15 research outputs found
Editorial Comment on “Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study”
No full textDense Breast Ultrasound Screening After Digital Mammography Versus After Digital Breast Tomosynthesis
No full textFDG PET/CT of Infection: Should It Replace Labeled Leukocyte Scintigraphy of Inpatients?
No full textThe Current State of Nuclear Medicine and Nuclear Radiology: Workforce Trends, Training Pathways, and Training Program Websites
No full textReadability of Online Patient Educational Materials Related to Breast Lesions Requiring Surgery
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Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
No full textMurine invariant natural killer T (iNKT) cells provide cognate and non-cognate help for lipid and protein-specific B cells, respectively. However, the long term B cell outcome following cognate iNKT help is currently unknown. We show that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal center formation, affinity maturation and a robust primary IgG antibody response that was uniquely dependent on iNKT-derived interleukin 21 (IL-21). However, cognate iNKT cell help did not generate an enhanced humoral memory response. Thus, iNKT cell cognate help for lipid-specific B cells induces a unique signature which is a hybrid of classic T-dependent (TD) and T-independent type 2 (TI-2) B cell responses
Role of Environmental and Antibiotic Stress on Staphylococcus epidermidis Biofilm Microstructure
No full textInvariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner
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