The “Sing Me a Story” Project: A Study of Songwriting and Its Impact on the Disabled

The “Sing Me a Story” project is an initiative with the purpose to explore the therapeutic effect of songwriting on young adults with disabilities. With sessions taking place over the course of several weeks, the project is inspired by my own experience and incorporates research on the ever-growing field of music therapy. Participants are invited to join me for co-writing sessions where they will help write a song that expresses their original ideas and emotions. As we get to know one another and the songs are written, the goal is for participants to experience greater confidence in conveying and communicating their thoughts to others, with the music acting as a medium of self-expression

Gas-plasma compressional wave coupling by momentum transfer

Pressure disturbances in a gas-plasma mixed fluid will result in a hybrid response, with magnetosonic plasma waves coupled to acoustic waves in the neutral gas. In the analytical and numerical treatment presented here, we demonstrate the evolution of the total fluid medium response under a variety of conditions, with the gas-plasma linkage achieved by additional coupling terms in the momentum equations of each species. The significance of this treatment lies in the consideration of density perturbations in such fluids: there is no 'pure' mode response, only a collective one in which elements of the characteristics of each component are present. For example, an initially isotropic gas sound wave can trigger an anisotropic magnetic response in the plasma, with the character of each being blended in the global evolution. Hence sound waves do not remain wholly isotropic, and magnetic responses are less constrained by pure magnetoplasma dynamics

Relativistic Landau damping of longitudinal waves in isotropic pair plasmas

Landau damping is described in relativistic electron-positron plasmas. Relativistic electron-positron plasma theory contains important new effects when compared with classical plasmas. For example, there are undamped superluminal wave modes arising from both a continuous and discrete mode structure, the former even in the classical limit. We present here a comprehensive analytical treatment of the general case resulting in a compact and useful form for the dispersion relation. The classical pair-plasma case is addressed, for completeness, in an appendix

Chaotic resonances of a Bose-Einstein condensate in a cavity pumped by a modulated optical field

We present a theoretical analysis of a Bose-Einstein condensate (BEC) enclosed in an optical cavity driven by a modulated external laser beam where the cavity-field variable is adiabatically eliminated. The modulation of the amplitude of the pump laser induces nonlinear resonances and the widespread presence of chaotic oscillations even when repulsive atom-atom interactions are negligible. Close to resonance, varying the modulation amplitude by just a few percent causes abrupt and erratic changes to the output laser intensity with peak power increasing by almost an order of magnitude. We also use a simplified model of the BEC-cavity system that considers only a small number of spatial modes of the BEC to show that, despite the disruptive presence of a modulation in the pump beam, the system can still be considered to be low-dimensional

Unplugging the Universe: the neglected electromagnetic consequence of decoupling

This letter concentrates on the non-equilibrium evolution of magnetic field structures at the onset of recombination, when the charged particle current densities decay as neutrals are formed. We consider the effect that a decaying magnetic flux has on the acceleration of particles via the transient induced electric field. Since the residual charged-particle number density is small as a result of decoupling, we shall consider the magnetic and electric fields essentially to be imposed, neglecting the feedback from any minority accelerated population. We find that the electromagnetic treatment of this phase transition can produce energetic electrons scattered throughout the Universe. Such particles could have a significant effect on cosmic evolution in several ways: (i) their presence could delay the effective end of the recombination era; (ii) they could give rise to plasma concentrations that could enhance early gravitational collapse of matter by opposing cosmic expansion to a greater degree than neutral matter could; (iii) they could continue to be accelerated, and become the seed for reionisation at the later epoch $z \approx 10$.Comment: 4 pages, no figure

Simulation of transient energy distributions in sub-ns streamer formation

Breakdown and streamer formation is simulated in atmospheric pressure nitrogen for a 2D planar electrode system. A PIC code with multigrid potential solver is used to simulate the evolution of the non-equilibrium ionization front on sub-nanosecond timescales. The ion and electron energy distributions are computed, accounting for the inclusion of inelastic scattering of electrons, and collisionally excited metastable production and ionization. Of particular interest is the increased production of metastable and low-energy ions and electrons when the applied field is reversed during the progress of the ionization front, giving insight into the improved species yields in nanosecond pulsed systems

Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation

Background: Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response and hypersensitivity reactions. Identifying novel interventions to enhance wound healing and reduce the inflammatory response may improve long-term clinical outcomes. Micro–ribonucleic acids (miRNAs) are noncoding small ribonucleic acids that play a prominent role in the initiation and resolution of inflammation after vascular injury.<p></p> Objectives: This study sought to identify miRNA regulation and function after implantation of bare-metal and drug-eluting stents.<p></p> Methods: Pig, mouse, and in vitro models were used to investigate the role of miRNA in in-stent restenosis.<p></p> Results: We documented a subset of inflammatory miRNAs activated after stenting in pigs, including the miR-21 stem loop miRNAs. Genetic ablation of the miR-21 stem loop attenuated neointimal formation in mice post-stenting. This occurred via enhanced levels of anti-inflammatory M2 macrophages coupled with an impaired sensitivity of smooth muscle cells to respond to vascular activation.<p></p> Conclusions: MiR-21 plays a prominent role in promoting vascular inflammation and remodeling after stent injury. MiRNA-mediated modulation of the inflammatory response post-stenting may have therapeutic potential to accelerate wound healing and enhance the clinical efficacy of stenting

Regulation of Corticosteroidogenic Genes by MicroRNAs

The loss of normal regulation of corticosteroid secretion is important in the development of cardiovascular disease. We previously showed that microRNAs regulate the terminal stages of corticosteroid biosynthesis. Here, we assess microRNA regulation across the whole corticosteroid pathway. Knockdown of microRNA using Dicer1 siRNA in H295R adrenocortical cells increased levels of CYP11A1, CYP21A1, and CYP17A1 mRNA and the secretion of cortisol, corticosterone, 11-deoxycorticosterone, 18-hydroxycorticosterone, and aldosterone. Bioinformatic analysis of genes involved in corticosteroid biosynthesis or metabolism identified many putative microRNA-binding sites, and some were selected for further study. Manipulation of individual microRNA levels demonstrated a direct effect of miR-125a-5p and miR-125b-5p on CYP11B2 and of miR-320a-3p levels on CYP11A1 and CYP17A1 mRNA. Finally, comparison of microRNA expression profiles from human aldosterone-producing adenoma and normal adrenal tissue showed levels of various microRNAs, including miR-125a-5p to be significantly different. This study demonstrates that corticosteroidogenesis is regulated at multiple points by several microRNAs and that certain of these microRNAs are differentially expressed in tumorous adrenal tissue, which may contribute to dysregulation of corticosteroid secretion. These findings provide new insights into the regulation of corticosteroid production and have implications for understanding the pathology of disease states where abnormal hormone secretion is a feature