for GVHD. Laboratories investigated and defined the immune properties of WJ-MSCs for potential use in cellular therapy. These cells represent a more uniform cell population than bone marrow-derived MSCs, displaying robust immunosuppressive properties and lacking significant immunogenicity. They can be collected safely and painlessly from individuals at birth, rapidly expanded and stored cryogenically for later clinical use. Additionally, data we reviewed suggested licensing MSCs (activating MSCs by exposure to cytokines) to enhance effectiveness in treating GVHD. Therefore, WJCs should be tested as a second generation, relatively homogeneous allogeneic cell therapy for the treatment of GVHD. © 2015 by the authors; licensee MDPI, Basel, Switzerland