Avaliação sazonal do rendimento e composição química do óleo essencial das folhas de Aniba parviflora (Meisn) Mez. (Lauraceae) / Seasonal evaluation of yield and chemical composition of the essential oil of the leaves of Aniba parviflora (Meisn) Mez. (Lauraceae)

Os óleos essenciais das folhas de um espécime de Aniba parviflora (Meisn) Mez. (Lauraceae) coletadas nos meses de setembro e dezembro de 2016 e março de 2017 Belém, (Pará/Brasil), foram obtidos por hidrodestilação e analisados através de cromatografia de fase gasosa acoplada à espectrometria de massas (CG/EM). Os principais constituintes químicos identificados nos óleos essenciais das folhas de A. parviflora foram os monoterpenos: linalol, com variações de 14,07% (setembro) a 28,42% (março), ?-felandreno 5,66% (setembro) a 14,87% (março), p-cimeno 2,74% (setembro) a 17,54% (março), e o sesquiterpeno oxigenado espatulenol de 3,79% (dezembro) a 7,0% (setembro). 

Iron overload in Brazilian thalassemic patients

Objectives: To evaluate the use of magnetic resonance imaging inpatients with β-thalassemia and to compare T2* magnetic resonanceimaging results with serum ferritin levels and the redox active fraction of labile plasma iron. Methods: We have retrospectively evaluated 115 chronically transfused patients (65 women). We tested serum ferritin with chemiluminescence, fraction of labile plasma iron by cellular fluorescence and used T2* MRI to assess iron content in the heart, liver, and pancreas. Hepatic iron concentration was determined in liver biopsies of 11 patients and the results were compared with liver T2* magnetic resonance imaging. Results: The mean serum ferritin was 2,676.5 +/- 2,051.7 ng/mL. A fraction of labile plasma iron was abnormal (> 0,6 Units/mL) in 48/83 patients (57%). The mean liver T2* value was 3.91 ± 3.95 ms, suggesting liver siderosis in most patients (92.1%). The mean myocardial T2* value was 24.96 ± 14.17 ms and the incidence of cardiac siderosis (T2* < 20 ms) was 36%, of which 19% (22/115) were severe cases (T2* < 10 ms). The mean pancreas T2* value was 11.12 ± 11.20 ms, and 83.5% of patients had pancreatic iron deposition (T2* < 21 ms). There was significant curvilinear and inverse correlation between liver T2* magnetic resonance imaging and hepatic iron concentration (r= -0.878; p < 0.001) and moderate correlation between pancreas and myocardial T2* MRI (r = 0.546; p < 0.0001). Conclusion: A high rate of hepatic, pancreatic and cardiac impairment by iron overload was demonstrated. Ferritin levels could not predict liver, heart or pancreas iron overload as measured by T2* magnetic resonance imaging. There was no correlation between liver, pancreas, liver and myocardial iron overload, neither between ferritin and fraction of labile plasma iron with liver, heart and pancreas T2* values