899 research outputs found
The AMS-02 RICH Imager Prototype - In-Beam Tests with 20 GeV/c per Nucleon Ions -
A prototype of the AMS Cherenkov imager (RICH) has been tested at CERN by
means of a low intensity 20 GeV/c per nucleon ion beam obtained by
fragmentation of a primary beam of Pb ions. Data have been collected with a
single beam setting, over the range of nuclear charges 2<Z<~45 in various beam
conditions and using different radiators. The charge Z and velocity beta
resolutions have been measured.Comment: 4 pages, contribution to the ICRC 200
The Ring Imaging Cherenkov detector (RICH) of the AMS experiment
The Alpha Magnetic Spectrometer (AMS) experiment to be installed on the
International Space Station (ISS) will be equipped with a proximity focusing
Ring Imaging Cherenkov (RICH) detector for measuring the electric charge and
velocity of the charged cosmic particles. A RICH prototype consisting of 96
photomultiplier units, including a piece of the conical reflector, was built
and its performance evaluated with ion beam data. Preliminary results of the
in-beam tests performed with ion fragments resulting from collisions of a 158
GeV/c/nuc primary beam of Indium ions (CERN SPS) on a Pb target are reported.
The collected data included tests to the final front-end electronics and to
different aerogel radiators. Cherenkov rings for a large range of charged
nuclei and with reflected photons were observed. The data analysis confirms the
design goals. Charge separation up to Fe and velocity resolution of the order
of 0.1% for singly charged particles are obtained.Comment: 29th International Conference on Cosmic Rays (Pune, India
The AMS-RICH velocity and charge reconstruction
The AMS detector, to be installed on the International Space Station,
includes a Ring Imaging Cerenkov detector with two different radiators, silica
aerogel (n=1.05) and sodium fluoride (n=1.334). This detector is designed to
provide very precise measurements of velocity and electric charge in a wide
range of cosmic nuclei energies and atomic numbers. The detector geometry, in
particular the presence of a reflector for acceptance purposes, leads to
complex Cerenkov patterns detected in a pixelized photomultiplier matrix. The
results of different reconstruction methods applied to test beam data as well
as to simulated samples are presented. To ensure nominal performances
throughout the flight, several detector parameters have to be carefully
monitored. The algorithms developed to fulfill these requirements are
presented. The velocity and charge measurements provided by the RICH detector
endow the AMS spectrometer with precise particle identification capabilities in
a wide energy range. The expected performances on light isotope separation are
discussed.Comment: Contribution to the ICRC07, Merida, Mexico (2007); Presenter: F.
Bara
The RICH detector of the AMS-02 experiment: status and physics prospects
The Alpha Magnetic Spectrometer (AMS), whose final version AMS-02 is to be
installed on the International Space Station (ISS) for at least 3 years, is a
detector designed to measure charged cosmic ray spectra with energies up to the
TeV region and with high energy photon detection capability up to a few hundred
GeV. It is equipped with several subsystems, one of which is a proximity
focusing RICH detector with a dual radiator (aerogel+NaF) that provides
reliable measurements for particle velocity and charge. The assembly and
testing of the AMS RICH is currently being finished and the full AMS detector
is expected to be ready by the end of 2008. The RICH detector of AMS-02 is
presented. Physics prospects are briefly discussed.Comment: 5 pages. Contribution to the 10th ICATPP Conference on Astroparticle,
Particle, Space Physics, Detectors and Medical Physics Applications (Como
2007). Presenter: Rui Pereir
The Sensitivity of HAWC to High-Mass Dark Matter Annihilations
The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view
detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in
central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC
will observe gamma rays and cosmic rays with an array of water Cherenkov
detectors. The full HAWC array is scheduled to be operational in Spring 2015.
In this paper, we study the HAWC sensitivity to the gamma-ray signatures of
high-mass (multi- TeV) dark matter annihilation. The HAWC observatory will be
sensitive to diverse searches for dark matter annihilation, including
annihilation from extended dark matter sources, the diffuse gamma-ray emission
from dark matter annihilation, and gamma-ray emission from non-luminous dark
matter subhalos. Here we consider the HAWC sensitivity to a subset of these
sources, including dwarf galaxies, the M31 galaxy, the Virgo cluster, and the
Galactic center. We simulate the HAWC response to gamma rays from these sources
in several well-motivated dark matter annihilation channels. If no gamma-ray
excess is observed, we show the limits HAWC can place on the dark matter
cross-section from these sources. In particular, in the case of dark matter
annihilation into gauge bosons, HAWC will be able to detect a narrow range of
dark matter masses to cross-sections below thermal. HAWC should also be
sensitive to non-thermal cross-sections for masses up to nearly 1000 TeV. The
constraints placed by HAWC on the dark matter cross-section from known sources
should be competitive with current limits in the mass range where HAWC has
similar sensitivity. HAWC can additionally explore higher dark matter masses
than are currently constrained.Comment: 15 pages, 4 figures, version to be published in PR
Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence
<p>Abstract</p> <p>Background</p> <p>Chemotherapeutic drugs like Adriamycin (ADR) induces apoptosis or senescence in cancer cells but these cells often develop resistance and generate responses of short duration or complete failure. The methylxantine drug Pentoxifylline (PTX) used routinely in the clinics setting for circulatory diseases has been recently described to have antitumor properties. We evaluated whether pretreatment with PTX modifies apoptosis and senescence induced by ADR in cervix cancer cells.</p> <p>Methods</p> <p>HeLa (HPV 18+), SiHa (HPV 16+) cervix cancer cells and non-tumorigenic immortalized HaCaT cells (control) were treated with PTX, ADR or PTX + ADR. The cellular toxicity of PTX and survival fraction were determinated by WST-1 and clonogenic assay respectively. Apoptosis, caspase activation and ADR efflux rate were measured by flow cytometry, senescence by microscopy. IκBα and DNA fragmentation were determinated by ELISA. Proapoptotic, antiapoptotic and senescence genes, as well as HPV-E6/E7 mRNA expression, were detected by time real RT-PCR. p53 protein levels were assayed by Western blot.</p> <p>Results</p> <p>PTX is toxic (WST-1), affects survival (clonogenic assay) and induces apoptosis in cervix cancer cells. Additionally, the combination of this drug with ADR diminished the survival fraction and significantly increased apoptosis of HeLa and SiHa cervix cancer cells. Treatments were less effective in HaCaT cells. We found caspase participation in the induction of apoptosis by PTX, ADR or its combination. Surprisingly, in spite of the antitumor activity displayed by PTX, our results indicate that methylxantine, <it>per se </it>does not induce senescence; however it inhibits senescence induced by ADR and at the same time increases apoptosis. PTX elevates IκBα levels. Such sensitization is achieved through the up-regulation of proapoptotic factors such as <it>caspase </it>and <it>bcl </it>family gene expression. PTX and PTX + ADR also decrease E6 and E7 expression in SiHa cells, but not in HeLa cells. p53 was detected only in SiHa cells treated with ADR.</p> <p>Conclusion</p> <p>PTX is a good inducer of apoptosis but does not induce senescence. Furthermore, PTX reduced the ADR-induced senescence and increased apoptosis in cervix cancer cells.</p
VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory
VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l.
in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design,
construction techniques and data acquisition system of the HAWC observatory.
HAWC is an air-shower array currently under construction at the same site of
VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water
Cherenkov detectors and two different data acquisition systems. It was in
operation between October 2011 and May 2012 with an average live time of 30%.
Besides the scientific verification purposes, the eight months of data were
used to obtain the results presented in this paper: the detector response to
the Forbush decrease of March 2012, and the analysis of possible emission, at
energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages,
10 figures). Corresponding authors: A.Marinelli and D.Zaboro
The 2HWC HAWC Observatory Gamma Ray Catalog
We present the first catalog of TeV gamma-ray sources realized with the
recently completed High Altitude Water Cherenkov Observatory (HAWC). It is the
most sensitive wide field-of-view TeV telescope currently in operation, with a
1-year survey sensitivity of ~5-10% of the flux of the Crab Nebula. With an
instantaneous field of view >1.5 sr and >90% duty cycle, it continuously
surveys and monitors the sky for gamma ray energies between hundreds GeV and
tens of TeV.
HAWC is located in Mexico at a latitude of 19 degree North and was completed
in March 2015. Here, we present the 2HWC catalog, which is the result of the
first source search realized with the complete HAWC detector. Realized with 507
days of data and represents the most sensitive TeV survey to date for such a
large fraction of the sky. A total of 39 sources were detected, with an
expected contamination of 0.5 due to background fluctuation. Out of these
sources, 16 are more than one degree away from any previously reported TeV
source. The source list, including the position measurement, spectrum
measurement, and uncertainties, is reported. Seven of the detected sources may
be associated with pulsar wind nebulae, two with supernova remnants, two with
blazars, and the remaining 23 have no firm identification yet.Comment: Submitted 2017/02/09 to the Astrophysical Journa
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