High-sensitivity receiver for CO2 laser communications

Wideband heterodyne receiver provides detection and demodulation of incident frequency modulated laser signal; search and acquisition circuitry to align two stations; tracking circuitry to maintain spatial alignment; and laser frequency monitor to frequency lock the transmit and local oscillator lasers

Effect of feed supplementation with Origanum vulgare L. essential oil on sea bass (Dicentrarchus labrax): A preliminary framework on metabolic status and growth performances

This study provided a preliminary framework for the effects of Origanum vulgare L. essential oil (EO) on sea bass (Dicentrarchus labrax) health status over a 60-day feeding trial. Fish were fed twice a day until apparent satiety with three different diets: a control diet (CD), and two experimental diets supplemented with 100 (D100) and 200 (D200) ppm of oregano EO. No mortality was observed in each treatment. Feeding on D100 diet resulted in high growth performances and better food conversion and protein efficiency ratios. Additionally, the supplementation of 100 ppm EO diet also improved (P < 0.05) hepatosomatic and viscerosomatic indices, compared both to control and D200 diets. EO feeding positively affected (P < 0.05) several serum biochemical indices (amylase activity and total proteins, glucose, triglycerides, and cholesterol levels). Focusing on the antioxidant potential of blood, D100 led to the highest (P < 0.05) ferric reducing antioxidant power values and the lowest (P < 0.05) thiobarbituric acid-reactive substances levels in blood

A Fibre- vs. cereal grain-based diet: Which is better for horse welfare? Effects on intestinal permeability, muscle characteristics and oxidative status in horses reared for meat production

Horses reared for meat production are fed high amounts of cereal grains in comparison with horses raised for other purposes. Such feeding practice may lead to risk of poor welfare consequences. The aim of this study was to investigate the effects of two feeding practices on selected metabolic parameters and production aspects. Nineteen Bardigiano horses, 14.3 ± 0.7 months of age, were randomly assigned to two groups—one fed with high amounts of cereal grains (HCG; n = 9; 43% hay plus 57% cereal grain-based pelleted feed) vs. one fed with high amounts of fibre (HFG; n = 10; 70% hay plus 30% pelleted fibrous feed)—for 129 days. At slaught on abattoir, biological and tissue samples were collected to evaluate the microbiological contamination of mesenteric lymph nodes and liver; selected meat quality traits (chemical composition and fatty acid profile of the Longissimus thoracis et lumborum muscle); and the oxidative status of the horse. A linear mixed model was used: dietary treatment and sex were fixed effects and their interaction analysed on production and metabolic parameters as dependent variables. Results showed an increased intestinal permeability in the horses fed HCG compared to HFG, according to the significant increased total mesophilic aerobic bacteria counts in mesenteric lymph nodes (p = 0.04) and liver samples (p = 0.05). Horses in HCG showed increased muscle pH (p = 0.02), lighter muscle colour (L) (p = 0.01), increased intramuscular fat concentrations (p = 0.03), increased muscle glutathione peroxidase and superoxide dismutase activities (p = 0.01 and p = 0.03, respectively). Moreover, horses in HCG had lower muscle water holding capacity at interaction with sex (p = 0.03, lower in female), lower muscle protein content (p = 0.01), lower concentration of muscle PUFAs (p = 0.05) and lower plasma catalase activities (p = 0.05). Our results showed that feeding a high cereal grains diet can have global effects on horse physiology, and thus represents a threat for their welfare

Dietary supplementation of suckling lambs with anthocyanins: Effects on growth, carcass, oxidative and meat quality traits

The aim of this research was to assess the effect of the dietary inclusion in suckling lambs of a red orange and lemon extract rich in anthocyanins on growth performance, antioxidant status, carcass characteristics and of both dietary antioxidant addition and aging on meat fatty acids, colorimetric and antioxidant profile, and meat texture. The experiment was carried out using 44 Merino male lambs randomly assigned to two groups: one group received the red orange and lemon extract (RLE) (RLE; n = 22) and the control group (CON; n = 22) did not receive the anthocyanins. The RLE extract was orally administered (90 mg/kg of live weight) to each lamb every day from birth until slaughter (40 ± 1 days). Longissimus lumborum muscle was sampled and aged for 7 days. Rheological, colorimetric and oxidative parameters were affected by aging time and anthocyanins administration. The meat from RLE supplemented lambs had lower cooking loss and Warner-Blatzer Shear Force (WBSF) values. Moreover, thiobarbituric acid reactive substances (TBARS) and hydroperoxides were lower (P < 0.01) in RLE meat along the entire aging period, although in both groups they increased during aging (P < 0.01). The RLE addition affect yellowness values during aging, showing lower values in CON group at 7 d (P < 0.01). The RLE feed addition in able to positively affect oxidative animal status, and consequently animal welfare, enhancing meat oxidative stability and reducing colour deterioration during aging

ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation

Loss-of-function mutations of the skeletal muscle ClC-1 channel cause myotonia congenita with variable phenotypes. Using patch clamp we show that F484L, located in the conducting pore, probably induces mild dominant myotonia by right-shifting the slow gating of ClC-1 channel, without exerting a dominant-negative effect on the wild-type (WT) subunit. Molecular dynamics simulations suggest that F484L affects the slow gate by increasing the frequency and the stability of H-bond formation between E232 in helix F and Y578 in helix R. Three other myotonic ClC-1 mutations are shown to produce distinct effects on channel function: L198P shifts the slow gate to positive potentials, V640G reduces channel activity, while L628P displays a WT-like behaviour (electrophysiology data only). Our results provide novel insight into the molecular mechanisms underlying normal and altered ClC-1 function

Testbeam and Laboratory Characterization of CMS 3D Pixel Sensors

The pixel detector is the innermost tracking device in CMS, reconstructing interaction vertices and charged particle trajectories. The sensors located in the innermost layers of the pixel detector must be upgraded for the ten-fold increase in luminosity expected with the High- Luminosity LHC (HL-LHC) phase. As a possible replacement for planar sensors, 3D silicon technology is under consideration due to its good performance after high radiation fluence. In this paper, we report on pre- and post- irradiation measurements for CMS 3D pixel sensors with different electrode configurations. The effects of irradiation on electrical properties, charge collection efficiency, and position resolution of 3D sensors are discussed. Measurements of various test structures for monitoring the fabrication process and studying the bulk and surface properties, such as MOS capacitors, planar and gate-controlled diodes are also presented.Comment: 14 page

Viewpoint: Estimating the causal effects of policies and programs

Estimation, inference and interpretation of the causal effects of programs and policies have all advanced dramatically over the past 25 years. We highlight three particularly important intellectual trends: an improved appreciation of the substantive importance of heterogeneous responses and of their methodological implications, a stronger focus on internal validity brought about by the “credibility revolution,” and the scientific value that follows from grounding estimation and interpretation in economic theory. We discuss a menu of commonly employed partial equilibrium approaches to the identification of causal effects, emphasizing that the researcher’s central intellectual contribution always consists of making an explicit case for a specific causal interpretation given the relevant economic theory, the data, the institutional context and the economic question of interest. We also touch on the importance of general equilibrium effects and full cost–benefit analyses.RésuméPoint de vue: Sur l’estimation des effets causatifs des politiques et programmes. Dans le monde de l’estimation, l’inférence et l’interprétation des effets causatifs des programmes et des politiques, il y a eu des progrès dramatiques au cours des derniers 25 ans. Les auteurs soulignent trois tendances intellectuelles particulièrement importantes : une appréciation améliorée de l’importance substantielle des réponses hétérogènes et de leur importance méthodologique, une focalisation plus robuste sur la validité interne engendrée par la « révolution de la crédibilité », et la valeur scientifique qui découle d’un ancrage de l’estimation et de l’interprétation dans la théorie économique. On discute un éventail d’approches d’équilibre partiel à l’identification des effets causatifs, mettant au premier plan que la contribution intellectuelle centrale du chercheur consiste à bâtir un argumentaire explicite pour une interprétation causale spécifique compte tenu de la théorie économique pertinente, des données, du contexte institutionnel, et de la question économique d’intérêt. On mentionne aussi l’importance des effets d’équilibre général et des analyses de tous les coûts et avantages.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134884/1/caje12217.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134884/2/caje12217_am.pd