Heterologous booster COVID-19 vaccination elicited potent immune responses in HCWs

The objective of our study was to evaluate the antibody responses of health care workers (HCWs) who were vaccinated with booster dose BNT162b2 6 months after 2 doses of the CoronoVac vaccine. The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. In the sixth month after CoronaVac vaccination, the median of antibody levels of 1212.02 AU/ML, while it was 9283 AU/mL after BNT162b2 vaccination. IgG antibody titers of over 1050 AU/mL (which is equivalent to 1:80 dilution in the plaque reduction neutralization test) were detected in HCWs 15.09% and 97.8%, respectively. Our results showed that antibody titers increased 8-fold after the booster dose. We believe that the administration of the mRNA vaccine as a booster dose can provide more effective protection against COVID-19 infection, especially in individuals with risk factors.IU-Cerrahpaşa Scientific Research Projects Uni

Waning immunity to inactive SARS-CoV-2 vaccine in healthcare workers: Booster required

Aims Despite high vaccination rates, increasing case numbers continue to be reported with the identification of new variants of concern, and the issue of durability of the vaccine-induced immune response remains hot topic. Real-life data regarding time-dependent immunogenicity of inactivated COVID-19 vaccines are scarce. We aimed to investigate the changes in the antibody at the different times after the second dose of the CoronaVac vaccine. Methods The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. Chemiluminescent microparticle immunoassay (IgG II Quant test, Abbott, USA), which is 100% compatible with plaque reduction neutralization test, was used. Results Mean age of the participants was 38 +/- 11.23 years (range between 22 and 66) of whom 119 (63.9%) were female, and 56 (32%) were male. Dramatic reductions were demonstrated in median antibody levels particularly in the infection-naive group, comprising 138 HCWs compared to those with prior history of COVID-19 infection (n = 37) (p < 0.001). There was no difference between the two groups in terms of age, gender, blood groups, BMI, and comorbid diseases. Conclusions While antibody positivity remained above 90% in the 6th month after two doses of inactivated vaccine in HCWs, the median titers of neutralizing antibodies decreased rapidly. The decrease was more rapid and significant in those with no history of prior COVID-19 infection. In this critical phase of the pandemic, where we are facing the dominance of the Omicron variant after Delta, booster doses have become vital.IU-Cerrahpasa Scientific Research Projects Uni

TASL practice guidance on the clinical assessment and management of patients with nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD. This guidance was prepared following an interdisciplinary study under the leadership of the Turkish Association for the Study of the Liver (TASL), Fatty Liver Special Interest Group. This new TASL Guidance is a practical application guide on NAFLD and was prepared to standardize the clinical approach to diagnosing and treating NAFLD patients. This guidance reflects many advances in the field of NAFLD. The proposals in this guidance are meant to aid decision-making in clinical practice. The guidance is primar-ily intended for gastroenterology, endocrinology, metabolism diseases, cardi-ology, internal medicine, pediatric specialists, and family medicine specialists

Dunaliella salina teod. kültürü

Ekonomik öneme sahip olan algler son yıllarda teknolojik gelişmelerle birlikte tıp, gıda, eczacılık kozmetik gibi sanayi kolalrında kullanılmaktadır. Zengin algal beta-karoten ve gliserol kaynağı olarak kullnaılan Dunaliella salina; euryhalin bir organizma olması nedniyle de kültürü yapılıp ekonomik olarak değerlendirilmektedir. Bu tezde yüksek tuzkukuk ortamında üretilebilen ve bata karoten bakımından ticari bir kaynak olan Dunaliella salina'nın genel özellikleri ve yetiştiricilik için gerekli ortam koşulları anlatılmaktadır

Madde kullanım bozukuluğu olan kişilerde madde kullanım özellikleri üzerine nitel bir çalışma

This study was performed to determine the substance use features in people with substance use disorder; age of onset of substance use, factors triggering substance use, first substance used, other transition substances and reasons for choosing these substances, usage methods and problems caused by substance use. In-depth interviews were conducted with eight people diagnosed with substance use disorder in accordance with the objectives of the study. When the substance use features are examined; that the beginning of substance use is in the 15-18 age range, that is, adolescence is a risky period, substance use have triggers such as curiosity, friends, family and mental problems; the first use substance is cannabis and then because of curiosity, effect, friend recommendation, reliability, economic reasons use cocaine, ecstasy, bonsai, jamaica, pregabalin, bali, thinner, heroin, morphine; mostly bucket method is use to increase the effect; substance use has been found to cause many problems related to legal, familial-environmental, education and business life.Bu çalışma madde kullanım bozukluğu olan kişilerde madde kullanım özelliklerinin; madde kullanımına başlama yaşı, madde kullanımını tetikleyen faktörler, kullanılan ilk madde, diğer geçiş maddeleri ve bu maddeleri tercih etme sebepleri, kullanım şekilleri ve madde kullanımının sebep olduğu sorunların ortaya çıkartılması amacıyla yapılmıştır. Araştırmaya katılan madde kullanım bozukluğu tanısı almış sekiz kişiyle araştırmanın hedefleri doğrultusunda derinlemesine görüşmeler yapılmıştır. Madde kullanım özellikleri incelendiğinde; madde kullanımına başlamanın 15-18 yaş aralığında olduğu yani ergenlik döneminin riskli bir dönem olduğu, madde kullanımında; merak etme, arkadaş ortamı, ailesel ve ruhsal sorunlar gibi tetikleyicilerin olduğu, kullanıma esrar maddesiyle başlandığı ve sonrasında merak ve özenti, etkiyi arttırma, arkadaş tavsiyesi, daha güvenli bulma, ekonomik sebepler gibi nedenlerle kokain, ectasy, bonzai, jamaika, pregabalin, bali, tiner, eroin ve morfin maddelerinin kullanımının tercih edildiği, kullanım şeklinin etkiyi arttırmak amacıyla belirlendiği ve çoğunlukla bong-kova yönteminin kullanıldığı, madde kullanımının hukuksal, ailesel-çevresel, eğitim ve iş hayatıyla ilgili birçok soruna sebep olduğu bulunmuştur

Metástasis de adenocarcinoma de páncreas intramedular: Primer caso en la literatura

Background: Pancreatic cancer is a common gastrointestinal malignancy, and is often associated with a poor prognosis. Although liver is generally seen as a distant metastasis point, it has been shown that it can metastasize to any organ, especially the gastrointestinal tract, and approximately 0.3% of metastases are observed in spinal cord. Case description: We report a 36-year-old woman with a prior history of pancreatic adenocarcinoma who presented to us with a thoracic intramedullary lesion and recent onset of neurological deficits. She underwent surgery with histological confirmation of a diagnosis of metastatic adenocarcinoma. Conclusion: To our knowledge there is no prior report of pure intramedullary spinal cord metastasis from a pancreatic adenocarcinoma in the literature. We report the present patient in view of the rarity of intramedullary spinal cord metastasis and its clinical significance. Although intramedullary metastases are rare, they should be investigated in every patient with malignancy and progressive neurological deficit. While its general prognosis is poor regardless of the type of treatment, early diagnosis and treatment is important in terms of quality of life and survival.Antecedentes El cáncer de páncreas es una neoplasia maligna gastrointestinal común y, a menudo, se asocia con un mal pronóstico. Aunque el hígado generalmente se ve como un punto de metástasis distante, se ha demostrado que puede hacer metástasis a cualquier órgano, especialmente al tracto gastrointestinal, y aproximadamente el 0,3% de las metástasis se observan en la médula espinal. Descripción del caso Presentamos una mujer de 36 años con antecedentes de adenocarcinoma de páncreas que se presentó con una lesión intramedular torácica y de reciente aparición de déficits neurológicos. Fue intervenida quirúrgicamente con confirmación histológica de diagnóstico de adenocarcinoma metastásico. Conclusión Hasta donde sabemos, no existe en la literatura ningún informe previo de metástasis intramedular pura de la médula espinal de un adenocarcinoma pancreático. Presentamos el presente paciente en vista de la rareza de la metástasis intramedular de la médula espinal y su importancia clínica. Aunque las metástasis intramedulares son raras, deben investigarse en todo paciente con neoplasia maligna y déficit neurológico progresivo. Si bien su pronóstico general es malo independientemente del tipo de tratamiento, el diagnóstico y el tratamiento precoces son importantes en términos de calidad de vida y supervivencia