Mungbean yield and nutrient uptake performance in response of NPK and lime levels under acid soil in Vindhyan region, India

A field experiment was conducted to understanding the management of soil acidity with NPK and lime levels for sustainable mungbean productivity, Crop was sown during kharif season of 2014at Agronomy farm of Rajiv Gandhi South Campus Banaras Hindu University, Barkachha, Mirzapur, Uttar Pradesh. Results of the study demonstrated that significant improvement in seed (524 kg /ha), straw (1426 kg /ha), biological yield (1949 kg/ha) and total NPK uptake (96.68 kg/ha) were recorded in 100% RDF. Similar results were observed with application of 200 kg lime/ha in mungbean. Interaction effect was also recorded at P=0.05 level of significance between fertility and lime levels on mungbean seed (622 kg/ha) and biological (2145kg/ha) yield with 100 % RDF + 200 kg lime/ha which were observed highest than all other treatments. Moreover, highest B:C ratio was observed with the application of 200 kg lime/ha. The present study revealed that soil acidity problems affecting pulses productivity, can be overcome with applications of 100% RDF and 200 kg lime/ha in Vindhyan region, India

Correlates of road traffic accident in cases attending IIR hospital Kanpur

Introduction: Globally, road traffic accidents rank 8th among the leading causes of death. According to WHO data, deaths from road traffic injuries account for around 25% of all deaths from injury. Objective: To study the various correlates of road traffic accident in cases attending LLR Hospital, Kanpur. Materials and Methods: The study was conducted among road traffic accident cases attending Emergency Ward of Lala Lajpat Rai Hospital, Kanpur, Uttar Pradesh during the period of March-September, 2015. Data was recorded in a pre-designed and pre-tested questionnaire and analyzed using SPSS software version 16.0. Results: Out of 609 RTA cases, maximum number (54.19%) were in 20-40 years age group. Most of the RTA victims were males (69.95%) and majority were literate (90.97%). Maximum number (28.74%) of RTA took place between 4.00 p.m-8.00 p.m. Maximum number (36.95%) of RTA victims were two-wheeler drivers, followed by two-wheeler riders (26.60%). 16.60% of drivers of motorized vehicles had no driving license. 85.48% of motorized vehicle users were not using any protective gear (helmet, seat belt etc.) at the time of accident. Conclusion: Young adults in the economically most productive age group were the commonest victims of RTA. There is need of creating awareness regarding traffic rules among general public and strict enforcement of traffic rules by the concerned authorities

Fiber-reinforced composites in endodontic practice: a review

Fiber-reinforced composites (FRCs) are a group of non-metallic biomaterials characterized by good mechanical properties, such as high fatigue resistance and fracture toughness growing in popularity in several dental applications. FRCs are a combination of two materials: the reinforcing phase in the form of fibers, which are embedded into the other material, called the matrix phase. Factors influencing the properties of FRCs include fibre properties versus polymer matrix properties, impregnation of fibres in the resin, adhesion of fibres to the polymer matrix, quantity and direction of fibres, and location of the fibre-rich phase in construction. The most commonly used applications of FRCs are in removable dentures, minimally invasive fixed dental prostheses, periodontal splints, root canal posts, and orthodontic retainers. This article discusses in detail the applications of FRCs in endodontics, including root canal posts, reinforcement of restorative composites in restorations and core build-ups and splinting of teeth in dental trauma

The Role of Hla Genes in Immune Response, Disease Susceptibility, and Social Behaviours: A Comprehensive Review

Major Histocompatibility Complexes (MHC), which assist to code for proteins that distinguish between self and non-self, are significantly influenced by the Human Leukocyte Antigen (HLA) genes. Particularly important in the suppression of immune response are the HLA genes. The bulk of the genes in the MHC region shows considerable variation. The two most important functions of HLA molecules are selection of T cell accumulation and the formation and control of immunological responses. The causes of HLA-G gene-associated illnesses and the underlying mechanisms are still up for dispute. The HLA-G gene has an impact on social behaviour as well. Numerous polymorphisms have been connected to heightened susceptibility to the beginning of autoimmune illnesses as well as heightened disease severity. The lifetime of some HLA genes is shorter.Genetic background, environmental circumstances, and certain polymorphisms have been linked to increased illness severity. certain HLA genes have shorter life spans than others, and vice versa. The major functional elements of HLA-G in both normal and autoimmune disorders are summarized in this study

Genetic Aspects of Implantation Failure

Implantation failure refers to the inability of a fertilized egg, or embryo, to successfully implant itself in the endometrial lining of the uterus, leading to pregnancy loss. The repeated failure of good quality embryo implantation is referred to as recurrent implantation failure (RIF). This can occur for a variety of reasons, including chromosomal abnormalities in the embryo, problems with the endometrium, or issues with the immune system. Factors such as advanced maternal age, obesity, smoking, and certain medical conditions can also increase the risk of implantation failure. While treatment such as in vitro fertilization (IVF) can help to improve the chances of successful implantation, there is currently no definite way to prevent or treat implantation failure.  Patients and healthcare professionals have substantial diagnostic and treatment hurdles as a result of many etiological factors and lack of knowledge about RIF. A number of studies have indicated a correlation between irregular hormone levels, disruptions in angiogenic and immunomodulatory factors, specific genetic polymorphisms, and the prevalence of RIF. Nonetheless, the precise and intricate underlying pathophysiology of RIF remains elusive.  However, many studies are ongoing in this field to understand the underlying causes and to find new ways to help couples achieve pregnancy. This review article extensively explores diverse molecular and genetic facets aimed at enhancing the diagnosis and management of implantation failure

Whole-Genome Sequence of Drug-Resistant Mycobacterium tuberculosis Strain S7, Isolated from a Patient with Pulmonary Tuberculosis

Over the past decades, drug-resistant Mycobacterium tuberculosis strains have presented a significant challenge, with inadequate diagnosis of tuberculosis (TB) cases. Here, we report the draft whole-genome sequence of drug-resistant M. tuberculosis strain S7, which was isolated from a patient from Tripura, India, who was diagnosed with pulmonary TB

Endocrine Autoimmunity in Association with Female Infertility

Infertility is the inability to conceive after a year of regular unprotected sexual intercourse, affecting 10-15% of couples. Advanced age, obesity, and certain medications can hinder fertility. Endocrine autoimmunity is increasingly recognized as a significant contributor to female infertility, often complicating various gynecological conditions. Autoimmune issues involving the hypothalamus, pituitary gland, thyroid, adrenal glands, and ovaries can impact fertility. A multidisciplinary approach is essential for diagnosing infertility, with a crucial focus on identifying potential endocrine disorders. Here we discuss how to identify endocrine autoimmune patients with ovulatory dysfunction. Women must be advised about limiting factors to be avoided, to protect their fertility. A comprehensive understanding of the underlying mechanisms, coupled with appropriate diagnostic and therapeutic approaches, is crucial for effectively managing this complex condition and helping women achieve their reproductive goals

Prospective Randomized Controlled Trial of Operative Rib Fixation in Traumatic Flail Chest

BACKGROUND: Traumatic flail chest injury is a potentially life threatening condition traditionally treated with invasive mechanical ventilation to splint the chest wall. Longer-term sequelae of pain, deformity, and physical restriction are well described. This study investigated the impact of operative fixation in these patients. STUDY DESIGN: A prospective randomized study compared operative fixation of fractured ribs in the flail segment with current best practice mechanical ventilator management. In-hospital data, 3-month follow-up review, spirometry and CT, and 6-month quality of life (Short Form-36) questionnaire were collected

Fabrication, Modeling and Characterization of Multi-Crosslinked Methacrylate Copolymeric Nanoparticles for Oral Drug Delivery

Nanotechnology remains the field to explore in the quest to enhance therapeutic efficacies of existing drugs. Fabrication of a methacrylate copolymer-lipid nanoparticulate (MCN) system was explored in this study for oral drug delivery of levodopa. The nanoparticles were fabricated employing multicrosslinking technology and characterized for particle size, zeta potential, morphology, structural modification, drug entrapment efficiency and in vitro drug release. Chemometric Computational (CC) modeling was conducted to deduce the mechanism of nanoparticle synthesis as well as to corroborate the experimental findings. The CC modeling deduced that the nanoparticles synthesis may have followed the mixed triangular formations or the mixed patterns. They were found to be hollow nanocapsules with a size ranging from 152 nm (methacrylate copolymer) to 321 nm (methacrylate copolymer blend) and a zeta potential range of 15.8–43.3 mV. The nanoparticles were directly compressible and it was found that the desired rate of drug release could be achieved by formulating the nanoparticles as a nanosuspension, and then directly compressing them into tablet matrices or incorporating the nanoparticles directly into polymer tablet matrices. However, sustained release of MCNs was achieved only when it was incorporated into a polymer matrix. The experimental results were well corroborated by the CC modeling. The developed technology may be potentially useful for the fabrication of multi-crosslinked polymer blend nanoparticles for oral drug delivery