Classification of Static, Spherically Symmetric Solutions of the Einstein-Yang-Mills Theory with Positive Cosmological Constant

We give a complete classification of all static, spherically symmetric solutions of the SU(2) Einstein-Yang-Mills theory with a positive cosmological constant. Our classification proceeds in two steps. We first extend solutions of the radial field equations to their maximal interval of existence. In a second step we determine the Carter-Penrose diagrams of all 4-dimensional space-times constructible from such radial pieces. Based on numerical studies we sketch a complete phase space picture of all solutions with a regular origin.Comment: 49 pages, 19 figures, submitted to Commun. Math. Phy

On Nonlinear σ\sigma-Models arizing in (Super-)Gravity

In a previous paper with Gibbons [CMP 120 (1987) 295] we derived a list of three dimensional symmetric space $\sigma$-model obtained by dimensional reduction of a class of four dimensional gravity theories with abelian gauge fields and scalars. Here we give a detailed analysis of their group theoretical structure leading to an abstract parametrization in terms of `triangular' group elements. This allows for a uniform treatment of all these models. As an interesting application we give a simple derivation of a `Quadratic Mass Formula' for strictly stationary black holes.Comment: 33 pages, 1 tabl

Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae"

The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown. Recently, we identified Rrp8 as a methyltransferase involved in m1A645 modification of 25S rRNA. Here, we discovered a previously uncharacterized gene YBR141C to be responsible for second m1A2142 modification of helix 65 of 25S rRNA. The gene was identified by reversed phase–HPLC screening of all deletion mutants of putative RNA methyltransferase and was confirmed by gene complementation and phenotypic characterization. Because of the function of its encoded protein, YBR141C was named BMT2 (base methyltransferase of 25S RNA). Helix 65 belongs to domain IV, which accounts for most of the intersubunit surface of the large subunit. The 3D structure prediction of Bmt2 supported it to be an Ado Met methyltransferase belonging to Rossmann fold superfamily. In addition, we demonstrated that the substitution of G180R in the S-adenosyl-l-methionine–binding motif drastically reduces the catalytic function of the protein in vivo. Furthermore, we analysed the significance of m1A2142 modification in ribosome synthesis and translation. Intriguingly, the loss of m1A2142 modification confers anisomycin and peroxide sensitivity to the cells. Our results underline the importance of RNA modifications in cellular physiology

First results in QCD with 2+1 light flavors using the fixed-point action

This is a progress report on 2+1 flavor simulation with the FP action on a lattice with spatial size L=1.2fm. Since m_{ud} is quite small in our simulation we are in the delta regime for the two light flavors where the low lying excitations are described by a quantum mechanical rotator. From here we extract the low energy constant F. We also measure the AWI mass and present results on numerical issues like low-mode averaging and autocorrelation times.Comment: 7 pages, 6 figures, parallel talk at LATTICE 200

Transcriptional regulation of prostate kallikrein-like genes by androgen.

Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied. Prostate-specific antigen (PSA) and human glandular kallikrein (hGK-1) together constitute a subfamily of serine proteases exclusively produced in the human prostate. RNA analysis revealed that both genes are expressed in LNCaP cells with PSA basal levels being 2-fold higher than hGK-1 levels. Both mRNAs are induced over a period of 24 h in the presence of 3.3 nM of the synthetic androgen mibolerone. Stimulation of PSA RNA is about 5- fold,whereas hGK-1 stimulation is less pronounced. Nuclear run-on analysis revealed that androgen induction of kallikrein-like genes in LNCaP cells is a rapid event (c3 h) occurring at the level of transcription initiation. Treatment of cells with cycloheximide demonstrates that, while PSA/hGK-1 basal transcription strictly depends on continuous protein synthesis, transcriptional induction by androgen does not. This suggests the direct involvement of the androgen receptor in the induction process independent of additional labile protein factors necessary for kallikrein basal transcription. A binding motif is present in the PSA and hGK-1 promoters, closely resembling the consensus sequence for steroidresponsive elements. The androgen antagonist cyproterone acetate was also able to stimulate transcription of kallikrein-like genes in LNCaP cells. In contrast, androgen-dependent transcriptional suppression of the protooncogene c-myc was strongly counteracted by cyproterone acetate. Thus, antiandrogens act differentially on androgen-regulated prostate-specific (PSA, hGK-1) and growthrelated (c-myc) gene expression in LNCaP cells