Ethyl 5,8-dibromo-2-dibromo­methyl-6,7-dimeth­oxyquinoline-3-carb­oxy­late

The title compound, C15H13Br4NO4, was obtained via radical bromination reaction of ethyl 6,7-dimeth­oxy-2-methyl­quinoline-3-carboxyl­ate and N-bromo­succinimide (NBS) in the presence of benzoyl peroxide (BPO) under photocatalytic conditions. The quinoline ring system is approximately planar with a maximum deviation from the mean plane of 0.035 (1) Å. The dihedral angle between the six-membered rings is 2.33 (2)°. The meth­oxy O atoms of the two neighboring meth­oxy groups are in-plane while their methyl C atoms are located on either side of the quinolyl ring plane at distances of −1.207 (1) and 1.223 (1) Å

2-(3-Morpholino­prop­yl)-2,3-dihydro-1H-pyrrolo­[3,4-b]quinolin-1-one monohydrate

In the title compound, C18H21N3O2·H2O, the fused-ring system is approximately planar [maximum atomic deviation = 0.028 (3) Å]; the morpholine ring displays a chair conformation. The crystal packing is stabilized by classical inter­molecular O—H⋯O and O—H⋯N hydrogen bonds and weak C—H⋯O hydrogen bonds between the organic mol­ecules and the water mol­ecules

LNK suppresses interferon signaling in melanoma.

LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth and survival in adverse conditions. Forced expression of LNK inhibits signaling by interferon-STAT1 and suppresses interferon (IFN) induced cell cycle arrest and cell apoptosis. In contrast, silencing LNK expression by either shRNA or CRISPR-Cas9 potentiates the killing effect of IFN. The IFN-LNK signaling is tightly regulated by a negative feedback mechanism; melanoma cells exposed to IFN upregulate expression of LNK to prevent overactivation of this signaling pathway. Our study reveals an unappreciated function of LNK in melanoma and highlights the critical role of the IFN-STAT1-LNK signaling axis in this potentially devastating disease. LNK may be further explored as a potential therapeutic target for melanoma immunotherapy

Large Possible retardation effects of quark confinement on the meson spectrum II

We present the results of a study of heavy-light-quark bound states in the context of the reduced Bethe-Salpeter equation with relativistic vector and scalar interactions. We find that satisfactory fits may also be obtained when the retarded effect of the quark-antiquark interaction is concerned.Comment: 11 pages, RevTex, to appear in PR

Possible retardation effects of quark confinement on the meson spectrum

The reduced Bethe-Salpeter equation with scalar confinement and vector gluon exchange is applied to quark-antiquark bound states. The so called intrinsic flaw of Salpeter equation with static scalar confinement is investigated. The notorious problem of narrow level spacings is found to be remedied by taking into consideration the retardation effect of scalar confinement. Good fit for the mass spectrum of both heavy and light quarkomium states is then obtained.Comment: 14 pages in LaTex for

Photosynthetic compensation of non-leaf organ stems of the invasive species Sphagneticola trilobata(L.) Pruski at low temperature

Biological invasion is a hot topic in ecological research. Most studies on the physiological mechanisms of plants focus on leaves, but few studies focus on stems. To study the tolerance of invasive plant (Sphagneticola trilobata L.) to low temperature, relevant physiological indicators (including anthocyanin and chlorophyll) in different organs (leaves and stems) were analyzed, using a native species (Sphagneticola calendulacea L.) as the control. The results showed that, upon exposure to low temperature for 15 days, the stems of two Sphagneticola species were markedly reddened, their anthocyanin content increased, chlorophyll and chlorophyll fluorescence parameters decreased, and the accumulation of reactive oxygen species in the stem increased. The percentage increases of antioxidants and total antioxidant capacities in stems were significantly higher in S. trilobata than in S. calendulacea. This showed that S. trilobata had higher cold tolerance in stems while leaves were opposite. To further verify the higher cold tolerance of the stem of S. trilobata, a defoliation experiment was designed. We found that the defoliated stem of S. trilobata reduced anthocyanin accumulation and increased chlorophyll content, while alleviating membrane lipid damage and electrical conductivity, and the defoliated stem still showed an increase in stem diameter and biomass under low temperature. The discovery of the physiological and adaptive mechanisms of the stem of S. trilobata to low temperature will provide a theoretical basis for explaining how S. trilobata maintains its annual growth in South China. This is of great significance for predicting the future spread of cloned and propagated invasive plants.This work was funded by the National Natural Science Foundation of China (31870374) and the National Key R&D Program of China (2017YFC1200105). The study was also supported by the Innovation Project of Graduate School of South China Normal University

Precision measurement of the branching fractions of J/psi -> pi+pi-pi0 and psi' -> pi+pi-pi0

We study the decays of the J/psi and psi' mesons to pi+pi-pi0 using data samples at both resonances collected with the BES III detector in 2009. We measure the corresponding branching fractions with unprecedented precision and provide mass spectra and Dalitz plots. The branching fraction for J/psi -> pi+pi-pi0 is determined to be (2.137 +- 0.004 (stat.) +0.058-0.056 (syst.) +0.027-0.026 (norm.))*10-2, and the branching fraction for psi' -> pi+pi-pi0 is measured as (2.14 +- 0.03 (stat.) +0.08-0.07 (syst.) +0.09-0.08 (norm.))*10-4. The J/psi decay is found to be dominated by an intermediate rho(770) state, whereas the psi' decay is dominated by di-pion masses around 2.2 GeV/c2, leading to strikingly different Dalitz distributions.Comment: 15 pages, 2 figure