11 research outputs found
Innovative solid nanoparticles intended for oral, dermal and parenteral administration prepared by Nano Spray Dryer®
Processo one pot de sÃntese de nanocápsulas poliméricas, suas formas secas, composições farmacêuticas de nanocápsulas poliméricas e seus usos
Universidade Federal do Rio Grande do SulQuÃmicaFarmáciaDepositad
Processo one pot de sÃntese de nanocápsulas poliméricas, suas formas secas, composições farmacêuticas de nanocápsulas poliméricas e seus usos
Universidade Federal do Rio Grande do SulQuÃmicaFarmáciaDepositad
Impact of nanotechnology on public health : production of medicines
Several studies have described the benefits of nanoscience and nanotechnology (N&N) in different sectors such as agriculture, energy, environmental preservation, and public health. The rapid evolution of N&N can be shown through a panoramic analysis of scientific papers and patents. In the area of public health, it is estimated that the global market for nanotechnology products will expand to 160 billion U.S. dollars in 2015. The Brazilian government has also strengthened its innovative potential in N&N through economic subsidies, as observed for other countries. This review is focused on the current landscape of N&N in a therapeutic context, highlighting the development of nanotech-products produced with biocompatible and biodegradable materials that are already commercially available or under investigation. Most studies under investigation are focused on the development of nanotechnology-based formulations intended for treatment of cancer, inflammatory, cardiovascular, and neurological diseases. Although there are several advantages of N&N in healthcare, many challenges have to be conquered to increase the availability of nanotechnology products in toxicological, preclinical and clinical studies, scale-up, regulatory, and private investments
LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL) to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges of 10–1000 ng mL−1. Extraction recoveries, stability, and validation parameters were evaluated. Results were within the acceptable limits of international guidelines. A significant decrease in clearance led to a significant 2.26-times increase in AUC0–6h of olanzapine-loaded lipid-core nanocapsules compared with free-olanzapine
LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules
In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL) to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges of 10–1000 ng mL−1. Extraction recoveries, stability, and validation parameters were evaluated. Results were within the acceptable limits of international guidelines. A significant decrease in clearance led to a significant 2.26-times increase in AUC0–6h of olanzapine-loaded lipid-core nanocapsules compared with free-olanzapine
Gel termossensÃvel com nanocápsulas com indometacina como alternativa para capeamento pulpar : estudo preliminar
Formulation and characterization of poloxamer 407® : thermoreversible gel containing polymeric microparticles and hyaluronic acid
The influence of the composition and preparation method on the sol–gel transition temperature (Tsol–gel) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of Tsol–gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the Tsol–gel values. In contrast, the addition of microparticles caused a reduction in Tsol–gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds