Antiklerikalismus in Europa

Der Antiklerikalismus verfolgte im 19. Jahrhundert eine grundlegende Neuordnung des Verhältnisses von Staat, Gesellschaft, Kirchen und Religion. Lisa Dittrich erörtert erstmals anhand dreier Länder vergleichend die europäischen Dimensionen der Kirchenkritik und ihre nationalen Spielarten in Presse, Publizistik und persönlichen Netzwerken. Sie zeigt, dass die zentrale Forderung der Antiklerikalen nach Säkularisierung nicht in einem einfachen Gegensatz zu Religion und Kirchen aufging, und liefert damit eine neue Lesart der europäischen Kulturkämpfe des 19. Jahrhunderts

Antiklerikalismus in Europa

Der Antiklerikalismus verfolgte im 19. Jahrhundert eine grundlegende Neuordnung des Verhältnisses von Staat, Gesellschaft, Kirchen und Religion. Lisa Dittrich erörtert erstmals anhand dreier Länder vergleichend die europäischen Dimensionen der Kirchenkritik und ihre nationalen Spielarten in Presse, Publizistik und persönlichen Netzwerken. Sie zeigt, dass die zentrale Forderung der Antiklerikalen nach Säkularisierung nicht in einem einfachen Gegensatz zu Religion und Kirchen aufging, und liefert damit eine neue Lesart der europäischen Kulturkämpfe des 19. Jahrhunderts

A new hotspot for Temminck’s Red Colobus (Piliocolobus badius temminckii) in The Gambia: the feasibility of a community approach to conservation

The geographic range and abundance of Temminck’s red colobus, Piliocolobus badius temminckii, in The Gambia is not well documented. In March 2019, line transect surveys were conducted at a number of data deficient forests in The Gambia to establish species presence or absence, contribute to a greater understanding of the species at a national scale and identify prior- ity sites for conservation. One area around Sambel Kunda in the Central River Region was found to be exceptionally productive with an observed Temminck’s red colobus population of 587 individuals, a maximum group size of 60, and connectivity to robust populations along a riparian corridor to the east. Surveys were supported by the collation of community perceptions using prin- ciples of Rapid Assessment Program (RAP) methodology to evaluate the feasibility of an integrated community development and primate conservation project. The results of interviews and meetings in the Sambel Kunda area revealed an absence of hunting and increasing population trends for all primate species, including red colobus. Excepting the Central River Region, Temminck’s red colobus populations were otherwise in decline or locally extinct, predominantly as a result of indiscriminate hunting to protect agricultural crops. Meetings with the Village Development Committees confirmed that the greatest proximal threat to red colobus in the study area was the rapid escalation in forest clearance to produce charcoal for local markets and timber for export to offset climate-change-induced declines in agricultural revenues. Local Gambians are aware that they urgently need to adopt sustainable forestry practices to mitigate climate change impacts and protect timber and non-timber resources but are currently unsure how they would develop and implement such a model. Given the uncertainty and complex nature of the range-wide threats facing the red colobus populations, we suggest prioritizing the Sambel Kunda area as a site of international importance for the protection and recovery of this Critically Endangered species. A community approach to the conservation of red colobus in the Sambel Kunda area should be implemented without delay through site designation, capacity building for biodiversity monitoring, sustainable for- estry practices, community engagement and education and by growing awareness of Temminck’s red colobus as a flagship species

A Systematic Review of Published Respondent-Driven Sampling Surveys Collecting Behavioral and Biologic Data.

Reporting key details of respondent-driven sampling (RDS) survey implementation and analysis is essential for assessing the quality of RDS surveys. RDS is both a recruitment and analytic method and, as such, it is important to adequately describe both aspects in publications. We extracted data from peer-reviewed literature published through September, 2013 that reported collected biological specimens using RDS. We identified 151 eligible peer-reviewed articles describing 222 surveys conducted in seven regions throughout the world. Most published surveys reported basic implementation information such as survey city, country, year, population sampled, interview method, and final sample size. However, many surveys did not report essential methodological and analytical information for assessing RDS survey quality, including number of recruitment sites, seeds at start and end, maximum number of waves, and whether data were adjusted for network size. Understanding the quality of data collection and analysis in RDS is useful for effectively planning public health service delivery and funding priorities

LogIKTram: Nachhaltiger straßenbahnbasierter Gütertransport

Zunehmender städtischer und regionaler Güterverkehr belastet die Anwohner, Verkehrsteilnehmer und die Umwelt. Das Projekt LogIKTram verfolgt das Ziel, regionalen Güterverkehr von der Straße auf die Schiene zu verlagern und somit eine Entlastung zu erzielen. Diese Idee soll am Beispiel einer Gütertram in der Region Karlsruhe erprobt werden. Dafür entwickelt die Hochschule Offenburg unter anderem ein Logistikkonzept und ein Planungsmodell. Beides wird in einer IKT-Plattform umgesetzt.Increasing urban and regional freight traffic is a source of concern for local residents, road users and the environment. The LogIKTram project pursues the goal of shifting regional freight traffic from road to rail and thus achieving relief. This idea is to be tested using the example of a cargo tram in the Karlsruhe region. To this end, Offenburg University of Applied Sciences is developing, a logistics concept and a planning model. Both will be implemented in an ICT platform

Optical characterization with filter-on-chip CMOS sensor-systems

Mosaic filter-on-chip CMOS sensors enable the parallel acquisition of spatial and spectral information. These mosaic sensors are characterized by spectral filters which are applied directly on the sensor pixel in a matrix which is multiplied in the x- and y-direction over the entire sensor surface. Current mosaic sensors for the visible wavelength range using 9 or 16 different spectral filters in 3×3 or 4×4 matrices. Methods for the reconstruction of spectral reflectance from multispectral resolving sensors have been developed. It is known that the spectral reflectance of most natural objects can be approximated with a limited number of spectral base functions. In these cases continuous spectral distributions can be reconstructed from multispectral data of a limited number of channels. This paper shows how continuous spectral distributions can be reconstructed using spectral reconstruction methods like Moore-Penrose pseudoinverse, Wiener estimation, Polynomial reconstruction and Reverse principal component analysis. These methods will be evaluated with monolithic mosaic sensors. The Goodness of Fit Coefficient and the CIE color difference are used to evaluate the reconstruction results

Global Cortical Atrophy Is Associated with an Unfavorable Outcome in Stroke Patients on Oral Anticoagulation.

INTRODUCTION Measures of cerebral small vessel disease (cSVD), such as white matter hyperintensities (WMH) and cerebral microbleeds (CMB), are associated with an unfavorable clinical course in stroke patients on oral anticoagulation (OAC) for atrial fibrillation (AF). Here, we investigated whether similar findings can be observed for global cortical atrophy (GCA). METHODS Registry-based prospective observational study of 320 patients treated with OAC following AF stroke. Patients underwent magnetic resonance imaging (MRI) allowing assessment of GCA. Using the simplified visual Pasquier scale, the severity of GCA was categorized as follows: 0: no atrophy, 1: mild atrophy; 2: moderate atrophy, and 3: severe atrophy. Using adjusted logistic and Cox regression analysis, we investigated the association of GCA using a composite outcome measure, comprising: (i) recurrent acute ischemic stroke (IS); (ii) intracranial hemorrhage (ICH); and (iii) death. RESULTS In our time to event analysis after adjusting for potential confounders (i.e., WMH, CMB, age, sex, diabetes, arterial hypertension, coronary heart disease, hyperlipidemia, and antiplatelet use), GCA was associated with an increased risk for the composite outcome in all three degrees of atrophy (grade 1: aHR 3.95, 95% CI 1.34-11.63, p = 0.013; grade 2: aHR 3.89, 95% CI 1.23-12.30, p = 0.021; grade 3: aHR 4.16, 95% CI 1.17-14.84, p = 0.028). CONCLUSION GCA was associated with our composite outcome also after adjusting for other cSVD markers (i.e., CMB, WMH) and age, indicating that GCA may potentially serve as a prognostic marker for stroke patients with atrial fibrillation on oral anticoagulation

Impact of type of oral anticoagulants in patients with cerebral microbleeds after atrial fibrillation-related ischemic stroke or TIA: Results of the NOACISP-LONGTERM registry.

Background Cerebral microbleeds (CMBs) may have a differential impact on clinical outcome in stroke patients with atrial fibrillation (AF) treated with different types of oral anticoagulation (OAC). Methods Observational single-center study on AF-stroke-patients treated with OAC. Magnetic-resonance-imaging was performed to assess CMBs. Outcome measures consisted of recurrent ischemic stroke (IS), intracranial hemorrhage (ICH), death, and their combined analysis. Functional disability was assessed by mRS. Using adjusted logistic regression and Cox proportional-hazards models, we assessed the association of the presence of CMBs and OAC type (vitamin K antagonists [VKAs] vs. direct oral anticoagulants [DOACs]) with clinical outcome. Results Of 310 AF-stroke patients treated with OAC [DOACs: n = 234 (75%); VKAs: n = 76 (25%)], CMBs were present in 86 (28%) patients; of these, 66 (77%) received DOACs. In both groups, CMBs were associated with an increased risk for the composite outcome: VKAs: HR 3.654 [1.614; 8.277]; p = 0.002; DOACs: HR 2.230 [1.233; 4.034]; p = 0.008. Patients with CMBs had ~50% higher absolute rates of the composite outcome compared to the overall cohort, with a comparable ratio between treatment groups [VKAs 13/20(65%) vs. DOACs 19/66(29%); p < 0.01]. The VKA-group had a 2-fold higher IS [VKAs:4 (20%) vs. DOACs:6 (9%); p = 0.35] and a 10-fold higher ICH rate [VKAs: 3 (15%) vs. DOACs: 1 (1.5%); p = 0.038]. No significant interaction was observed between type of OAC and presence of CMBs. DOAC-patients showed a significantly better functional outcome (OR 0.40 [0.17; 0.94]; p = 0.04). Conclusions In AF-stroke patients treated with OAC, the presence of CMBs was associated with an unfavorable composite outcome for both VKAs and DOACs, with a higher risk for recurrent IS than for ICH. Strokes were numerically higher under VKAs and increased in the presence of CMBs. Clinical trial registration http://www.clinicaltrials.gov, Unique identifier: NCT03826927

The impact of competing stroke etiologies in patients with atrial fibrillation.

BACKGROUND Data on the impact of competing stroke etiologies in stroke patients with atrial fibrillation (AF) are scarce. METHODS We used prospectively obtained data from an observational registry (Novel-Oral-Anticoagulants-in-Ischemic-Stroke-Patients-(NOACISP)-LONGTERM) of consecutive AF-stroke patients treated with oral anticoagulants. We compared the frequency of (i) the composite outcome of recurrent ischemic stroke (IS), intracerebral hemorrhage (ICH) or all-cause death as well as (ii) recurrent IS alone among AF-stroke patients with versus without competing stroke etiologies according to the TOAST classification. We performed cox proportional hazards regression modeling adjusted for potential confounders. Furthermore, the etiology of recurrent IS was assessed. RESULTS Among 907 patients (median age 81, 45.6% female), 184 patients (20.3%) had competing etiologies, while 723 (79.7%) had cardioembolism as the only plausible etiology. During 1587 patient-years of follow-up, patients with additional large-artery atherosclerosis had higher rates of the composite outcome (adjusted HR [95% CI] 1.64 [1.11, 2.40], p = 0.017) and recurrent IS (aHR 2.96 [1.65, 5.35 ], p < 0.001), compared to patients with cardioembolism as the only plausible etiology. Overall 71 patients had recurrent IS (7.8%) of whom 26.7% had a different etiology than the index IS with large-artery-atherosclerosis (19.7%) being the most common non-cardioembolic cause. CONCLUSION In stroke patients with AF, causes other than cardioembolism as competing etiologies were common in index or recurrent IS. Concomitant presence of large-artery-atherosclerosis seems to indicate an increased risk for recurrences suggesting that stroke preventive means might be more effective if they also address competing stroke etiologies in AF-stroke patients. CLINICAL TRIAL REGISTRATION NCT03826927