Universities’ Entrepreneurship Education and Regional Development: a Stakeholders’ Approach

It is assumed that entrepreneurship education encourage the growth of new businesses, exploiting the entrepreneurial spirit within higher education sector. Additionally, entrepreneurship higher education is supposed to play a relevant role in the development of enterprising citizens and in the development regions through an ongoing process of knowledge creation and delivery. In this research we will explore what roles are attributed to entrepreneurship education in the literature with regard to regional development as well as the influence and relationship of the main intervening stakeholders. The aim is to present a conceptual model which integrate the contributions of both strands of literature and, at the same time, highlight the interplay between the several stakeholders involved in HEI’s entrepreneurship education and regional development.Entrepreneurship education, university, regional development, stakeholders

O DUPLO VÍNCULO ENTRE A DÁDIVA RELIGIOSA E MEDIÁTICA

Este artigo condensa resultados de uma pesquisa sobre um fenômeno midiático-religiosa, do movimento carismático no Brasil, liderado por Padre Robson de Oliveira. Mobilizando o método abdutivo, apresenta um conjunto de inferências a partir de indícios, mobilizando operações inferenciais diversas. Estas inferências se referem ao a participação dos fiéis em contexto religioso, a configuração do circuito midiático construído e à constituição do Padre Robson em líder carismático, referenciado em processos midiáticos retroalimentados, na perspectiva da midiatização. Buscamos, nas inferências transversais, localizar esse fenômeno como parte das transformações dos fenômenos religiosos no Brasil, acionadas e articuladas com observações das interações e fluxos em meios-dispositivos

The development of an excellence model integrating the Shingo model and sustainability

Companies are continuously looking to improve their production systems using excellence models, with lean thinking, the Shingo model, six sigma and lean six sigma being the most comprehensive and applied. It is expected that the initial focus for the survival of companies is their economic profitability, but when economic needs are met, the next step is to achieve operational excellence. For this, in addition to economic objectives, it is necessary to include social and environmental objectives, i.e., the other two pillars of sustainability. This study aims to propose a conceptual model identifying the tools that can help achieve the desired results in the three pillars of sustainability aligned with operational excellence. The design of the conceptual model was based on a bibliometric analysis of the literature that relates the concepts of lean thinking, six sigma, lean six sigma and the Shingo model. The Web of Science was the platform selected for the collection of data, and the timeframe considered was 2010 to 2021. A total of 125 articles were analyzed using the VosViewer software, through which it was possible to analyze different topics of study related to the literature. The bibliometric analysis allowed for the identification of the temporal distribution of publications, the categorization of topics, different areas of application and the importance of the tools used in different practical cases. This study points out that companies have at their disposal several tools to achieve economic objectives. On the other hand, there is a set of more restricted tools that are used to meet the objectives of the social and environmental pillars. Future research should focus on identifying tools that meet social and environmental goals in order to strengthen these pillars that are essential for operational excellence and for the sustainability of companies.The work of the author Vanda Lima is supported by national funds, through the FCT-Portuguese Foundation for Science and Technology under the project UIDB/04728/2020

Behavioural Ecology Traits of Elusive Deep-Diver Whales Unravel a Complex Social Structure Influenced by Female Philopatry and Defence Polygyny

Knowledge of the role of individual associations has provided an insightful understanding of the structures of animal societies, especially in highly social mammals such as primates. Yet, this is unbalanced towards marine mammals, particularly to beaked whales, due to their elusive nature. In addition, information on the fundamental drivers of the social structure of these deep-diving animals is still scarce. Here, the hypothesis of female defence polygyny was tested in Blainville’s beaked whales (Mesoplodon densirostris) and discussed within the context of marine and terrestrial organisms displaying similar patterns, by (i) estimating residency times to obtain information on the movements into and out of the area, (ii) analysing social networks to assess individual association metrics, (iii) measuring the strength of the associations to assess the existence of preferred or avoided relationships among individuals, and (iv) modelling different social structures to address temporal patterns in social relationships. Using a 9-year photographic dataset derived from the pelagic habitat, individual associations were inferred based on likelihood techniques. This approach allowed to infer on the species’ social structure in relation to age class, sex, residency status, and spatio-temporal patterns, which can be a good practice to be applied for other taxa. Heterogeneity in capture probability and residency times was observed between age-sex classes, with adult females exhibiting long-term site fidelity. This suggests different habitat roles and spatial structuring within this social organisation. Strong and long dyadic associations occurred between adult females and immatures, contrarily to between males, and the best-fitting models of the temporal patterns suggested long-lasting and temporary associations. The present findings unravel a complex social structure stratified by age-sex class and influenced by female philopatry and defence polygyny, like an unimale group mating system, which varies from other beaked whales but is similar to some birds, pinnipeds, or non-human primates.FUNDING: The Oceanic Observatory of Madeira and the Portuguese Foundation for Science and Technology (FCT) throughout the strategic projects M1420-01-0142-FEDER-000001 and UIDB/04292/2020, respectively. AB was supported by a MARE grant throughout the project UIDB/04292/2020, AD by ARDITI throughout the project M1420-09-5369-FSE-000002, RF by the FCT grant SFRH/BD/147225/2019, AS by the FCT grant SFRH/BD/141609/2018, MF by the MAC2/1.1a/385 in the framework of INTERTAGUA (MAC INTERREG 2014-2020), and FA by the FCT project UIDP/04292/2020 granted to MARE.info:eu-repo/semantics/publishedVersio

The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis

Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of L. donovani infection by analyzing the parasite burden in the spleen and liver of the infected pMT-10 and WT mice as well as the histopathological alterations upon IL-10 induction. Furthermore, the profile of cytokines expressed by T cells was assessed. Our results demonstrate that an increase in IL-10 production has an impact early but not later after infection. This specific temporal role for IL-10-mediated susceptibility to VL is of interest.Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013) and the Fundação para a Ciência e Tecnologia (FCT) (contracts SFRH/BD/120127/2016 to IM, PD/BDE/127830/2016 to CF, SFRH/BD/120371/2016 to AMB, IF/01147/2013 to RDO, IF/01390/2014 to ET, IF/00735/2014 to AC, SFRH/BPD/96176/2013 to CC and IF/00021/2014 to RS), and Infect-Era (project INLEISH). JE also thanks the Canada Research Chair program for financial assistanceinfo:eu-repo/semantics/publishedVersio

Mechanical behaviour analysis of polyester polymer mortars modified with recycled GFRP waste materials

In this study the effect of incorporation of recycled glass-fibre reinforced polymer (GFRP) waste materials, obtained by means of milling processes, on mechanical behaviour of polyester polymer mortars was assessed. For this purpose, different contents of recycled GFRP waste powder and fibres, with distinct size gradings, were incorporated into polyester based mortars as sand aggregates and filler replacements. Flexural and compressive loading capacities were evaluated and found better than unmodified polymer mortars. GFRP modified polyester based mortars also show a less brittle behaviour, with retention of some loading capacity after peak load. Obtained results highlight the high potential of recycled GFRP waste materials as efficient and sustainable reinforcement and admixture for polymer concrete and mortars composites, constituting an emergent waste management solution

Sports career for swimmers : what, where and how long will swim?

Introdu??o: Uma carreira esportiva apresenta diversas fases de desenvolvimento e apresentam caracter?sticas espec?ficas. Uma avalia??o longitudinal necessita conhecimento sobre a carreira dos atletas e resultado em competi??es. Objetivo: Analisar os resultados da carreira de nadadores do Estado de Minas Gerais, durante o per?odo de 2002 ? 2016, e identificar as prefer?ncias competitivas (tipos de prova), transfer?ncias para outros clubes e o momento do abandono desses nadadores. M?todo: Foram analisados os resultados das principais competi??es estaduais da carreira esportiva de 4756 nadadores. Os dados foram coletados no site da federa??o estadual e transcritos em uma tabela, foi realizada an?lise descritiva e inferencial. Resultados: A partir da an?lise dos resultados, das categorias mirim ? s?nior, foi poss?vel estabelecer que os atletas optam por competir em menores dist?ncias e no nado livre, que o tempo para se transferirem de um clube ? de dois anos e que o abandono ocorre pr?ximo aos 14 anos. Conclus?o: Conclui-se que que os atletas preferem provas de velocidade, que a carreira da maioria dos atletas ? breve, e que os melhores resultados precedem o abandono, aos 14 anos.Background: A sports career has several developmental stages and specific characteristics. A longitudinal assessment needs knowledge about the athletes? career and results in competitions. Objective: To analyze the career outcomes of swimmers from the State of Minas Gerais, from 2002 to 2016, and to identify competitive preferences (types of events), transfers to other clubs and the timing of their abandonment. Method: The results of the main state sports competitions of 4756 swimmers were analyzed. Data were collected from the state federation?s website and transcribed in a table. Descriptive and inferential analysis was performed. Results: From the analysis of the results, from child to senior categories, it was possible to establish that athletes choose to compete in shorter distances and freestyle, that the time to transfer from a club is two years and that abandonment occurs close to 14 years old. Conclusion: It is concluded that athletes prefer short distance events, that the career of most athletes is short, and that the best results precede abandonment at 14 years

Alzheimer's Disease: a Review of its Visual System Neuropathology. Optical Coherence Tomography-a Potential Role As a Study Tool in Vivo

Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic changes occur in visual function, including visual field defects, abnormal contrast sensitivity, abnormalities in color vision, depth perception deficits, and motion detection abnormalities. These visual changes were initially believed to be solely due to neurodegeneration in the posterior visual pathway. However, evidence from pathology studies in both animal models of AD and humans has demonstrated that neurodegeneration also takes place in the anterior visual pathway, with involvement of the retinal ganglion cells' (RGCs) dendrites, somata, and axons in the optic nerve. These studies additionally showed that patients with AD have changes in retinal and choroidal microvasculature. Pathology findings have been corroborated in in-vivo assessment of the retina and optic nerve head (ONH), as well as the retinal and choroidal vasculature. Optical coherence tomography (OCT) in particular has shown great utility in the assessment of these changes, and it may become a useful tool for early detection and monitoring disease progression in AD. The authors make a review of the current understanding of retinal and choroidal pathological changes in patients with AD, with particular focus on in-vivo evidence of retinal and choroidal neurodegenerative and microvascular changes using OCT technology.info:eu-repo/semantics/publishedVersio

Euclid preparation. TBD. The effect of linear redshift-space distortions in photometric galaxy clustering and its cross-correlation with cosmic shear

Cosmological surveys planned for the current decade will provide us with unparalleled observations of the distribution of galaxies on cosmic scales, by means of which we can probe the underlying large-scale structure (LSS) of the Universe. This will allow us to test the concordance cosmological model and its extensions. However, precision pushes us to high levels of accuracy in the theoretical modelling of the LSS observables, in order not to introduce biases in the estimation of cosmological parameters. In particular, effects such as redshift-space distortions (RSD) can become relevant in the computation of harmonic-space power spectra even for the clustering of the photometrically selected galaxies, as it has been previously shown in literature studies. In this work, we investigate the contribution of linear RSD, as formulated in the Limber approximation by arXiv:1902.07226, in forecast cosmological analyses with the photometric galaxy sample of the Euclid survey, in order to assess their impact and quantify the bias on the measurement of cosmological parameters that neglecting such an effect would cause. We perform this task by producing mock power spectra for photometric galaxy clustering and weak lensing, as expected to be obtained from the Euclid survey. We then use a Markov chain Monte Carlo approach to obtain the posterior distributions of cosmological parameters from such simulated observations. We find that neglecting the linear RSD leads to significant biases both when using galaxy correlations alone and when these are combined with cosmic shear, in the so-called 3$\times$2pt approach. Such biases can be as large as $5\,\sigma$-equivalent when assuming an underlying $\Lambda$CDM cosmology. When extending the cosmological model to include the equation-of-state parameters of dark energy, we find that the extension parameters can be shifted by more than $1\,\sigma$.Comment: 15 pages, 5 figures. To be submitted in A&

Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients

The clinical significance of ERBB2 amplification/overexpression in gastric cancer remains unclear. In this study, we evaluated the ERBB2 status in 463 gastric carcinomas using immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), and compared the findings with histopathological characteristics and with disease-specific survival. ERBB2 overexpression (2+ and 3+) and amplification (ratio ERBB2/CEP17⩾2) were found in 43 (9.3%) and 38 (8.2%) gastric carcinomas, respectively. Perfect IHC/FISH correlation was found for the 19 cases scored as 0 (all negative by FISH), and also for the 25 cases scored as 3+ (all positive by FISH). One out of six carcinomas scored as 1+ and 12 out of 18 carcinomas scored as 2+ were positive by FISH. ERBB2 amplification was associated with gastric carcinomas of intestinal type (P=0.007) and with an expansive growth pattern (P=0.021). ERBB2 amplification was detected in both histological components of two mixed carcinomas, indicating a common clonal origin. A statistically significant association was found between ERBB2 amplification and worse survival in patients with expansive gastric carcinomas (P=0.011). We conclude that ERBB2 status may have clinical significance in subsets of gastric cancer patients, and that further studies are warranted to evaluate whether patients whose gastric carcinomas present ERBB2 amplification/overexpression may benefit from therapy targeting this surface receptor