17 research outputs found
Orthopaedic Disorders in Myotonic Dystrophy Type 1: descriptive clinical study of 21 patients
Thoracic cage plasticity in prepubertal New Zealand white rabbits submitted to T1-T12 dorsal arthrodesis: computed tomography evaluation, echocardiographic assessment and cardio-pulmonary measurements.
Purpose: We aimed to describe the morphological changes in the thoracic cage and spinal column induced in New Zealand White (NZW) prepubertal rabbits subjected to dorsal arthrodesis and observed at skeletal maturity by computed tomography (CT) scans. This was done to evaluate the plasticity of the thoracic cage of rabbits with non-deformed spine, by highlighting its modifications after spinal arthrodesis. Emogas data analysis, echocardiographic assessment and cardio-pulmonary measurements completed the evaluation. Methods: Surgery was performed in 16 female rabbits, 6 weeks old. Nine were subjected to T1-T12 dorsal arthrodesis, while seven were sham-operated. Surgery involved the implant of two C-shaped stainless steel bars and heterologous bone graft. CT scans were performed before surgery, 2, 6 and 12 months after surgery. One week after the last CT scan, echocardiographic and emogas evaluations were performed. Results: Chest depth (8 %), thoracic kyphosis (ThK) (23 %), dorsal and ventral length of the thoracic spine (11 %) and sternal length (7 %) were significantly reduced in operated compared to sham-operated rabbits. Mean values \ub1 standard deviation (SD) of PaCO2, PaO2 and sO2 were not significantly different. Mean values \ub1 SD of echocardiographic measurements were not significantly different between the two groups of rabbits, except for thickness of the interventricular septum in systole, contractile capacity of the left ventricle and ejection fraction. Conclusions: T1-T12 dorsal arthrodesis in prepubertal NZW rabbits with non-deformed spine induced changes of the thoracic cage morphology. However, those changes are source of cardio-pulmonary complications not severe enough to reproduce a clinical picture comparable to thoracic insufficiency syndrome in humans. \ua9 2013 Springer-Verlag Berlin Heidelberg
Dorsal arthrodesis of thoracicspine and effects on thorax growth in prepubertal new zealand white rabbits
Study Design. Dorsal arthrodesis of thoracic spine in a
prepubertal New Zealand White rabbit model.
Objective. Evaluating the consequences of dorsal arthrodesis
on the growth of the spine, sternum, and thorax
in prepubertal rabbits, through the study of CT scans.
Summary of Background Data. Vertebral arthrodesis
in the treatment of progressive idiopathic scoliosis in
prepubertal patients is not ideal, but is still a choice in
treating major deformities of the spine. Postoperative assessment
of spinal deformity is essential, feasible, and
recordable through CT scans.
Methods. Twelve female rabbits, 9 weeks old, were
subjected to surgery for dorsal arthrodesis of the upper
thoracic spine. Surgery involved the implant of 2 \u201cC\u201d-
shaped titanium bars, which were placed beside the spinous
processes of the thoracic vertebrae. Three CT scans
were performed, 10 (T1), 55 (T2), and 139 (T3) days after
surgery. Measures were obtained by Myrian Pro software
for 3 different groups: G1 with complete fusion, G2 with
incomplete fusion, and G3 sham-operated.
Results. The average of the dorsoventral/laterolateral
thoracic diameter ratio at fused levels is lower than 1 in G1
as well as in G2; on the contrary, in G3 is higher than 1. The
average growth of the sternum length between T1 and T2
and between T2 and T3 is minor in G1 than in G2 and G3.
The dorsal and ventral lengths of thoracic vertebral bodies
in the spinal segment D1-D6 is smaller in G1 and G2 than in
G3, whereas no differences were observed between the 3
groups in the D7-D12 segment without arthrodesis.
Conclusion. Dorsal arthrodesis in prepubertal rabbits
changes thoracic growth patterns. In operated rabbits, the
dorsoventral thoracic diameter grows more slowly than
the laterolateral thoracic diameter. The sternum as well as
the lengths of thoracic vertebral bodies in the spinal segment
D1-D6 grow less. The crankshaft phenomenon is
evident at the fused vertebral levels where there is a
reduction of thoracic kyphosis
Le taux de cortisol dans les poils comme possible marqueur bioclinique du stress : e'tude expe'rimental chez des lapines New Zealand White pre'-pubertaire
The growing spine: how spinal deformities influence normal spine and thoracic cage growth
Interrelations Between the Too-Long Anterior Calcaneal Process, Hind and Mid-tarsal Bone Volumes, Angles and Osteochondral Lesion of the Dome of the Talus: Analysis by Software Slicer of 69 CT Scan of Feet
International audienceIntroductionAlthough the association between Too-Long Anterior Calcaneal Process (TLACP) and osteochondral lesion of the dome of the talus (OCL) has been hypothesized, no study has investigated the interrelations between TLACP, hind and mid-tarsal volumes and angles and the development of OCL. The main goals of this work are: (1) to measure the volume of the calcaneum, talus, navicular and cuboid in subjects with and without TLACP; (2) to evaluate the angular relationships between talus, calcaneum and navicular in subjects with and without TLACP; (3) to assess whether TLACP has an effect on the volume of OCL.MethodsThis is a retrospective study of 69 CT scans of 54 consecutive children aged 11–15 years who had undergone a CT scan due to symptomatology suggestive of TLACP. The 3D Slicer software allowed to calculate the volume of the talus, calcaneum, navicular, cuboid, TLACP and OCL (in cm3). The PACS system was used to perform the angular measurements (in degrees) between talus, calcaneum and navicular in the frontal, axial and sagittal plane.ResultsAmid the 69 CT scans, 49 were found to have pathologies related to TLACP (71%, TLACP Group) and 20/69 were normal (29%, Control Group). The mean hind and mid-tarsal bone volumes of the TLACP group were comparable to those of the control group. There were 40 (81.6%) OCLs detected exclusively in pathological feet (TLACP group); 32 lesions were medial (80%), and 8 lesions were lateral (20%). According to Ferkel and Sgaglione CT Staging System, there were 22 (55%) stage 1 lesions, 5 (12.5%) stage 2A, 3 (7.5%) stage 2B and 10 (25%) stage three lesions. Only the angle between the talus and calcaneum in the frontal plane was significantly lower in pathological feet with respect to the control group (p < 0.001). In pathological feet, the talus was supinated, and the calcaneus pronated.ConclusionsTLACP tend to stiffen the foot, modifying its biomechanics and leading to supination of the talus and pronation of the calcaneum. This induces an overpressure at the medial side of the talus where we observed a greater frequency of medial OCL with larger volume than lateral OCL