Türk çocuklarında renkli görme bozukluklarının sıklık ve ağırlığının değerlendirilmesi

Objective: To determine the prevalence of color vision deficiency, ratio of deutan/protan and the distribution of the severity of color vision deficiency among Turkish children and to evaluate the usability the Color Assessment and Diagnosis (CAD) test in children. Material and Methods: A total of 1374 children (627 girls and 747 boys) of age 6-16 years were included in this study. The first 15 plates of the Ishihara test were used to evaluate to screen for color deficiency. Those who made three or more errors had their color vision examined using the CAD test to determine the type and severity of color vision deficiency. The prevalence of color vision deficiency in boys and girls, ratio of deutan and protan deficieny and the distribution of the severity of loss were calculated. The correlations of the CAD test result and number of mistakes on the Ishihara test with age were also evaluated. Results: Thirty seven boys (4.95%) and 3 girls (0.47%) made 3 or more errors and were categorized as having color vision deficiency. In total, 32 subjects completed the CAD test, 22 subjects (68.7%) were classified as deutan and 10 (31.2%) as protan with the ratio of 2.2:1. In terms of the CAD based color vision grading system for red-green deficiency 3 subjects (9.3%) were classed as color vision (CV) category 3, 5 subjects (15.6%) as CV category 4 and 24 subjects (75%) as CV category 5. There was no significant correlation between the CAD test result and number of mistakes on the Ishihara test with age (r=-0.075, p=0.684 and r=-0.191, p=0.295 respectively). Conclusion: The results reveal severe loss of red-green color vision in 75% of the children with color vision deficiency. The study also demonstrates that the CAD test can be used in children as young as six years.Amaç: Türk çocuklarında renkli görme bozukluğunun prevalansı, dötan/protan oranı ve ağırlığına göre renkli görme bozukluğunun dağılımının saptanması ve Renk Değerlendirme ve Tanı testinin çocuklarda kullanılabilirliğini değerlendirmektir. Gereç ve Yöntemler: Yaşları 6 ile 16 arasında değişen 627'si kız 747'si erkek toplam 1374 çocuk çalışmaya dahil edildi. Renkli görme bozukluğunun taranmasında İshihara testinin ilk 15 plakası kullanıldı. Üç ve üzerinde hata yapanlar renkli görme bozukluğunun tipi ve ağırlığının tespit edilebilmesi için Renk Değerlendirme ve Tanı testi ile değerlendirildi. Kızlarda ve erkeklerdeki renkli görme bozukluğunun prevalansı, dötan/protan oranı ve ağırlığına göre renkli görme bozukluğunun dağılımı hesaplandı. Renk Değerlendirme ve Tanı testinin sonuçları ile İshihara testindeki hata sayısının yaş ile olan korelasyonu da değerlendirildi. Bulgular: İshihara testinde 3 ve üzerinde hata yapan 37 erkek (%4,95) ve 3 kız (%0,47) renkli görme bozukluğu olanlar grubunda değerlendirildi. Olgulardan 32 tanesi Renk Değerlendirme ve Tanı testini tamamlayabildi. Bu olgulardan 22 tanesi (%68,7) dötan, 10 tanesi (%31,2) protandı ve dötan/protan oranı 2,2:1 idi. Renk Değerlendirme ve Tanı testinin kırmızı- yeşil renkli görme bozukluğu ağırlık sınıflandırmasına göre olgulardan 3'ü (%9,3) renkli görme kategori 3, 5'i (%15,6) kategori 4 ve 24'ü (%75) kategori 5'e dahildi. Renk Değerlendirme ve Tanı testinin sonucu ve İshihara testindeki hata sayısı ile yaş arasında korelasyon tespit edilmedi (r=-0,075, p=0,684 ve r=-0,191, p=0,295 sırasıyla). Sonuç: Sonuçlar renkli görme bozukluğu olan çocukların %75'inin ağır kırmızı-yeşil renkli görme bozukluğuna sahip olduğunu göstermektedir. Çalışma aynı zamanda Renk Değerlendirme ve Tanı testi'nin çocuklarda 6 yaşından itibaren kullanılabilir olduğunu göstermektedir

Evaluation of stereopsis in children with corrected anisometropia according to type, severity, and presence of amblyopia

Objective: This study was designed to determine the level of stereopsis in anisometropic children with and without amblyopia who used corrective glasses and to investigate the effect of the type and magnitude of anisometropia on the level of stereopsis. Materials and Methods: The medical records of 256 children with a diagnosis of non-amblyopic anisometropia or anisometropic amblyopia, and healthy controls were retrospectively reviewed for this study. Anisometropia was categorized into 3 groups: spherical equivalent-only anisometropia, astigmatic-only anisometropia, or combined anisometropia. The level of stereopsis was measured using the Titmus stereo test, compared between groups, and the correlation of the stereopsis with the magnitude of anisometropia was analyzed. Results: Patients in the non-amblyopic anisometropia group had a similar stereopsis level when compared with the control group (55.2 +/- 41.03 and 47.2 +/- 19.8 seconds of arc, respectively; p=0.223). The level of stereopsis was significantly less in the anisometropic amblyopia group (279.4 +/- 120 seconds of arc) compared with the non-amblyopic anisometropia (55.2 +/- 41.03 seconds of arc) and control groups (47.2 +/- 19.8 seconds of arc) (p=0.008, p=0.006, respectively). A greater spherical equivalent difference between the eyes resulted in poorer stereopsis in the anisometropic amblyopia group, and combined anisometropia was found to be associated with poorer stereopsis levels in the nonamblyopic anisometropia (NA) group. Conclusion: The NA patients had a similar level of stereopsis compared with controls while wearing corrective glasses. This result suggests that as long as patients have good visual acuity, stereopsis is preserved, and that refractive correction with glasses does not interfere with stereopsis in childhood anisometropia

Corneal Endothelial Cell Density and Morphology in Healthy Turkish Eyes

Purpose. To describe the normative values of corneal endothelial cell density, morphology, and central corneal thickness in healthy Turkish eyes. Methods. Specular microscopy was performed in 252 eyes of 126 healthy volunteers (M : F, 42 : 84). Parameters studied included mean endothelial cell density (MCD), mean cell area (MCA), coefficient of variation (CV) in cell size, percentage of hexagonal cells, and central corneal thickness (CCT). Results. The mean age of volunteers was 44.3±13.5 (range, 20 to 70) years. There was a statistically significant decrease in MCD (P<0.001; correlation, −0.388) and percentage of hexagonal cells, (P<0.001; correlation, −0.199) with age. There was also a statistically significant increase in MCA (P<0.001; correlation, 0.363) with increasing age. There was no statistically significant difference in MCD, MCA, CV in cell size, percentage of hexagonal cells, and CCT between genders and there was also no significant difference in these parameters between fellow eyes of subjects. Conclusions. Normotive data for the endothelium in the Turkish population are reported. Endothelial cell density in the Turkish eyes is less than that described in the Japanese, American, Chinese, and Filipino eyes and higher than that described in Indian, Thai, and Iranian eyes

Açık açılı glokom tedavisinde ab interno jel implant kısa dönem sonuçlarının retrospektif incelenmesi

Aim: To evaluate the intraocular pressure (IOP) lowering and safety profiles of the Xen45 Gel Stent implantation with preoperative Mitomycin C injection during a 6 months follow-up in patients with primary open-angle glaucoma (POAG). Material and Methods: Records of fourteen eyes of 13 POAG patients who underwent surgery with XEN45 Gel Stent combined with phacoemulsification were evaluated retrospectively. IOP changes, all complications and additional procedures during follow-up period were evaluated. Primary outcome measure was IOP, and the IOP target for complete success was defined as a postoperative IOP drop of more than 20% from preoperative baseline and IOP≥6 and ≤21 at 6 months without any glaucoma medications and qualified success was defined as a postoperative IOP reduction of more than 20% and IOP≥6 and ≤21 at 6 months with or without medications. Results: Mean preoperative medicated IOP was 28.4 ± 2.7 mmHg with a mean of 2.6 ± 0.6 topical anti- glaucoma molecules. After 6 month follow-up period, mean IOP decreased to 17.8 ± 1.5 mmHg (mean IOP reduction of 37%) on 0.4 ± 1.1 antiglaucoma molecules. The complete success rate after 6 months was achieved in 42.8% and qualified success in 85.7. Totally only 2 (14.2%) patients required additional procedure (1 needling and 1 trabeculectomy). Conclusion: The study showed that the XEN45 Gel Stent implantation combined with phaco-cataract surgery is an effective surgical method in POAG in case of uncontrolled IOP with a favorable safety profile and low complication rate.Amaç: Primer açık açılı glokom (PAAG) hastalarında 6 aylık takip sırasında preoperatif Mitomycin C enjeksiyonu ile Xen45 Jel Stent implantasyonunun göz içi basıncını(GİB) düşürme ve güvenlik profillerini değerlendirmek. Gereç ve Yöntemler: Fakoemülsifikasyon ile kombine XEN45 Jel Stent ile ameliyat edilen 13 PAAG hastasının 14 gözünün kayıtları retrospektif olarak değerlendirildi. Takip süresince GİB değişiklikleri, tüm komplikasyonlar ve ek işlemler değerlendirildi. Çalışmada birincil değerlendirilen sonuç GİB idi. Tam başarı için belirlenen GİB hedefi ameliyat öncesine göre %20’nin üzerinde bir düşüş ve herhangi bir glokom ilacı olmaksızın 6. ayda GİB≥6 ve ≤21 olarak tanımlandı. Yeterli başarı ise ilaçlı veya ilaçsız olarak 6. ayda GİB’de %20’den fazla azalma ve GİB≥6 ve ≤21 olarak tanımlandı. Bulgular: Ortalama preoperatif ilaçlı GİB, ortalama 2,6 ± 0,6 topikal anti-glokom molekülü ile beraber 28,4 ± 2,7 mmHg idi. Altı aylık takip süresinden sonra ortalama GİB, 0,4 ± 1,1 anti-glokom molekülü ile beraber 17,8 ± 1,5 mmHg’ye (ortalama GİB düşüşü %37) düştü. 6 ay sonra tam başarı oranı %42,8 ve yeterli başarı oranı %85,7 olarak bulundu. Toplamda sadece 2 hastaya (%14,2) ek işlem (1 iğneleme ve 1 trabekülektomi) gerekti. Sonuç: Çalışma, fako-katarakt cerrahisi ile kombine XEN45 Jel Stent implantasyonunun, kontrolsüz GİB durumunda olumlu güvenlik profili ve düşük komplikasyon oranı ile PAAG’da etkili bir cerrahi yöntem olabileceğini göstermiştir

Experimental laboratory modeling of choroidal vasculature: A study of the dynamics of intraoperative choroidal hemorrhage during pars plana vitrectomy

Amaç: Koroid kanamaları (KK), koroid damarlarının rüptürü ve kanın supra koroid boşluğuna ekstravazasyonu ile meydana gelir. Koroid damar sistemini daha iyi şekilde anlamak için, bu çalışmada amaca yönelik olarak ölçeklendirilmiş bir model kullanıldı. Bu model aracılığıyla, koroid damar sistemindeki stres düzeyleri farklı koşullar altında ölçüldü. Gereç ve Yöntem: Koroid damar yapısı modelinde, 1 cm genişliğinde ve 10 cm uzunluğunda lastik bir tüp kullanıldı. Modeldeki stres seviye ölçümü için ise özel iletken iplik kullanıldı. Modeldeki stres seviyeleri, farklı sistemik intravasküler kan basıncı seviyeleri (İVB), farklı göz içi basınç seviyeleri (GİB) ve farklı distorsiyon seviyeleri altında ölçüldü. Bulgular: Koroid damar modelindeki stres değerleri GİB ile negatif, İVB ve distorsiyon ile pozitif korelasyon gösterdi. Tüm korelasyonlar istatistiksel olarak anlamlı idi (p<0,05). Ancak, modelde ekspansil tamponad kullanıldığında bu korelasyon ekspansil olmayan tamponadlara göre daha kuvvetliydi. Distorsiyonun stres ile korelasyonu, İVB’nin korelasonuna göre daha güçlü idi. İVB’nin stres ile korelasyonu ise, GİB’nin korelasonuna göre daha güçlü idi. Distorsiyondan kaynaklanan damar yapısındaki stres, yüksek GİB etkisi ile karşılaştırıldığında gerileme gösterirken, yüksek İVB’den kaynaklanan damar yapısındaki stres tam tersine hafif bir artış sergiledi. Sonuç: Cerrahi işlemler sırasında göz küresinin aşırı distorsiyonu, nadiren görülen intraoperatif KK’lerin başlıca nedeni olabilir. Ekspansil olmayan oküler tamponat kullanımı, koroid kanamasına karşı vasküler yatak için daha iyi destek sağlar ve koroid kanaması saptanan hastalarda önerilen tampon çeşidi olmalıdır. GİB’nin aşırı artırılması, distorsiyondan kaynaklanan koroid damarlarındaki kanama riskinin önlenmesinde sınırlı etkiye sahiptir.Objectives: Choroidal hemorrhages (CH) result from rupture of choroidal vessels leading to extravasation of blood into the suprachoroidal space. In this study, we aimed to understand the hemodynamics of CH by developing a purpose-built scale model of the choroidal vasculature and calculating stress levels in the model under different conditions. Materials and Methods: We modeled the choroidal vasculature using a rubber tube 10 cm in length and 1 cm in diameter that was wrapped with conductive thread to enable the measurement of stress at the walls of the tube. Stress levels across the tube were continuously measured under different systemic intravascular blood pressure levels (IVP), intraocular pressure (IOP) levels, and distortion. Results: Stress values across the choroidal vessel model correlated negatively with IOP and positively with IVP and distortion. All correlations were statistically significant (p<0.05) and were stronger when the model was filled with expansile tamponade compared to non-expansile tamponades. Distortion showed the strongest correlation in terms of increasing stress across the model, while IVP showed stronger correlation compared to IOP. Raising IOP to counteract the stress in the model was effective when the stress in the model was secondary to increased IVP, but this approach was not effective when the stress in the model was caused by distortion. Conclusion: Excessive distortion of the globe during surgical maneuvers could be the primary reason for the rarely observed intraoperative CH. Non-expansile ocular tamponade provides better support for the vascular bed against CH and should be the recommended choice of tamponade in patients with existing CH. Increasing IOP excessively is of limited effect in preventing CH in vessels that are under stress as a result of distorting surgical maneuvers

Üç farklı speküler mikroskopi cihazı ile ölçülen korneal endotel parametrelerinin karşılaştırılması: Karşılaştırmalı klinik çalışma

ABS TRACT Objective: The present study aimed to compare the Nidek CEM-530 (Nidek Co., Japan), Konan CellChek XL (Konan Medical, Hyogo, Japan), and Topcon SP-3000P (Topcon Corporation, Tokyo, Japan) noncontact specular microscopes (NCSM) in terms of endothelial cell density (ECD), morphological endothelial cell parameters, and central corneal thickness (CCT), in healthy subjects. Material and Methods: Right eyes of 49 patients were included in this study. ECD, CCT, average cell area, coefficient of variation, standard deviation of cell area, cell hexagonality ratio were evaluated with Nidek CEM-530, Topcon SP-3000P and The CellChek XL NCSMs. Results: The mean age was 36.2±9.6 years. The mean ECD was 2809±24.1, 2626±50.4, and 2588±32.1 in measurements with Konan CellCheck XL, Topcon SP-3000P, and Nidek CEM-530 NCSMs, respectively. The difference was statistically significant between Konan CellCheck XL with Nidek CEM-530 and Topcon SP-3000P (p<0.001 for both). The hexagonality ratio results between these 3 devices were statisti cally significant in all paired comparisons (p<0.001, for all). The mean CCT was 534.4±5.0, 553.9±5.6, 567.5±5.3 in measurements with Nidek CEM-530, Konan CellCheck XL, and Topcon SP-3000P, respectively. CCT values obtained with Topcon SP-3000P were found to be higher than with other devices (p<0.001, for both). Conclusion: Among the 3 devices, the highest ECD values were obtained with Konan CellCheck XL and the highest CCT values were obtained with Topcon SP-3000P. On account of the discrepancies in endothelial pa rameters tested in our study, we do not advise using these devices in terchangeably.Amaç: Bu çalışmada, sağlıklı kişilerde Nidek CEM-530 (Nidek Co., Japonya), Konan CellChek XL (Konan Medical, Hyogo, Japonya) ve Topcon SP-3000P (Topcon Corporation, Tokyo, Japonya) temassız speküler mikroskopların [noncontact specular microscopes (NCSM)] endotel hücre yoğunluğu (EHY), morfolojik endotel hücre parametre leri ve santral kornea kalınlığı (SKK) açısından karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmaya, 49 hastanın sağ gözü dâhil edildi. EHY, SKK, ortalama hücre alanı, varyasyon katsayısı, hücre alanının standart sapması, hekzagonal hücre oranı, Nidek CEM530, Topcon SP-3000P ve CellChek XL temassız speküler mikroskop cihazları incelendi. Bulgular: Ortalama yaş 36,2±9,6 yıl idi. Konan CellCheck XL, Topcon SP-3000P ve Nidek CEM-530 NCSM’lerle yapılan ölçümlerde ortalama EHY sırasıyla 2809±24,1, 2626±50,4 ve 2588±32,1 idi. Konan CellCheck XL ile Nidek CEM-530 ve Topcon SP-3000P ölçümleri arasındaki fark istatistiksel olarak anlamlıydı (her ikisi için p<0,001). Bu 3 cihaz arasındaki hekzagonal hücre oranı sonuçları, tüm ikili karşılaştırmalarda istatistiksel olarak anlamlıydı (tümü için p<0,001). Nidek CEM-530, Konan CellCheck XL ve Topcon SP-3000P ölçümlerinde ortalama SKK sırasıyla 534,4±5,0, 553,9±5,6, 567,5±5,3 idi. Topcon SP-3000P ile elde edilen SKK değerleri diğer cihazlara göre daha yüksek bulundu (her ikisi için p<0,001). Sonuç: Üç cihaz arasında en yüksek EHY değerleri Konan CellCheck XL ile, en yüksek SKK değerleri ise Topcon SP-3000P ile elde edildi. Çalışmamızda test edilen endotelyal parametrelerdeki farklılıklar nedeniyle bu cihazların birbirinin yerine kullanılmasını önermiyoruz

Comparison of optical coherence tomography measurements between high hyperopic and low hyperopic children

Purpose: To identify the peripapillary retinal nerve fiber layer, total macular, ganglion celllayer, and inner plexiform layer thicknesses in children with high hyperopia using spectraldomain optical coherence tomography.Methods: Twenty-one children with high hyperopia and 20 controls were enrolled in thisstudy. Subjects with spherical equivalent +5.0D or higher were evaluated in the study groupand subject with spherical equivalent between +0.25 and +2.0 D in the control group. Theretinal nerve fiber layer thickness, macular thickness, macular ganglion cell layer and innerplexiform layer thicknesses were measured using a spectral domain optical coherencetomography, and results were compared between groups.Results: The nasal and inferior quadrant and the global retinal nerve fiber layer thicknesswere significantly thicker in the study group. The mean thickness of inferior quadrant of theinner macula was significantly thicker in the study group than those in the control group.The mean thickness of the ganglion cell layer in nasal, temporal and inferior quadrant ofouter macula was significantly thinner in the study group than the control group. The meanthickness of the inner plexiform layer in the inferior quadrant of the inner macula and nasaland inferior quadrant of the outer macula were significantly higher in study group than thosein control group.Conclusion: High hyperopic children had thicker retinal nerve fiber layer when comparedto the controls. This difference should be taken into account when evaluating children withglaucoma or other optic disc disorders

Comparison of the plusOptix S09 and spot vision photorefractor to cycloretinoscopy

Purpose: The purpose of this study was to compare refraction measurements for children with the PlusOptix S09 and Spot Vision with cycloplegic retinoscopy. Methods: One hundred thirty-six eyes of 68 children (26 boys and 42 girls) were evaluated prospectively. The subjects were separated into two groups. Group 1 comprised the subjects age between 5 and 9 years. Group 2 comprised the subjects age between 10 and 18 years. Photorefraction with PlusOptix S09, photorefraction with Spot Vision and cycloplegic retinoscopy were performed in each patient. Spherical equivalents, spherical power, cylindrical power and axis values were compared between three methods. Results: The mean age of the patients was 7.12 ± 1.5 years in group 1 and 12.24 ± 1.8 years in group 2. Spherical equivalent and spherical power measured with PlusOptix S09 were statistically smaller than measured with cycloplegic retinoscopy for group 1 (p = 0.001, p = 0.001) and for group 2 (p = 0.000, p = 0.000). The mean cylindrical power measured with PlusOptix S09 was not statistically different compared to cycloplegic retinoscopy for both groups (p = 0.314, p = 0.05). Spherical equivalents measured with Spot Vision were statistically smaller than measured with cycloplegic retinoscopy for both groups (p = 0.000, p = 0.012). Spherical power measured with Spot Vision was statistically smaller than measured with cycloplegic retinoscopy for group 1 (p = 0.000), but the difference was not statistically significant for group 2 (p = 0.084). The mean cylindrical power measured with Spot Vision was statistically higher than cycloplegic retinoscopy for both groups (p = 0.000, p = 0.012). Conclusions: PlusOptix S09 and Spot Vision devices give acceptable results for screening, but prescription of spectacles should not be made according to PlusOptix S09 or Spot Vision devices alone

Experimental laboratory modeling of choroidal vasculature: A study of the dynamics of intraoperative choroidal hemorrhage during pars plana vitrectomy

Objectives: Choroidal hemorrhages (CH) result from rupture of choroidal vessels leading to extravasation of blood into the suprachoroidal space. In this study, we aimed to understand the hemodynamics of CH by developing a purpose-built scale model of the choroidal vasculature and calculating stress levels in the model under different conditions. Materials and Methods: We modeled the choroidal vasculature using a rubber tube 10 cm in length and 1 cm in diameter that was wrapped with conductive thread to enable the measurement of stress at the walls of the tube. Stress levels across the tube were continuously measured under different systemic intravascular blood pressure levels (IVP), intraocular pressure (IOP) levels, and distortion. Results: Stress values across the choroidal vessel model correlated negatively with IOP and positively with IVP and distortion. All correlations were statistically significant (p<0.05) and were stronger when the model was filled with expansile tamponade compared to non-expansile tamponades. Distortion showed the strongest correlation in terms of increasing stress across the model, while IVP showed stronger correlation compared to IOP. Raising IOP to counteract the stress in the model was effective when the stress in the model was secondary to increased IVP, but this approach was not effective when the stress in the model was caused by distortion. Conclusion: Excessive distortion of the globe during surgical maneuvers could be the primary reason for the rarely observed intraoperative CH. Non-expansile ocular tamponade provides better support for the vascular bed against CH and should be the recommended choice of tamponade in patients with existing CH. Increasing IOP excessively is of limited effect in preventing CH in vessels that are under stress as a result of distorting surgical maneuvers

Retinal nerve fiber layer analysis in obstructive sleep apnea

Amaç: Obstrüktif uyku apne sendromu (OUAS) hastalarını retina sinir lifi tabakası (RSLT) kalınlıkları yönünden incelemek ve oküler değişikliklerin hastalığın şiddeti ile ilişkisini belirlemek. Gereç ve Yöntem: OUAS tanılı 54 hasta göz bulguları açısından değerlendirildi. Respiratory Disturbance Index-Anormal Solunum Olayı İndeksi (RDI) 5-29 olan 21’i grup 1, RDI>29 olan 33’ü ise grup 2 kapsamında sınıflandırıldı. Hastalara Optik Koherens Tomografi (OKT) ile RSLT ölçümleri yapıldı. Gruplar elde edilen veriler açısından karşılaştırılırken, verilerin RDI, ortalama ve minimum O2 satürasyonu ile olan ilişkileri de incelendi. Bulgular: Ortalama RSLT grup 1’de 117,33±7,57 μm, grup 2’de ise 111,91 ±8,64 μm olarak ölçüldü. RSLT’deki incelme istatistiksel olarak anlamlı bulundu (p=0,023). İnferior RSLT grup 1’de 147,95 ±12,97 μm, grup 2’de 137,27±17,94 μm olarak bulundu. Grup 2’deki incelme istatistiksel olarak anlamlı bulundu (p=0,032). Ortalama RSLT ile RDI arasında negatif korelasyon saptandı . Sonuç: OUAS hastalarında RSLT kalınlığında azalma meydana gelmekte ve bu değişimler OUAS’ın ağırlığı ile korelasyon göstermektedir. Bu iki durum arasındaki ilişkinin bilinmesi hastaların öncelikle göz hekimi tarafından görüldüklerinde olası OUAS semptomları yönünden sorgulanmalarına olanak sağlayacaktır.Objective: To investigate the retinal nerve fiber thickness (RNFL) in patients with Obstructive sleep apnea syndrome (OSAS) and to determine the correlation of ocular changes with the severity of disease. Material and Methods: 21 patients with Respiratory Disturbance Index (RDI) between 5-29 were included in group 1 and 33 patients with RDI > 29 in group 2. Patients received RNFL measurement with optical coherence tomography (OCT). The difference between the groups and the correlation of RFNL with RDI, mean and minimum O2 saturation was evaluated. Results: The mean RNFL was 117.33±7.57 in group 1, 111.91 ±8.64 μm in group2. There was statistically significant difference (p=0.023). RNFL in inferior quadrant was 147.95 ±12.97 for group 1, 137.27±17.94 μm for group 2. The difference was statistically significant (p=0.032). Mean RNFL was correlated with RDI. Conclusion: There is a significant decreare in RFNL occur in patients with OSAS and changes show correlation with severity of disease. Awareness of relationship helps ophthalmologists to question their patients in terms of OSAS symptoms