174 research outputs found
Gene Targeting of GAN in Mouse Causes a Toxic Accumulation of Microtubule-Associated Protein 8 and Impaired Retrograde Axonal Transport
History of exposure to herbivores increases the compensatory ability of an invasive plant
Abstract Release from natural enemies is frequently cited as an important factor contributing to plant invasions. But such effects are likely to be temporary-native herbivores can form new plant-herbivore associations and co-evolved insects might reach the new range. While the potential effects of the initial enemy release have been well studied, the consequences of any resumption of herbivory are poorly understood. Alternanthera philoxeroides is one of the most widespread invasive plants in China and is attacked both by a specialist herbivore introduced from the native range, Agasicles hygrophila, and a native beetle Cassida piperata Hope which has formed a new association. However, these insects are not found throughout the invaded range. To test the effect of the history of population exposure to herbivory on compensatory ability, plants were cultured from 14 populations around China that differed in whether A. hygrophila or C. piperata were present. Treatment plants were exposed to herbivory by A. hygrophila for a week until 50% of the leaf area was defoliated, then grown for 80 days. Plants from populations with prior exposure to herbivory (of any kind) accumulated more root mass than populations without prior exposure, indicating that prior exposure to insects can stimulate plant compensation to herbivory. We would recommend that potential changes in plant tolerance in response to prior exposure to herbivory are considered in invasive plant management plans that employ biocontrol agents
Mini Review: Linkages between Essential Tremor and Parkinson\u27s Disease?
Essential tremor (ET) and Parkinson’s disease (PD) are two of the most common movement disorders. Tremors are the primary symptoms of ET and of some PD patients, the two are often mistaken for each other. Especially since there are no available differentiate tests for the tremor of ET or PD, the early diagnoses mainly based on clinical assessments of medical symptoms, family and medication history, and examination by physicians. There is increasing evidence suggesting an association between ET and PD, such as a similar tremor frequency, overlapping resting tremors (a typical PD tremor), postural tremors (mainly in ET patients) in both ET and PD patients, and many ET patients develop PD later in life. Although it is difficult to make a differential diagnosis of ET and tremor-dominant PD based on clinical assessment, recent developments of objective measurements, such as brain imaging, neuropathology, and genetic analysis, has opened a helpful window for distinguishing ET from PD. In this mini review, we included literatures of ET and PD studies and discussed various advanced methods for differential diagnosis between ET and PD such as neuroimaging, genetic markers, tremor intensity and frequency, and drug-responses
In-Situ Radar Observation of Shallow Lunar Regolith at the Chang’E-5 Landing Site : Research Progress and Perspectives
Funding Information: This work is supported by the National Natural Science Foundation of China (Grant No. 42241139 and 42004099), the Opening Fund of the Key Laboratory of Lunar and Deep Space Exploration, Chinese Academy of Sciences (No. LDSE202005), the National Innovation and Entrepreneurship Training Program for College Students (No. 202310590016), the Fund of Shanghai Institute of Aerospace System Engineering (No. PZ_YY_SYF_JY200275), and the Shenzhen Municipal Government Investment Project (No. 2106_440300_04_03_901272).Peer reviewedPublisher PD
Analysis and prediction on the cutting process of constrained damping boring bars based on PSO-BP neural network model
Firstly, this paper computed the static and dynamic characteristics of common boring bars and constrained damping boring bars respectively, and the correctness of the computational model in time-frequency domain was also validated by experiments. Modal frequencies of constrained damping boring bars were obviously more than those of common boring bars, which could effectively avoid structural resonance in low frequency and had an obvious advantage in improving anti-vibration performance of boring bars. The absolute value of the maximum vibration acceleration of common boring bars was 13.1 m/s2, while the absolute value of the maximum vibration acceleration of constrained damping boring bars was 9.1 m/s2. The maximum vibration acceleration decreased by 30.5 %. The maximum vibration displacement of common boring bars was 5.2 mm and corresponding frequency was 201 Hz. The maximum vibration displacement of constrained damping boring bars was 2.3 mm and corresponding frequency was 235 Hz. When the analyzed frequency was lower than the frequency with the maximum vibration displacement, the displacement spectrum of common boring bars had more peak values. Thus, it was clear that constrained damping boring bars had an obvious advantage in improving vibration characteristics. The impact of cutting speed, feed rate and back cutting depth on vibration characteristics was studied respectively. Results showed that the vibration of constrained damping boring bars gradually decreased with the increase of cutting speed and gradually increased with the increase of feed rate and back cutting depth. In addition, the amplitude and frequency of vibration displacement spectrum of boring bars were basically unchanged no matter how cutting parameters changed. In order to quickly predict the vibration characteristic, BP neural network and PSO-BP neural network were respectively used to predict the cutting process of boring bars. When the iteration number of BP neural network was 300, iterative error was 0.00015 which was far more than the set target error. When the iteration number of PSO-BP neural network was 215, iterative error was converged to the set target error. Therefore, PSO-BP neural network had an obvious advantage in predicting the cutting process of boring bars. In addition, the predicted result of PSO-BP neural network was consistent with the experimental result, which showed that the neural network model in this paper was effective
Gigaxonin Interacts with Tubulin Folding Cofactor B and Controls Its Degradation through the Ubiquitin-Proteasome Pathway
SummaryGigaxonin is mutated in human giant axonal neuropathy (GAN), an autosomal recessive neurodegenerative disorder. The presence of generalized cytoskeletal abnormalities [1, 2], including few microtubules and accumulated intermediate filaments (IFs), in GAN suggests an essential role of gigaxonin in cytoskeletal organization and dynamics. However, the molecular mechanisms underlying the cytoskeletal pathology remain to be elucidated. Over the years, the ubiquitin-proteasome system (UPS) of intracellular protein degradation has been implicated in the control of many fundamental cellular processes. Defects in this system seem to be directly linked to the development of human diseases, including cancers and neurodegenerative diseases [3, 4]. Here, we show that gigaxonin controls protein degradation of tubulin folding cofactor B (TBCB) [5], a function disrupted by GAN-associated mutations. The substantial TBCB protein accumulation caused by impaired UPS may be a causative factor of cytoskeletal pathology in GAN. Our study provides important insight into pathogenesis of neurodegenerative diseases associated with cytoskeletal abnormalities
Selenite benefits embryonic stem cells therapy in the animal models of Parkinson’s disease through inhibiting inflammation
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