Renal impairment as a possible side effect of gabapentin - A single case report

A bipolar I manic patient was treated successfully by adding gabapentin to perazine and clonazepam. Also initially tolerated well, an increase of creatinine after several weeks of GP (2000 mg) was observed which was reversible after discontinuation of GP. It is suggested that the possibility of renal dysfunction should be kept in mind with the usage of gabapentin

Wall thickness optimization of a transpiration-cooled sharp leading edge at atmospheric re-entry

The purpose of this paper is to find the necessary cooling mass flow for a defined wall thickness distribution, which allows a selective cooling for an acceptable temperature range of the sharp leading edge of an atmospheric re-entry vehicle. Due to the angle of attack during the re-entry flight the pressure at the top side is lower than the pressure at the bottom side. However, the highest heat load occurs at the stagnation point at which also the maximum pressure is effective. The efficiency of a transpiration cooling depends on the mass flow rate of the coolant. The cooling mass flow is therefore determined by the pressure difference between the ambient and reservoir pressure. Thus, the coolant mass flow increases if the pressure difference between the reservoir and ambient pressure increases. If so a vehicle dives into earth atmosphere, the maximum coolant mass flow is expected in a higher atmosphere. In particular, the cooling effect on the surface caused by the different pressures between top side and bottom side will be considered in more detail. These different pressures are resulting from oblique shocks caused by an angle of attack with α=5°. A possibility to compensate this effect is to adapt the wall thickness so that the coolant mass flow is constant over the transpiration cooled surface, or higher on the hot side. For this purpose the numerical code Heat Exchange Analysis for Transpiration-cooling Systems (HEATS) will be adapted to compute the temperature distribution for a defined transpiration cooled leading edge geometry and trajectory. The results are showing, for a constant mass flow for top side and bottom side, a temperature difference of about 500K at the surface, only caused by the angle of attack. In addition, the impact to the reservoir pressure is higher than 0.5bar, if the cooling mass flow is assumed as constant

Non-Destructive Method for Radiolabelling Biomolecules by Halogenation

A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro secondary amine, (b) reacting the N-chloro secondary amine with a salt of a radiolabelled halogen to produce a radiolabelled halogenating agent, (c) reacting a solution of the biomolecule substrate with the radiolabelled halogenating agent, and (d) recovering a radiohalogenated biomolecule from the reaction of step (c). The kit and method allow for more complete iodination with a lessening of side reactions such as decomposition of the biomolecule substrate to be labelled

Klimagasemission im Futterbau: Vergleich von leguminosenbasierten und intensiv stickstoffgedüngten Grünlandbeständen

Aim of the presented study was the comparison of the specific emissions of CO2 equivalents of a legume based and a mineral N fertilised grassland considering the N2O emissions caused by N fertilisation and soil compaction. The field trial was set up on the experimental station “Hohenschulen” in northern Germany with the factors soil compaction, N fertilisation and experimental year. The N2O emissions were affected by an interaction of soil compaction and N fertilisation, especially under moist spring conditions. The specific CO2-equivalent emission per unit energy yield was 67 % higher for the mineral N-fertilised grassland compared to the legume based grassland

N-Chloro-N-Methyl Glucamine and N-Chloro-N-Methyl Glucamine Esters as Novel Safe Agents for Water Disinfetion

The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules

Derivatives of N-Chloro-N-Methyl Glucamine and N-Chloro-N-Methyl Glucamine Esters

The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules

Mechanisms of Phosphorous Uptake Efficiency of Safflower and Sunflower Grown in Different Soils

Plant species vary in their phosphorous (P) use efficiency under suboptimal P supplies using different strategies, but the mechanisms are not clearly documented for some alternative plant species. Safflower was considered as low input oil crop, but its P uptake efficiency mechanism was not fully investigated. Therefore P uptake efficiency of safflower was studied as compared to sunflower under semi-controlled conditions in sandy and loamy soils. Both species responded strongly to increasing P supplies in both soils and performed better in loamy soil. Both species had similar agronomic P efficiency in both soils, indicated by similar external P requirement under P-deficient conditions. Under P deficiency, safflower had less relative shoot and root production when they were grown in sandy soils and the opposite was found in terms of loamy soil. Safflower had the disadvantage of less root length and root shoot ratio in both soils under low and high P supplies but had the advantage of higher specific root density, less root radius, and slower shoot growth rate. Under P deficiency in both soil types, both species responded similarly in terms of P influx, depleting P from soil solution and P concentration in shoots. Under high P supply, P influx and P concentration in shoots was less in safflower in both soil types. Safflower was characterized by higher shoot demand on roots for P under low and high P supplies in both soil types. Therefore the cause of high root demand on P in safflower roots at low and high P supplies stems from the low root shoot ratio of safflower at both P supplies, low P concentration and low P influx of safflower at high P supplies not because of higher shoot growth rate of safflower at low and high P supplies. Therefore using different measures of utilization efficiency parameters to differentiate plant species and genotypes to superior and inferior could be in some cases misleading.Financial support for this study was obtained from the German Academic Exchange Service (DAAD), through a Re-invitation Programme for Former Scholarship Holders (A/12/08202 and 50068612), the Palestinian funding program for research and training “ZAMALAH”, and the Dutch EP-NUFFIC through NICHE-233 project. Technical support by Mrs. S. Koch in department of plant nutrition and yield physiology, George-August University, Goettingen, Germany for her generous help in plant and soil samples analyses is gratefully acknowledged

Desenvolvimento de métodos para a determinação simultânea de cromo e ferro e de cobalto e vanádio em óleo cru usando análise direta por espectrometria de abosorção atômica de alta resolução com fonte contínua e atomização em forno de grafite

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Foram desenvolvidos métodos para a determinação simultânea de Cr e Fe e de Co e V em amostras de óleo cru por espectrometria de absorção atômica de alta resolução com fonte contínua com forno de grafite (HR CS GF AAS) com introdução direta da amostra e calibração externa com padrões aquosos. As medidas simultâneas foram realizadas na linha principal do Cr em 357,868 nm, e na linha secundária de Fe em 358,120 nm; na linha principal do Co em 240,725 nm e na linha secundária do V em 240,674 nm, nas temperaturas de pirólise e atomização otimizadas. Para verificar a exatidão dois CRM de óleo cru foram analisados. A determinação de Co e V foi realizada sem e com o uso de modificador. Massas características de 3,6 pg e 0,5 ng foram obtidas para Cr e Fe, respectivamente. Os limites de detecção (3 s, n = 10) foram determinados como 1 µg kg-1 para Cr e 0,6 mg kg-1 para Fe, e a precisão, expressa como desvio padrão relativo, foi de 4 a 20%. Os limites de detecção foram determinados como 7 e 8 µg kg-1 para Co e para V como 1,0 e 1,2 mg kg-1, sem e com modificador, respectivamente. A precisão variou de 2 a 20%. As massas características encontradas foram 7 e 8 pg para Co, e de 1,4 ng e 2,1 ng para V, sem e com o uso de modificador, respectivamente. Cinco amostras de óleo cru coletadas no Brasil e na Venezuela foram analisadas. A determinação de Co foi realizada utilizando tanto o pixel central 1 e também utilizando as asas da linha 3, dependendo da concentração de Co. Para algumas amostras foi possível determinar a fração volátil de Co e V, que variou de 16 a 19% para Co e 10 a 44% para V

Novel Method of Administering Aspirin and Dosage Forms Containing Same

The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack

"Contribuição da ludicidade para o desenvolvimento da criança de 1ª a 4ª série"

Orientadora: Simone RechiaMonografia (licenciatura) - Universidade Federal do Paraná. Setor de Ciências Biológicas. Curso de Educação Físic