Good and bad of the COVID-19 pandemic

This entry describes the way the COVID-19 pandemic has impacted the author\u27s life both negatively and positively.https://dc.ewu.edu/covid/1035/thumbnail.jp

Entropy-expansiveness for partially hyperbolic diffeomorphisms

We show that diffeomorphisms with a dominated splitting of the form $E^s\oplus E^c\oplus E^u$, where $E^c$ is a nonhyperbolic central bundle that splits in a dominated way into 1-dimensional subbundles, are entropy-expansive. In particular, they have a principal symbolic extension and equilibrium states.Comment: 15 pages, 1 figur

Prostaglandin E2-EP1 and EP2 receptor signaling promotes apical junctional complex disassembly of Caco-2 human colorectal cancer cells

<p>Abstract</p> <p>Background</p> <p>The apical junctional complex (AJC) is a dynamic structure responsible to maintain epithelial cell-cell adhesions and it plays important functions such as, polarity, mechanical integrity, and cell signaling. Alteration of this complex during pathological events leads to an impaired epithelial barrier by perturbation of the cell-cell adhesion system. Although clinical and experimental data indicate that prostaglandin E₂(PGE₂) plays a critical function in promoting cell motility and cancer progression, little is known concerning its role in AJC disassembly, an event that takes place at the beginning of colorectal tumorigenesis. Using Caco-2 cells, a cell line derived from human colorectal cancer, we investigated the effects of prostaglandin E₂(PGE₂) treatment on AJC assembly and function.</p> <p>Results</p> <p>Exposition of Caco-2 cells to PGE₂promoted differential alteration of AJC protein distribution, as evidenced by immunofluorescence and immunoblotting analysis and impairs the barrier function, as seen by a decrease in the transepithelial electric resistance and an increase in the permeability to ruthenium red marker. We demonstrated the involvement of EP1 and EP2 prostaglandin E₂receptor subtypes in the modulation of the AJC disassembly caused by prostanoid. Furthermore, pharmacological inhibition of protein kinase-C, but not PKA and p38MAPK significantly prevented the PGE₂effects on the AJC disassembly.</p> <p>Conclusion</p> <p>Our findings strongly suggest a central role of Prostaglandin E2-EP1 and EP2 receptor signaling to mediate AJC disassembly through a mechanism that involves PKC and claudin-1 as important target for the TJ-related effects in human colorectal cancer cells (Caco-2).</p

Video Endoscopy for Laser Photoresection in Tracheobronchial Pathology: Some Considerations After 9 Years Experience With 2105 Treatments

Between 1984 and 1993 we performed 2105 laser treatments in 1210 patients: 52% of treatments were done for malignant pathology, 45% for benign tracheal stenoses and 3% were in a miscellaneous group. The procedure was carried out with a rigid bronchoscope under general anaesthesia. In patients with malignant tumors, it is a good palliative treatment—safe, well tolerated and with immediate results; it can be repeated as many times as needed with and is well accepted by the patient. In patients without tumors, this method avoids emergency tracheotomies. The long term results are now under evaluation

Admittance Controller Complemented with Real-time Singularity Avoidance for Rehabilitation Parallel Robots

Rehabilitation tasks demand robust and accurate trajectory-tracking performance, mainly achieved with parallel robots. In this field, limiting the value of the force exerted on the patient is crucial, especially when an injured limb is involved. In human-robot interaction studies, the admittance controller modifies the location of the robot according to the user efforts driving the end-effector to an arbitrary location within the workspace. However, a parallel robot has singularities within the workspace, making implementing a conventional admittance controller unsafe. Thus, this study proposes an admittance controller that overcomes the limitations of singular configurations by using a real-time singularity avoidance algorithm. The singularity avoidance algorithm modifies the original trajectory based on the actual location of the parallel robot. The complemented admittance controller is applied to a 4 degrees of freedom parallel robot for knee rehabilitation. In this case, the actual location is measured by a 3D tracking system because the location calculated by the forward kinematics is inaccurate in the vicinity of a singularity. The experimental results verify the effectiveness of the proposed admittance controller for safe knee rehabilitation exercise

Testing a pyroclimatic hypothesis on the Mexico-United States border

The “pyroclimatic hypothesis” proposed by F. Biondi and colleagues provides a basis for testable expectations about climatic and other controls of fire regimes. This hypothesis asserts an a priori relationship between the occurrence of widespread fire and values of a relevant climatic index. Such a hypothesis provides the basis for predicting spatial and temporal patterns of fire occurrence based on climatic control. Forests near the Mexico–United States border offer a place to test the relative influence of climatic and other controls in mountain ranges that are ecologically similar and subject to broadly similar top-down climatic influence, but with differing cultural influences. We tested the pyroclimatic hypothesis by comparing fire history information from the Mesa de las Guacamayas, a mountain range in northwestern Chihuahua, with previously published fire data from the Chiricahua Mountains, in southeastern Arizona, approximately 150 km away. We developed a priori hypothetical models of fire occurrence and compared their performance to empirical climate-based models. Fires were frequent at all Mesa de las Guacamayas study sites through the mid-20th century and continued uninterrupted to the present at one site, in contrast to nearly complete fire exclusion after 1892 at sites in the Chiricahua Mountains. The empirical regression models explained a higher proportion of the variability in fire regime associated with climate than did the a priori models. Actual climate–fire relationships diverged in each country after 1892. The a priori models predicted continuing fires at the same rate per century as prior to 1892; fires did in fact continue in Mexico, albeit with some alteration of fire regimes, but ceased in the United States, most likely due to changes in land use. The cross-border comparison confirms that a frequent-fire regime could cease without a climatic cause, supporting previous arguments that bottom-up factors such as livestock grazing can rapidly and drastically alter surface fire regimes. Understanding the historical patterns of climate controls on fire could inform the use of historical data as ecological reference conditions and for future sustainability

Millimagnitude Photometry for Transiting Extrasolar Planetary Candidates IV: The Puzzle of the Extremely Red OGLE-TR-82 Primary Solved

We present precise new V, I, and K-band photometry for the planetary transit candidate star OGLE-TR-82. Good seeing V-band images acquired with VIMOS instrument at ESO VLT allowed us to measure V=20.6+-0.03 mag star in spite of the presence of a brighter neighbour about 1" away. This faint magnitude answers the question why it has not been possible to measure radial velocities for this object. One transit of this star has been observed with GMOS-S instrument of GEMINI-South telescope in i and g-bands. The measurement of the transit allows us to verify that this is not a false positive, to confirm the transit amplitude measured by OGLE, and to improve the ephemeris. The transit is well defined in i-band light curve, with a depth of A_i=0.034 mag. It is however, less well defined, but deeper (A_g=0.1 mag) in the g-band, in which the star is significantly fainter. The near-infrared photometry obtained with SofI array at the ESO-NTT yields K=12.2+-0.1 and V-K=8.4+-0.1, so red that it is unlike any other transit candidate studied before. Due to the extreme nature of this object, we have not yet been able to measure velocities for this star, but based on the new data we consider two different possible configurations:(1) a nearby M7V star, or (2) a blend with a very reddened distant red giant. The nearby M7V dwarf hypothesis would give a radius for the companion of R_p=0.3+-0.1 R_J, i.e. the size of Neptune. Quantitative analysis of near-IR spectroscopy finally shows that OGLE-TR-82 is a distant, reddened metal poor early K giant. This result is confirmed by direct comparison with stellar templates that gives the best match for a K3III star. Therefore, we discard the planetary nature of the companion. Based on all the new data, we conclude that this system is a main-sequence binary blended with a background red giant.Comment: 26 pages, 9 figures, ApJ accepte

Node assembly for waste level measurement: embrace the smart city

Municipal Solid Waste Management Systems (MSWMS) worldwide are currently facing pressure due to the rapid growth of the population in cities. One of the biggest challenges in this system is the inefficient expenditure of time and fuel in waste collection. In this regard, cities/- municipalities in charge of MSWMS could take advantage of information and communication technologies to improve the overall quality of their infrastructure. One particular strategy that has been explored and is showing interesting results is using a Wireless Sensors Network (WSN) to monitor waste levels in real-time and help decision-making regarding the need for collection. The WSN is equipped with sensing devices that should be carefully chosen considering the real scenario in which they will work. Therefore, in this work, three sets of sensors were studied to evaluate which is the best to be used in the future WSN assembled in Bragança, Portugal. Sets tested were HC-SR04 (S1), HC-SR04 + DHT11 (S2), and US-100 (S3). Tests considered for this work were air temperature and several distances. In the first, the performance of each set to measure a fixed target (metal and plastic box) was evaluated under different temperatures (1.7 - 37 ℃). From these results, two best sets were further used to assess distance measurement at a fixed temperature. This test revealed low absolute errors measuring the distances of interest in this work, ranging from 0.18% to 1.27%.This work has been supported by FCT - Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/05757/2020, UIDB/00690/2020, LA/P/0045/2020, UIDB/50020/2020, and UIDP/50020/2020. Adriano Silva was supported by FCT-MIT Portugal PhD grant SFRH/BD/151346/2021, and Thadeu Brito was supported by FCT PhD grant SFRH/BD/08598 /2020. Jose L. Diaz de Tuesta acknowledges the finantial support through the program of Atraccion de Talento of Atraccion al Talento of the Comunidad de Madrid (Spain) for the individual research grant 2020-T2/AMB-19836.info:eu-repo/semantics/acceptedVersio