Estrategias lúdicas para fortalecer la motricidad gruesa en los niños de preescolar de la institución educativa bajo grande – sahagún.

El objeto de estudio de la Pedagogía es la educación. Así, también es posible encontrar la palabra formación como objeto de estudio de la Pedagogía, siendo educación y formación vocablos sinónimos en tal contexto. En ese orden de ideas, la investigación educativa pretende encontrar las razones por las cuales se dan o presentan algunos problemas en el desarrollo motriz de los niños y buscar la forma como corregirlos a través de los procesos de aprendizaje, por ello este proyecto de investigación pretende determinar actividades que logren fortalecer la motricidad gruesa en los niños del grado preescolar de la INSTITUCIÓN EDUCATIVA BAJO GRANDE- SAHAGÚN, sede principal

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality