Identifying the need to discuss infertility concerns affecting testicular cancer patients: an evaluation (INDICATE study)

Simple SummaryTesticular cancer is the most common malignancy in young males affecting the ability to father children. It's important that effects on fertility are discussed before starting treatment so patients are aware of the risks and their options. The objective of our study was to evaluate the manner in which men with testicular cancer are counselled about implications on fertility and the possibility of semen preservation. Furthermore, we aimed to evaluate satisfaction with provided information and to identify reproductive concerns. In a sample of 201 patients, one out of ten patients reported not to be informed about the risk of subfertility. Sperm banking was performed by 41.3%, of which 13 men made use of preserved sperm, resulting in paternity for 7 men. The subjects fertility and semen preservation need to be broached promptly after diagnosis of testicular cancer because they cause dissatisfaction with care and grief if fertility problems occur afterwards.Men with testicular cancer (TC) risk impaired fertility. Fertility is a major concern for TC patients due to diagnosis in almost always reproductive ages and high overall survival. This study assessed counselling in regards to the risk of impaired fertility and sperm cryopreservation. A cross-sectional survey was performed on 566 TC patients diagnosed between 1995-2015. Of the 566 survivors, 201 questionnaires were completed (35.5%). Eighty-eight percent was informed about possible impaired fertility, 9.5% was not informed. The majority (47.3%) preferred the urologist to provide information. Collecting sperm was troublesome but successful for 25.6%, 4.8% did not succeed in collecting sperm. The reasons were high pressure due to disease, pain after surgery and uncomfortable setting. Due to impaired fertility, 19% of the respondents reported grief and 9.3% stated as being less satisfied in life. Sperm cryopreservation was performed by 41.3% (n = 83). One third (n = 63, 31.3%) had children after treatment, of which 11.1% made use of preserved sperm (n = 7). The results of this survey indicate the importance of timely discussion of fertility issues with TC patients. While being discussed with most men, dissatisfaction and grief may occur as a result of impaired fertility and a lack of counselling. Overall, 6.5% made use of cryopreserved sperm (n = 13). Men prefer their urologist providing counselling on fertility.Development and application of statistical models for medical scientific researc

Efficacy and safety of a contraceptive vaginal ring (NuvaRing) compared with a combined oral contraceptive: a 1-year randomized trial

Abstract This open-label, randomized, Phase III study compared the efficacy and tolerability of and compliance with NuvaRing, a combined contraceptive vaginal ring releasing 15 Ag of ethinylestradiol (EE) and 120 Ag of etonogestrel daily, with those of and with a combined oral contraceptive (COC) containing 150 Ag of levonorgestrel (LNG) and 30 Ag of EE. Subjects received NuvaRing or a COC for 13 cycles (3 weeks of ring/pill treatment followed by a 1-week ring-/pill-free period). A total of 1030 subjects (NuvaRing, n = 512; COC, n = 518) was randomized and started treatment (intent-to-treat [ITT] population). The percentage of women in the ITT population who completed the trial was 70.9% for the NuvaRing group and 71.2% for the COC group. Five in-treatment pregnancies occurred in each group, giving Pearl indices of 1.23 for NuvaRing and 1.19 for the COC. Compliance with both treatments was excellent and both were well tolerated. In conclusion, NuvaRing has comparable efficacy and tolerability with a COC containing 150 Ag of LNG and 30 Ag of EE and does not require daily dosing.

Management of high-risk corneal grafts

MACMILLAN BUILDING,4 CRINAN ST, LONDON, ENGLAND, N1 9X

PENDAMPINGAN PSIKOLOGI KESEHATAN KERJA POS UPAYA KESEHATAN KERJA (UKK) NELAYAN TRADISIONAL TANJUNG PENI CITANGKIL CILEGON

Pendampingan ini dilakukan untuk memenuhi kebutuhan subyek dampingan, yang muncul karena ada masalah dan tantangan yang dihadapi para pekerja sektor informal pada saat ini, serta tuntutan peningkatan kualitas dan produktivitas kerja di masa mendatang. Salah satu strategi untuk menjawab masalah dan tantangan serta upaya memenuhi tuntutan tersebut adalah dengan memberikan pendampingan psikologi kesehatan kerja bagi para pekerja sektor informal, khususnya nelayan tradisional Di Tanjung Peni Citangkil, Cilegon. Oleh karenanya, dilakukan analisis “SWOT” sebagai pendekatan awal dalam membangun sebuah peta pemahaman dasar

When does War become Crime? Aspects of the Criminal Case against Eric O.

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