30 research outputs found
Statistical Inference in a Directed Network Model with Covariates
Networks are often characterized by node heterogeneity for which nodes
exhibit different degrees of interaction and link homophily for which nodes
sharing common features tend to associate with each other. In this paper, we
propose a new directed network model to capture the former via node-specific
parametrization and the latter by incorporating covariates. In particular, this
model quantifies the extent of heterogeneity in terms of outgoingness and
incomingness of each node by different parameters, thus allowing the number of
heterogeneity parameters to be twice the number of nodes. We study the maximum
likelihood estimation of the model and establish the uniform consistency and
asymptotic normality of the resulting estimators. Numerical studies demonstrate
our theoretical findings and a data analysis confirms the usefulness of our
model.Comment: 29 pages. minor revisio
Mapping Molecular Orientation with Phase Sensitive Vibrationally Resonant Sum-Frequency Generation Microscopy
We demonstrate a phase sensitive, vibrationally resonant sum-frequency generation (PSVR-SFG) microscope that combines high resolution, fast image acquisition speed, chemical selectivity, and phase sensitivity. Using the PSVR-SFG microscope, we generate amplitude and phase images of the second-order susceptibility of collagen I fibers in rat tail tendon tissue on resonance with the methylene vibrations of the protein. We find that the phase of the second-order susceptibility shows dependence on the effective polarity of the fibril bundles, revealing fibrous collagen domains of opposite orientations within the tissue. The presence of collagen microdomains in tendon tissue may have implications for the interpretation of the mechanical properties of the tissue. [Image: see text